Study of histomorphological spectrum of lesions in nephrectomy specimen in a tertiary care hospital in South Gujarat


  • Himani Bajaj Department of Pathology, Government Medical College, Surat, Gujarat, India
  • Rasik Hathila Department of Pathology, Government Medical College, Surat, Gujarat, India



Chronic pyelonephritis, Nephrectomy, Renal cell carcinoma


Background: Nephrectomy is a standard surgical procedure in urology indicated in patients with organ confined renal malignancies and irreversible kidney damage resulting from chronic infection, trauma, obstruction and congenital malformation. This study aims to study the histomorphological features of lesions in nephrectomy specimens in a tertiary care hospital, to analyse the neoplastic and non-neoplastic lesions of kidney according to age, gender and site and observe any variation from the conventional pattern.

Methods: The present study was conducted in department of pathology, Tertiary care hospital over a period of 5 years and 7 months (1 Jan 2013 to July 31, 2018). This included 4 years retrospective and 1 year 7 months prospective.  A total of 73 cases of were studied.

Results: Males constituted 65.73% and females constituted 35.27%  of all nephrectomy cases. Right kidney was more commonly affected. Highest percentage of patients belonged to 41-50 years age group. 45 cases were of non-neoplastic lesions and 28 cases were of neoplastic lesions. Among neoplastic lesions, one case was benign while remaining 27 cases were malignant. Chronic Pyelonephritis was the most common indication overall and also amongst non-neoplastic lesions with stone identified in 55% cases. Most common neoplastic lesion in nephrectomy specimen was Renal Cell carcinoma (71.4.1%) followed by Wilms tumour (14%).

Conclusions: This study gives a fair insight of the current state of incidence of neoplastic and non-neoplastic lesions of kidney requiring surgical intervention.


Alpers C, Chang A. The Kidney. In: Kumar V, Abbas A, Aster J. Robbins and Cotran’s Pathological Basis of Disease. 9th ed. Elsevier Health Sciences; 2014:897-957.

Kathirvelu S, Rajvaithy A, Venkatraman K. Histopathological spectrum of Nephrectomy specimen in a tertiary care centre: with an emphasis on Chronic Pyelonephritis. Ann Pathol Lab Medi. 2017 Oct 30;4(5):A573-8.

O’Rourke DM, Allen DC. Kidney, Renal Pelvis, and Ureter. In: Allen D, Cameron R, eds. Histopathology specimens: clinical, pathological and laboratory aspects. 1st ed. Berlin/ Heidelberg: Springer; 2004: 285-299.

Kambham N. Kidney: Non-Neoplastic Diseases. In: Goldblum JR, Lamps LW, McKenney JK, Myers JL, Juan R, Ackerman, eds. Rosai and Ackerman’s surgical pathology. 11th ed. Vol. 1, Elsevier Health Sciences. Elsevier; 2018:936-1013.

Nádasdy T, Satoskar A, Molnar-Nádasdy G. Adult Renal Diseases. In: Mills SE, Greenson JK, Hornick JL, Longacre TA, Reuter VE, eds. Sternberg’s diagnostic surgical pathology. 6th ed. Wolters Kluwer; 2015:5223-5612

Moch H, Cubilla AL, Humphrey PA, Reuter VE, Ulbright TM. WHO Classification of Tumours of the Urinary System and Male Genital Organs. 4th ed. Lyon, International Agency for Research on Cancer (IARC); 2016:11-76.

Muscat JE, Hoffmann D, Wynder EL. The epidemiology of renal cell carcinoma. A second look. Cancer. 1995 May 15;75(10):2552-7.

Datta B, Moitra T, Chaudhury DN, Halder B. Analysis of 88 nephrectomies in a rural tertiary care center of India. Saudi J Kidney Dis Transplantat. 2012 Mar 1;23(2):409.

El Fadil MA, Memon SR, Ibrahim AL, Al Gizawi A, Ghali AM. Nephrectomy in adults: Asir Hospital experience. Saudi J Kidney Dis Transplantat. 1997 Oct 1;8(4):423.

Latif F, Mubarak M, Kazi JI. Histopathological characteristics of adult renal tumours: a preliminary report. J Pak Medi Assoc. 2011;61(3):224-8.

Mehra M, Pramod, Gupta N, Sharma L. Histopathological Patterns of Renal Tumours Seen in Nephrectomy Specimens : A Three Year Experience at a Tertiary Care Hospital in Western Part of Rajasthan. Int J Medi Res Profess. 2016;2(2):221-4.

Shaila, Nityananda BS, Tamil Arasi. Spectrum of Lesions in Nephrectomy Specimens in Tertiary Care Hospital. J Evolut Medi Dental Scie. 2015;4(73):12714-26.

Vinay KS, Sujatha S. Histopathological Spectrum of Nephrectomy Specimens: Single Center Experience. Biomedi J Scie Technol Res. 2018;6(3):1-5

Suryawanshi KH, Damle RP, Dravid NV, Rawandale AP, Surana A. Histomorphological Analysis of Lesions In Nephrectomy Specimens: A 4 Years Study In A Rural Hospital In India- Our Experience. Ann Pathol Lab Med. 2017;4(3):A230-5.

Rafique M. Nephrectomy: Indications, complications and mortality in 154 consecutive patients. J Pak Medi Assoc. 2007;57(6):308-11.

Reddy KD, Gollapalli SL, Sujitha C, Sidagam S, Khan AM, Bommana A. A Clinico-Morphological Spectrum of Nephrectomy Specimens - An Experience from a Tertiary Care Hospital. Int J Sci Healthc Res. 2016;6(11):67-72.

Amin AN, Pai P, Upadhyaya K. A Histopathological Spectrum Of Nephrectomy Specimens In A Tertiary Hospital. Int J Biolog Medi Res. 2015;6(2):5173-8.

Kumar M, Meghana P, Vasudev V, Bharathi M. Histopathological Spectrum of Nephrectomy Specimens. Ann Pathol Lab Medi. 2019;6(1):A49-53.

Kulkarni SP, Sonkawade D, Patro N, Kaur S, Sawadkar M. Spectrum of lesions in non-neoplastic nephrectomy specimens and their clinico-pathological correlation- a tertiary care hospital experience. Ind J Pathol Oncol. 2019;6(4):574-8.

Yasir M, Aiman A, Singh K. Histopathological spectrum of lesions in nephrectomy specimens: A five-year experience in a tertiary care hospital. J Sci Soc. 2013;40(3):148-54.

Meena S, Pathak V, Sukheeja D, Bhati R, Shahida R. Histomorphological Profile of Nephrectomy Specimen in a Tertiary Care Centre Of Rajasthan: A case Series of 100 specimen. Int J Curr Res.2017;9(2):47187-90.

Ghalayini IF. Pathological spectrum of nephrectomies in a general hospital. Asian J Surg. 2002;25(2):163-9.

Divyashree BN, Venkatesh K, Madhusudhan H, Hanumantha Raju B. Pathological Spectrum of Non -Neoplastic Diseases in the Nephrectomy Specimens. J Evid Based Med Healthc. 2014;1(15):1909-20.

Kumar A. A histopathological study of non-neoplastic lesions in nephrectomy specimens. Int J Med Heal Res. 2017;3(2):2454-9142

Sreedhar VV, Charan Paul M, Sirisha O, Shivaram P, Sudhir N. Pathological study of elective nephrectomies for a two year period. Int J Res Med Sci. 2015;3(6):1496-500

Maheshwari S, Sujata J. A retrospective analysis of renal lesions in nephrectomy specimen in a tertiary care hospital. Paripex Ind J Res. 2018;7(6):10-1.

Bashir N, Bashir Y, Shah P, Bhat N, Salim O, Samoon N, et al. Histopathological Study of Renal Tumors in Resected Nephrectomy Specimens -an Experience From Teritary Care Centre. Nat J Medi Res. 2015;5(1):25-9.

Barrantes JC, Muir KR, Toyn CE, Parkes SE, Cameron AH, Marsden HB, et al. Thirty‐year population‐based review of childhood renal tumours with an assessment of prognostic features including tumour DNA characteristics. Medi Pediatr Oncol. 1993;21(1):24-30.

Bjelke E. Malignant neoplasms of the kidney in children. Cancer. 1964;17:318-21.

Ezomike UO, Modekwe VI, Ekenze SO. Paediatric nephrectomy: Patterns, indications and outcome in a developing country. Malawi Med J. 2018 Jun 30;30(2):94.




How to Cite

Bajaj, H., & Hathila, R. (2020). Study of histomorphological spectrum of lesions in nephrectomy specimen in a tertiary care hospital in South Gujarat. International Journal of Research in Medical Sciences, 8(5), 1706–1712.



Original Research Articles