Frequency of early post operative complications of modified radical mastectomy within period of four weeks


  • Rekha Melwani Department of General Surgery, Al-Tibri Medical College, Isra University, Karachi, Pakistan
  • Sadaf Jabeen Malik Department of General Surgery, Al-Tibri Medical College, Isra University, Karachi, Pakistan
  • Sobohi Shakeel Department of Surgery, Sindh Public Government Hospital, Karachi, Pakistan
  • Shahid Zafar Department of Pathology, Liaquat College of Medicine and Dentistry, Karachi, Pakistan
  • Muhammad Yousif Khoso Department of Pathology, Al-Tibri Medical College, Isra University, Karachi, Pakistan
  • Syed Naqeeb Ali Department of Pathology, Al-Tibri Medical College, Isra University, Karachi, Pakistan



Fine needle aspiration cytology, Modified radical mastectomy, Outpatient department, Seroma


Background: Most of the complications are developed after modified radical mastectomy in breast cancer patients, hence to avoid and reduces the postoperative complications, this study is performed to identify the frequency of early post-operative complications of modified Radical Mastectomy within the period of four weeks.

Methods: Cross-sectional case series using non-probability convenient sampling technique was conducted in surgical unit I of Tertiary care hospital, for 1 year from 15 January 2018 to 14 January 2019. 89 patients FNAC proved breast cancer were included, patients that received neoadjuvant chemo or radiotherapy or with inflammatory breast cancer, metastasis and with co-morbid were excluded. After taking consent patients were operated by senior consultant. Follow up was taken daily 7th post-operative day and then followed in OPD on weekly basis fourth week and final outcome was noted. SPSS version 23 was used for data analysis. Quantitative data was reported as frequency in percentages.

Results: Total 31 patients developed complications during the study, accounts 34% of total patients. The most common complication was breast seroma in 12(13.48%) of cases with an increased risk in cases of age >50 yr, size of tumor >8 cm, weight >70 kg and increased number of lymph nodes [3 or above] palpable after wards hematoma in 6(6.74%), lymphedema in 5(5.62%), wound infection 4(4.49%) and shoulder dysfunction in 4(4.49%) patients, no patient was found scar hypertrophy.

Conclusions: Seroma formation, hematoma were found most common early complications after modified radical mastectomy, lymphedema, wound infection and shoulder dysfunction were observed in small number of patients.


Cifu G, Arem H. Adherence to lifestyle-related cancer prevention guidelines and breast cancer incidence and mortality. Ann Epidemiol. 2018 Nov 1;28(11):767-73.

Espie M, Lalloum M, Coussy F. Epidemiology and risk factors of breast cancer. Soins; La Rev De Refer Infirm. 2013 Jun;776:22-4.

Begum N. Breast Cancer in Pakistan: A Looming Epidemic. J Coll Physicians Surg Pak. 2018 Feb 1;28(2):87-8.

Zgajnar J. Clinical Presentation, Diagnosis and Staging of Breast Cancer. InBreast Cancer Management for Surgeons 2018:159-76.

Chen Z, Xu Y, Shu J, Xu N. Breast-conserving surgery versus modified radical mastectomy in treatment of early stage breast cancer: a retrospective study of 107 cases. J Cancer Res Therap. 2015 Aug 1;11(5):29.

Yan M, Abdi MA, Falkson C. Axillary Management in Breast Cancer Patients: a comprehensive review of the key trials. Clini Breast Cancer. 2018 Dec 1;18(6):1251-9.

Зикиряходжаев А, Zikiryahodjaev A, Ермощенкова М, Ermoshchenkova M, Каприн А, Kaprin AD, et al. Modern Trends in the Breast Cancer Conserving Surgery and Oncoplastic Breast Surgery. Medi Radiol Radiat Safet. 2018;63(6):51-8.

Faisal M, Abu-Elela ST, Mostafa W, Antar O. Efficacy of axillary exclusion on seroma formation after modified radical mastectomy. World J Surg Oncol. 2016 Dec;14(1):39.

Chandrakar N, Shinde RK. Study the early complications of modified radical mastectomy performed. Int Surg J. 2018 Dec 27;6(1):239-43.

DeSantis CE, Ma J, Goding Sauer A, Newman LA, Jemal A. Breast cancer statistics, 2017, racial disparity in mortality by state. CA: Cancer J Clini. 2017 Nov;67(6):439-48.

Guo F, Kuo YF, Shih YC, Giordano SH, Berenson AB. Trends in breast cancer mortality by stage at diagnosis among young women in the United States. Cancer. 2018 Sep 1;124(17):3500-9.

Lebovic GS. Oncoplastic Surgery: The Renaissance for Breast Surgery. Oncoplast Reconstr Breast Surg. 2019:3-12.

Mcguire KP. Breast Cancer in Young Women (Premenopausal Breast Cancer). Breast Disease. 2016:375-87.

Manzoor S, Anwer M, Soomro S, Kumar D. Presentation, diagnosis and management of locally advanced breast cancer: Is it different in low/middle income countries?. Pak J Medi Sci. 2019 Nov;35(6):1554.

Miller KD, Siegel RL, Lin CC, Mariotto AB, Kramer JL, Rowland JH, et al. Cancer treatment and survivorship statistics, 2016. CA: Cancer J Clini. 2016 Jul;66(4):271-89.

Bright CJ, Rea DW, Francis A, Feltbower RG. Comparison of quadrant-specific breast cancer incidence trends in the United States and England between 1975 and 2013. Cancer Epidemiol. 2016 Oct 1;44:186-94.

Bhatty I, Ibrahim M, Chaudhry ML. Complications after modified radical mastectomy in early breast cancer. Pak J Medi Sci. 2004;20(2):125-30.

Jan WA, Haq MI, ul Haq MA, Khan AS. Early complications of modified radical mastectomy with axillary clearance. J Postgrad Medi Instit. 2006;20(3).

Abass MO, Gismalla MD, Alsheikh AA, Elhassan MM. Axillary lymph node dissection for breast cancer: efficacy and complication in developing countries. J Global Oncol. 2018 Oct;4:1-8.

Ebner F, Friedl TW, de Gregorio A, Lato K, Bekes I, Janni W, et al. Seroma in breast surgery: all the surgeons fault?. Arch Gynecol Obstetr. 2018 Nov 1;298(5):951-9.

Zhang Z, Li L, Pang Y, Li Q, Guo C, Wang Y, et al. Comparison of harmonic scalpel and conventional technique in the surgery for breast cancer: A systematic review and meta-analysis. Ind J Cancer. 2018 Oct 1;55(4):348.

Merchant SJ, Chen SL. Prevention and management of lymphedema after breast cancer treatment. Breast J. 2015 May;21(3):276-84.

Cheadle WG. Risk factors for surgical site infection. Surgi Infect. 2006 Jan 1;7(S1):s7-11.

Lee CH, Chung SY, Kim WY, Yang SN. Effect of breast cancer surgery on chest tightness and upper limb dysfunction. Medicine. 2019 May;98(19).

Son D, Harijan A. Overview of Surgical Scar Prevention and Management. J Korean Medi Sci. 2014;29(6):751-7.




How to Cite

Melwani, R., Malik, S. J., Shakeel, S., Zafar, S., Khoso, M. Y., & Ali, S. N. (2020). Frequency of early post operative complications of modified radical mastectomy within period of four weeks. International Journal of Research in Medical Sciences, 8(5), 1838–1842.



Original Research Articles