Effect of dexamethasone with granisetron or ondansetron for prevention of post-operative nausea vomiting in patients undergoing laparoscopic gynaecological surgery

Authors

  • Shailendra Kumar Sharma Department of Anaesthesiology and Critical Care, Military Hospital, Bhopal, Madhya Pradesh, India
  • Shalendra Singh Department of Anaesthesiology and Critical Care, Armed Forces Medical College Pune, Maharashtra, India
  • Debashish Paul Department of Anaesthesiology and Critical Care, Armed Forces Medical College Pune, Maharashtra, India
  • Nihar Ameta Department of Anaesthesiology and Critical Care, 160 Military Hospital, Masimpur, Assam, India
  • Priya Taank Department of Ophthalmology, Command Hospital (Southern Command) Pune, Maharashtra, India
  • Tina Singh Department of Obstetrics and Gynaecology, INHS Asvini, Mumbai, Maharashtra, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20201319

Keywords:

General anaesthesia, Laproscopic surgery, Post-operative nausea vomiting

Abstract

Background: Post-operative nausea and vomiting (PONV) is generally self-limiting, associated with high level of patient dissatisfaction and may delay hospital discharge. The anaesthetist is usually blamed, despite evidence that PONV results from a variety of factors and variety of antiemetic drug available in market. With this issue we aim to compare the effectiveness of dexamethasone with granisetron or ondansetron in patients undergoing laparoscopic gynaecological surgery.

Methods: 120 patients were registered in this prospective, randomized double blind study. Group I (n=60) received ondansetron 4 mg intravenously (IV)+dexamethasone 8mg I/V or II (n=60) received granisetron 1 mg IV+dexamethasone 8 mg I/V prior to anaesthesia. Post-operative data of PONV was recorded at pre-defined intervals.

Results: The majority of the patients were of the age group 20-25 years (55.83%). The mean score of Group I subjects was 0.30±0.72 and that of Group II was 0.20±0.57 (p=0.43).  There are 3.33% of patients in group-I having vomiting episodes, and 1.67% of patients in group-II having vomiting episodes, none of the patients developed 2nd episodes of vomiting in either group. Thus it appears that dexamethasone in combination with ondansetron and granisetron is effective in decreasing the number of episodes of PONV. The occurrence of sickness episodes within 24 hours of surgery revealed no significant different in both groups. Haemodynamic variables showed no significant difference recorded in postoperative care unit between the study groups. The most common complaint was headache 16.67% in both groups.  

Conclusions: Dexamethasone 8 mg with either granisetron 1 mg or ondansetron 4 mg showed no significant difference in antiemetic efficacy with minimal side effects and excellent patient satisfaction.

References

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Published

2020-03-26

How to Cite

Sharma, S. K., Singh, S., Paul, D., Ameta, N., Taank, P., & Singh, T. (2020). Effect of dexamethasone with granisetron or ondansetron for prevention of post-operative nausea vomiting in patients undergoing laparoscopic gynaecological surgery. International Journal of Research in Medical Sciences, 8(4), 1331–1335. https://doi.org/10.18203/2320-6012.ijrms20201319

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Original Research Articles