Published: 2020-02-26

The study of correlation between thyroid function and blood pressure in hypertensive patients attending out patient department in tertiary care centre

Aparna Patange, Harsh Shah, Harshil Vora


Background: Hypertension may be the initial clinical presentation for at least 15 endocrine disorders, including overt and subclinical hyperthyroidism and hypothyroidism. The correction of thyroid dysfunction may normalize Blood Pressure (BP) in most cases, therefore checking thyroid function is essential during the workup for hypertension. The present study was conducted to find out the association between hypertension and thyroid dysfunction.

Methods: It was a retrospective, observational study conducted among patients having hypertension visiting the outpatient department of Medicine in KIMS Karad, during the period of 2 months.

Results: The mean values of various thyroid function parameters among hypertensive cases was assessed in the current study, Authors found that the mean Serum T3 level was 93.5917±32.82, Mean Serum T4 level was 6.72±1.64 and the mean Serum TSH level was 2.52±2.71. Among all the cases about 52% cases had deranged thyroid function reports.

Conclusions: The results of this study suggest an association between subclinical hypothyroidism and increased blood pressure levels.


Hyperthyroidism, Hypertension, Subclinical hypothyroidism, Thyroid dysfunction, Thyroid Stimulating Hormone

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Kearney P, Whelton M, Reynolds K, Muntner P, Whelton P, He J. Global burden of hypertension: analysis of worldwide data. Lancet. 2005;(9455):217-23.

Forouzanfar MH, Alexander L, Bachman VF, Biryukov S, Brauer M, Casey D, et al. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2015;386:2287-323.

Charles L, Triscott J, Dobbs B. Secondary hypertension: Discovering the underlying cause. Am Family Phys. 2017 Oct 1;96(7):453-61.

Young Jr WF, Calhoun DA, Lenders JW, Stowasser M, Textor SC. Screening for endocrine hypertension: an endocrine society scientific statement. Endo Rev. 2017 Apr 1;38(2):103-22.

Chaker L, Bianco AC, Jonklaas J, Peeters RP. Hypothyroidism. Lancet. 2017;390(10101):1550-62.

Hoogendoorn EH, Hermus AR, De VegT F, Ross HA, Verbeek AL, Kiemeney LA, et al. Thyroid function and prevalence of anti-thyroperoxidase antibodies in a population with borderline sufficient iodine intake: influences of age and sex. Clin Chem. 2006 Jan 1;52(1):104-11.

Tewari N. Prevalence of hypothyroidism in adults: An epidemiological study in eight cities of India. Ind J Endocrinol Metab. 2014 Jan;18(1):116.

Talwalkar P, Deshmukh V, Bhole M. Prevalence of hypothyroidism in patients with type 2 diabetes mellitus and hypertension in India: a cross-sectional observational study. Diabetes, Metab Synd Obes: Targ Therapy. 2019;12:369.

Bassey IE, Gali RM, Essien OE, Udoh AE, Emordi B, Akpan UO. Thyroid function in hypertensives in South-South Nigeria. Inter J Res Med Sci. 2016 Jan;4(1):190.

Luboshitzky R, Aviv A, Herer P, Lavie L. Risk factors for cardiovascular disease in women with subclinical hypothyroidism. Thyroid. 2002 May 1;12(5):421-5.

Åsvold BO, Bjøro T, Nilsen TI, Vatten LJ. Association between blood pressure and serum thyroid-stimulating hormone concentration within the reference range: a population-based study. J Clin Endocrinol Metab. 2007 Mar 1;92(3):841-5.