Electrolyte disturbances and lipid profiles in ischaemic and hemorrhagic stroke patients in Aisyiyah Bojonegoro Hospital, Indonesia


  • Yunita Dwi Setyawati Department of Emergency, Aisyiyah Bojonegoro Hospital, Bojonegoro, Indonesia Faculty of Medicine and Health Sciences, Muhammadiyah University of Yogyakarta, Yogyakarta, Indonesia
  • Rila Ruis Mastura Department of Emergency, Aisyiyah Bojonegoro Hospital, Bojonegoro, Indonesia Faculty of Medicine, Sebelas Maret University, Surakarta, Indonesia




Acute stroke, Dyselectrolytemia, Electrolyte, Hypokalemia, Hyponatremia, Lipid, Low density lipoprotein, High density lipoprotein


Background: The prevalence of stroke continues to increase every year. Electrolyte imbalance and metabolic disorder can cause high morbidity and mortality of stroke. There are very few studies conducted on serum electrolytes and lipid levels in stroke patients. Authors aimed to know the electrolyte disturbance and lipid profiles in acute stroke.

Methods: Retrospective case analysis was used in this study. Patients who diagnosed with hemorrhagic and ischaemic stroke in Aisyiyah Bojonegoro Hospital from January to September 2019 were selected trough electronic medical records system. Authors examine the electrolyte levels and lipid profiles. Patients with a previous history of stroke, complication that might affect electrolyte level and incomplete data in medical records were excluded. Independent T-test or Mann Whitney test were used to analyze the difference of parameters between hemorrhagic and ischaemic stroke patients. P value was considered as significant at p<0.05.

Results: Most common electrolyte imbalance in both hemorrhagic and ischaemic stroke was hypokalemia which is statistically significant. Comparison between stroke patients was statistically significant for mean potassium and high density lipoprotein (HDL), while other mean serum values were not different. Potassium significantly lower (p=0.002) in hemorrhagic stroke and HDL significantly lower (p=0.034) in ischaemic stroke.

Conclusions: This study reveals that hypokalemia was higher in hemorrhagic stroke and HDL was lower in ischaemic stroke. Regular monitoring of lipid levels in patients with high risk factors and correction of electrolytes imbalance for stroke patients will help in decreasing the mortality and morbidity.


WHO, Global Health Observatory (GHO) data: NCD Mortality and Morbidity. Available at: https://www.who.int/gho/ncd/mortality_morbidity/en/. Accessed 26 August 2019.

WHO, Health Topics: Cardiovascular Diseases Available at: https://www.who.int/health-topics/cardiovascular-diseases/. Accessed 26 August 2019.

Kementrian Kesehatan RI. Hasil Utama Riskesdas 2018. Available at: https://www.kemkes.go.id/resources/download/info-terkini/hasil-riskesdas-2018.pdf. Accessed 26 August 2019.

Howard VL, Howard G. Distribution of Stroke: Heterogeneity by Age, Race, and Sex. In: Mohr JP, Grotta JC, Wolf PA, Moskowitz MA, Mayberg MR, Von Kummer R, eds. Stroke: Pathophysiology, Diagnosis and Management. 5th ed. Philadelphia, PA: Elsevier; 2011: 189-190.

Navarro JC, Bitanga E, Suwanwela N, Chang HM, Ryu SJ, Huang YN, Wong L, Arjundas D, Singhal BS, Lee SB, Yoon BW. Complication of acute stroke: A study in ten Asian countries. Neurol Asia. 2008 Jan 1;13(1):33-9.

Roy KS, Bandyopadhyay R, Paul R, Chakraborty S, Ray D, Mitra S, Mondal J, Biswas S. Study on serum and urinary electrolyte changes in cerebrovascular accident. J, Ind Acad Clini Medi. 2014 Apr;15(2):91-5.

Yaghi S, Elkind MS. Lipids and cerebrovascular disease: research and practice. Stroke. 2015 Nov;46(11):3322-8.

Kalyan M, Nahdi WK, Kanitkar SA, Moharkar A, Saha R. Electrolyte Imbalance In Acute Stroke. Nat J Integrat Res Medi. 2017 Jul 1;8(4).

Kembuan MAHN, Sekeon SAS. Electrolyte disturbances among acute stroke patients in Manado, Indonesia. GJMEDPH 2014;3(1).

Palm F, Urbanek C, Wolf J, Buggle F, Kleemann T, Hennerici MG. Etiology, risk factors and sex differences in ischemic stroke in the Ludwigshafen stroke study, a population-based stroke registry. Cerebrovasc Dis. 2012 Dec;33:69-75.

Orlandi G, Gelli A, Fanucchi S, Tognoni G, Acerbi G, Murri L. Prevalence of stroke and transient ischaemic attack in the elderly population of an Italian rural community. Eur J Epidemiol. 2003 Apr;18:879-82.

Boix R, del Barrio JL, Acosta J, Bergareche A, Bermejo-Pareja F, Gabriel R, et al, Stroke prevalence among the Spanish elderly: An analysis based on screening surveys. BMC Neurol. 2006 Oct;6(36):1-15.

Hassan AR, Aryan ZA. Electrolyte disturbance in hemorrhagic and non-hemorrhagic stroke patients in al-diwaniyah teaching hospital. Asian J Pharm Clin Res. 2018; 11(1):456-9.

WHO, Stroke: a global response is needed. Available at: https://www.who.int/bulletin/volumes/94/9/16-181636/en/. Accessed 20 December 2019.

Musa HH, Musa IH, El Sadig SM. Risk factors, electrolyte disturbances and lipid profiles in Sudanese patients with stroke. J Pub Health Epidemiol. 2015 Oct;7(10):324-30.

Sokrab TO, Sid-Ahmed FM, Idris MNA. Acute stroke type, risk factors, and early outcome in a developing country: a view from Sudan using a hospital-based sample. J Stroke Cerebrovasc Dis. 2002 Mar-Apr;11(2):63-5.

Habibi-koolaee M, Shahmoradi L, Niakan Kalhori SR, Ghannadan H, Younesi E. Prevalence of Stroke Risk Factors and Their Distribution Based on Stroke Subtypes in Gorgan: A Retrospective Hospital-Based Study-2015-2016. Neurol Res Internat. 2018;2018.

Tuttolomondo A, Pinto A, Salemi G, Di Raimondo D, Di Sciacca R, Fernandez P, et al. Diabetic and non-diabetic subjects with ischemic stroke: differences, subtype distribution and outcome. Nutrit, Metab Cardiovasc Dis. 2008 Feb 1;18(2):152-7.

Bandopadhyay M, Jatua SK, Adhikari M, Bhandari A. Study of electrolyte abnormality in acute stroke. Ann Intl Med Dental Res. 2017;3:4-9.

Farahmand S, Anzali BC, Heshmat R, Ghafouri HB, Hamedanchi S. Serum sodium and potassium levels in cerebro-vascular accident patients. Malays J Med Sci. 2013 May-Jul;20(3):39-43.

Saleem S, Yousuf I, Gul A, Gupta S, Verma S. Hyponatremia in stroke. Ann Indian Acad Neurol. 2014 Jan-Mar;17(1):55-7.

Chakraborty S, Ghosh K, Hazra R, Biswas RN, Ghosh S, Bhattacharya A, et al. Serum and urinary electrolyte levels in cerebro-vascular accident patients: a cross sectional study. Am J Inter Med. 2013 Dec;1(4):36-9.

Huang K, Hu Y, Wu Y, Ji Z, Wang S, Lin Z, et al. Hyperchloremia is associated with poorer outcome in critically Ill stroke patients. Front Neurol. 2018 Jul 3;9:485.

Green DM, RopperAH, Kronmal RA, Psaty BM, Burke GL. Serum potassium level and dietary potassium intake as risk factors for stroke. Neurology. 2002 Aug;59:314-20.

Khan MN, Hina DK, Mashood A, Umar M. Serum total and hdl-cholesterol in ischemic and hemorrhagic stroke. Ann Pak Inst Med Sci. 2014 Jan;10(1):21-5.




How to Cite

Setyawati, Y. D., & Mastura, R. R. (2020). Electrolyte disturbances and lipid profiles in ischaemic and hemorrhagic stroke patients in Aisyiyah Bojonegoro Hospital, Indonesia. International Journal of Research in Medical Sciences, 8(6), 2028–2032. https://doi.org/10.18203/2320-6012.ijrms20202238



Original Research Articles