Osteosarcoma of the femur in early adult: a case report


  • Reem H. Khamis Specialist Family Medicine Physician, Al Thummama Health Centre, Primary Health Care Corporation, Doha, Qatar
  • Thafar S. Al Safar Specialist Family Medicine Physician, Al Thummama Health Centre, Primary Health Care Corporation, Doha, Qatar
  • Nesrin K. Sulyman Consultant Internal Medicine Physician, Al Thummama Health Centre, Primary Health Care Corporation, Doha, Qatar




Biopsy, Non ossifying fibroma, Osteosarcoma, Radiography, Tumor


Osteosarcomas are primary malignant tumors of bone that are characterized by the production of osteoid or immature bone by the malignant cells. Osteosarcomas are uncommon tumors. Most articles reveal difficulty in diagnosing osteosarcoma in early stage due to its resemblance to benign lesion. That’s why we prefer to do case report for documentation. Diagnosis of the tumor is important especially in early stages for improving prognosis. This case report is of a 21 years old female who presented at Primary Health Care Centre with swelling above right knee post trauma a month ago. Previously she was diagnosed as Non ossifying fibroma (which is a benign lesion and uncommon to change to malignant lesion) at the same site in 2017.



Mirabello L, Troisi RJ, Savage SA. International osteosarcoma incidence patterns in children and adolescents, middle ages and elderly persons. Inter J Cancer. 2009 Jul 1;125(1):229-34.

Harvei S, Solheim Ø. The prognosis in osteosarcoma: Norwegian national data. Cancer. 1981 Oct 15;48(8):1719-23.

Sutow WW, Sullivan MP, Fernbach DJ, Cangir A, George SL. Adjuvant chemotherapy in primary treatment of osteogenic sarcoma. A Southwest Oncology Group study. Cancer. 1975 Nov;36(5):1598-602.

Eilber F, Giuliano A, Eckardt J, Patterson K, Moseley S, Goodnight J. Adjuvant chemotherapy for osteosarcoma: a randomized prospective trial. J Clin Oncol. 1987 Jan;5(1):21-6.

Cho WH, Song WS, Jeon DG, Kong CB, Kim MS, Lee JA, et al. Differential presentations, clinical courses, and survivals of osteosarcomas of the proximal humerus over other extremity locations. Annal Surg Oncol. 2010 Mar 1;17(3):702-8.

Kaste SC, Liu T, Billups CA, Daw NC, Pratt CB, Meyer WH. Tumor size as a predictor of outcome in pediatric non‐metastatic osteosarcoma of the extremity. Pediatr Blood Cancer. 2004 Dec;43(7):723-8.

Mirabello L, Troisi RJ, Savage SA. Osteosarcoma incidence and survival rates from 1973 to 2004: data from the Surveillance, Epidemiology, and End Results Program. Cancer: Interdisciplinary Intern J Am Cancer Soci. 2009 Apr 1;115(7):1531-43.

Yildiz C, Erler K, Atesalp AS, Basbozkurt M. Benign bone tumors in children. Curr Opinion Pediatr. 2003 Feb 1;15(1):58-67.

Kesselring FO, Penn W. Radiological aspects of 'classic' primary osteosarcoma: value of some radiological investigations: A review. Diagn Imaging. 1982;51:78.

Panicek DM, Gatsonis C, Rosenthal DI, Seeger LL, Huvos AG, Moore SG, et al. CT and MR imaging in the local staging of primary malignant musculoskeletal neoplasms: Report of the Radiology Diagnostic Oncology Group. Radiology. 1997 Jan;202(1):237-46.

Xiong Y, Lang Y, Yu Z, Liu H, Fang X, Tu C, et al. The effects of surgical treatment with chondroblastoma in children and adolescents in open epiphyseal plate of long bones. World J Surg Oncol. 2018 Dec 1;16(1):14.

Steiner GC. Fibrous cortical defect and nonossifying fibroma of bone. A study of the ultrastructure. Archiv Pathol. 1974 Apr;97(4):205.

Biermann JS. Common benign lesions of bone in children and adolescents. J Pediatr Orthopaed. 2002 Mar 1;22(2):268-73.

Nielsen GP, Kyriakos M. Non-ossifying fibroma/benign fibrous histiocytoma of bone. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. IARC Press: Lyon. 2013:302-4.

Copley L, Dormans JP. Benign pediatric bone tumors: Evaluation and treatment. Pediatr Clin. 1996 Aug 1;43(4):949-66.




How to Cite

Khamis, R. H., Al Safar, T. S., & Sulyman, N. K. (2020). Osteosarcoma of the femur in early adult: a case report. International Journal of Research in Medical Sciences, 8(4), 1589–1592. https://doi.org/10.18203/2320-6012.ijrms20201367



Case Reports