Acute pancreatitis complicated by encephalopathy


  • Rajat Jhamb Department of Medicine, UCMS and GTB Hospital, New Delhi, India
  • Anant Parasher Department of Medicine, UCMS and GTB Hospital, New Delhi, India
  • Ashish Baweja Department of Medicine, UCMS and GTB Hospital, New Delhi, India



Acute Pancreatitis, Encephalopathy, Focal Neurological deficit, Pancreatic inflammation


Pancreatic encephalopathy is a frequently under-diagnosed and rare complication of acute pancreatitis. It denotes the occurrence of neuropsychiatric abnormalities in the setting of acute pancreatic inflammation, and presents with neurological symptoms that may persist even after the resolution of all metabolic parameters. Here we present the case of a 42 year old male patient presenting with altered sensorium and focal neurological deficit during the course of acute pancreatitis. The patient was treated conservatively, and later improved with supportive care.


Ruggieri RM, Lupo I, Piccoli F. Pancreatic encephalopathy: a 7-year follow-up case report and review of the literature. Neurolog Sci. 2002 Oct 1;23(4):203-5.

Akwe JA, Westney GE, Fongeh TS. Pancreatic encephalopathy. Am J Case Rep. 2008;9:399-403.

Sharf B, Bental E. Pancreatic encephalopathy. J Neurol Neurosurg Psychiatry. 1971;34(3):357-61.

Ding X, Liu CA, Gong JP, Li SW. Pancreatic encephalopathy in 24 patients with severe acute pancreatitis. Hepatobil Pancreat Dis Int. 2004 Nov;3(4):608-11.

Chen L, Zhang X. Pancreatic encephalopathy and Wernicke encephalopathy. Zhonghua Nei Ke Za Zhi. 2002 Feb;41(2):94-7.

Sun GH, Yang YS, Liu QS, Cheng LF, Huang XS. Pancreatic encephalopathy and Wernicke encephalopathy in association with acute pancreatitis: a clinical study. World J Gastroenterol. 2006;12(26):4224-4227.

Homma M, Suzuki H, Kusuhara H, Naito M, Tsuruo T, Sugiyama Y. High-affinity efflux transport system for glutathione conjugates on the luminal membrane of a mouse brain capillary endothelial cell line (MBEC4). J Pharmacol Exp Therap. 1999 Jan 1;288(1):198-203.

Pavelko KD, Van Engelen BG, Rodriguez M. Acceleration in the rate of CNS remyelination in lysolecithin-induced demyelination. J Neurosci. 1998 Apr 1;18(7):2498-505.

Leung PS. Local renin-angiotensin system in the pancreas: the significance of changes by chronic hypoxia and acute pancreatitis. J Pancre. 2001 Jan;2(1):3-8.

Leung PS, Carlsson PO. Tissue renin-angiotensin system: its expression, localization, regulation and potential role in the pancreas. J Molec Endocrinol. 2001 Jun 1;26(3):155-64.

Leung PS, Chan WP, Nobiling R. Regulated expression of pancreatic renin-angiotensin system in experimental pancreatitis. Molec Cellu Endocrinol. 2000 Aug 30;166(2):121-8.

Farkas G, Márton J, Nagy Z, Mándi Y, Takács T, Deli MA, et al. Experimental acute pancreatitis results in increased blood–brain barrier permeability in the rat: a potential role for tumor necrosis factor and interleukin 6. Neuroscie Let. 1998 Feb 20;242(3):147-50.

Tenenbein MS, Tenenbein M. Acute pancreatitis due to erythromycin overdose. Pediatr Emerg Care. 2005 Oct 1;21(10):675-6.

Ates F, Kosar F, Aksoy Y, Yldrm B, Sahin I, Hilmioglu F. QT interval analysis in patients with acute biliary pancreatitis. Pancreas. 2005 Oct 1;31(3):238-41.

Johnson DA, Tong NT. Pancreatic encephalopathy. Southern medical journal. 1977 Feb;70(2):165-7.

Ramanathan RS, Ahluwalia T. Acute necrotizing pancreatitis leading to pancreatic encephalopathy in a patient undergoing long-term continuous ambulatory peritoneal dialysis. J Acad Medi Sci. 2012 Apr 1;2(2):85-7.




How to Cite

Jhamb, R., Parasher, A., & Baweja, A. (2020). Acute pancreatitis complicated by encephalopathy. International Journal of Research in Medical Sciences, 8(6), 2319–2322.



Case Reports