Prevalence of vitamin D deficiency in patients with established coronary artery disease

Sapneet Kaur, Harleen Kaur, Susheel Kumar Sharma, Amarjeet Singh Bhatia


Background:Vitamin D deficiency is widely prevalent in this part of the country, in spite of the fact that there is ample sunshine and the economic status of the people is good. Several studies have suggested possible link between vitamin D deficiency and cardiovascular disease risk. Hence authors evaluated the patients with established coronary artery disease attending cardiology department of super speciality hospital, Government Medical College Jammu, for their vitamin D status.

Methods:The study was conducted in the department of Biochemistry Government Medical College Jammu and data of established cases of coronary artery disease patients attending cardiology department of super speciality hospital, government medical college Jammu was analyzed for vitamin D levels during the period from January 2019 to February, 2020.

Results: A total of 200 established cases of coronary artery disease comprising of 130 male patients and 70 female patients were analyzed in the study, out of 200 cases, 190 (95%) were found to be having low levels of vitamin D in their blood (<30 ngm/dl). 123 (94.6%) out of a total of 130 male patients had vitamin D deficiency as compared to 67 (95.7%) out of 70 females patients.

Conclusions:The study has revealed a very high prevalence of vitamin D deficiency in established cases of coronary artery diseases. More detailed prospective studies are required to unravel the association of vitamin D and its role in prevention of coronary artery diseases in the absence of well-established risk factors like smoking, Diabetes, Hypertension and dyslipidaemias.


Coronary artery disease, Prevalence, Vitamin D, Vitamin D deficiency

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Lappe JM, Travers-Gustafson D, Davies KM, Recker RR, Heaney RP. Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. Am J Clin Nutr. 2007 Jun 1;85(6):1586-91.

Grant WB, Garland CF. Evidence supporting the role of vitamin D in reducing the risk of cancer. J Inter Med. 2002 Aug;252(2):178-9.

Gorham ED, Garland CF, Garland FC, Grant WB, Mohr SB, Lipkin M, et al. Optimal vitamin D status for colorectal cancer prevention: a quantitative meta analysis. Am J Preven Med. 2007 Mar 1;32(3):210-6.

Grant WD, Garland CE. Vitamin D as a risk reduction factor for colorectal cancer. Am Family Phys. 2003 Feb 1;67(3):465.

Garland CF, Gorham ED, Mohr SB, Grant WB, Giovannucci EL, Lipkin M, et al. Vitamin D and prevention of breast cancer: pooled analysis. J Ster Biochem Mole Biol. 2007 Mar 1;103(3-5):708-11.

Dobnig H, Pilz S, Scharnagl H, Renner W, Seelhorst U, Wellnitz B, et al. Independent association of low serum 25-hydroxyvitamin D and 1, 25-dihydroxyvitamin D levels with all-cause and cardiovascular mortality. Archiv Inter Med. 2008 Jun 23;168(12):1340-9.

Holick MF. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr. 2004 Dec 1;80(6):1678S-88S.

Martini LA, Wood RJ. Vitamin D status and the metabolic syndrome. Nut Revi. 2006 Nov 1;64(11):479-86.

National Committee for Clinical Laboratory Standards. Procedures for handling and processing of blood specimens; approved guidelines- third edition. NCCLS Document H18-A3;Wayne (PA); NCCLS 2004;12.

Simpson R. Evidence for a specific 1, 25 -dihydroxy vitamin D 3 receptor in rat heart. Circulation. 1983;68:239.

Weishaar RE, Simpson RU. The involvement of the endocrine system in regulating cardiovascular function: emphasis on vitamin D3. Endo Revi. 1989 Aug 1;10(3):351-65.

Weishaar RE, Kim SN, Saunders DE, Simpson RU. Involvement of vitamin D3 with cardiovascular function. III. Effects on physical and morphological properties. Am J Physiol-Endocrinol Metab. 1990 Jan 1;258(1):E134-42.

Uysal S, Kalayci AG, Baysal K. Cardiac functions in children with vitamin D deficiency rickets. Pediat Cardiol. 1999 Jul 1;20(4):283-6.

Judd S, Tangpricha V. Vitamin D deficiency and risk for cardiovascular disease. Circulation. 2008 Jan 29;117(4):503.

Anderson JL, May HT, Horne BD, Bair TL, Hall NL, Carlquist JF, et al. Relation of vitamin D deficiency to cardiovascular risk factors, disease status, and incident events in a general healthcare population. Am J Cardiol. 2010 Oct 1;106(7):963-8.

Haider W, Zaib A, Abbasi A, Saleem A, Mir S, Shah BR, et al. Assessment of vitamin D status in general population of Muzaffarabad district and effect of supplementation on serum vitamin D levels in general population of Muzaffarabad district. J Nursing Health Sci. 2013;2(1):27-31.

Aggarwal R, Akhthar T, Jain SK. Coronary artery disease and its association with Vitamin D deficiency. J Mid-life Health. 2016 Apr;7(2):56.

Oberoi D, Mehrotra V, Rawat A. Vitamin D as a profile marker for cardiovascular diseases. Annal Car Anaesth. 2019 Jan;22(1):47.