Incidentally detected solid pseudopapillary neoplasm of pancreas in a child with an ovarian cyst: a case report

Sandeep M. Reddy, Siva K. Prasad, Shilpa B., Baleswari G.


Solid pseudopapillary neoplasms (SPN) are the most common as well as very rare pediatric tumors of the pancreas. Most of the literature is derived from adult SPNs. As per world health organization, these tumors considered as low grade malignant with excellent survival outcomes after complete surgical resection. We report a case of incidentally detected SPN in a 16-year-old female child with an ovarian cyst. She underwent pylorus preserving pancreaticoduodenectomy and ovarian cystectomy. Histopathology revealed well differentiated SPN of the pancreas head and ovarian cystadenoma. She is symptom-free at the 6th month follow up.


Pancreas, Pediatric, Solid pseudopapillary neoplsma

Full Text:



Martin RC, Klimstra DS, Brennan MF, Conlon KC. Solid-pseudopapillary tumor of the pancreas: a surgical enigma?. Ann Surg Oncol. 2002 Jan 1;9(1):35-40.

Papavramidis T, Papavramidis S. Solid pseudopapillary tumors of the pancreas: review of 718 patients reported in English literature. J Am Coll Surg. 2005 Jun 1;200(6):965-72.

Klöppel G, Hruban RH, Klimstra DS. Solid‐pseudopapillary neoplasm of the pancreas In WHO Classification of Tumors of the Digestive System. 5th ed. France: International Agency for Research on Cancer (IARC); 2019: 340-342.

Mao C, Guvendi M, Domenico DR, Kim K, Thomford NR, Howard JM. Papillary cystic and solid tumors of the pancreas: a pancreatic embryonic tumor? Studies of three cases and cumulative review of the world's literature. Surgery. 1995 Nov 1;118(5):821-8.

Bender AM, Thompson ED, Hackam DJ, Cameron JL, Rhee DS. Solid pseudopapillary neoplasm of the pancreas in a young pediatric patient: a case report and systematic review of the literature. Pancreas. 2018 Nov 1;47(10):1364-8.

Lee SE, Jang JY, Hwang DW, Park KW, Kim SW. Clinical features and outcome of solid pseudopapillary neoplasm: differences between adults and children. Arch Surg. 2008 Dec 15;143(12):1218-21.

Wang KS, Albanese C, Dada F, Skarsgard ED. Papillary cystic neoplasm of the pancreas: a report of three pediatric cases and literature review. J Pediatr Surg. 1998 Jun 1;33(6):842-5.

Jung SE, Kim DY, Park KW, Lee SC, Jang JJ, Kim WK. Solid and papillary epithelial neoplasm of the pancreas in children. World J Surg. 1999 Mar 1;23(3):233.

Vollmer Jr CM, Dixon E. Management of a solid pseudopapillary tumor of the pancreas with liver metastases. HPB. 2003 Nov 1;5(4):264-7.

Hwang J, Kim DY, Kim SC, Namgoong JM, Hong SM. Solid-pseudopapillary neoplasm of the pancreas in children: can we predict malignancy?. J Pediatr Surg. 2014 Dec 1;49(12):1730-3.

Park JY, Kim SG, Park J. Solid pseudopapillary tumor of the pancreas in children: 15-year experience at a single institution with assays using an immunohistochemical panel. Ann Surg Treat Res. 2014 Mar 1;86(3):130-5.

Strauss JF, Hirsch VJ, Rubey CN, Pollock M. Resection of a solid and papillary epithelial neoplasm of the pancreas following treatment with Cis‐platinum and 5‐fluorouracil: A case report. Medi Pediatr Oncol. 1993;21(5):365-7.

Ky A, Shilyansky J, Gerstle J, Taylor G, Filler RM, Grace N, et al. Experience with papillary and solid epithelial neoplasms of the pancreas in children. J Pediatr Surg. 1998 Jan;33(1):42-4.

Fried P, Cooper J, Balthazar E, Fazzini E, Newall J. A role for radiotherapy in the treatment of solid and papillary neoplasms of the pancreas. Cancer. 1985 Dec 15;56(12):2783-5.