Gaint cell tumour of phalynx: have you seen it?

Nuthan Jagadeesh, Sachin H. G., Vishwanath M. S., Arjun Mandri


Giant cell tumors are rarely seen in the foot. Only 1-2% cases of GCT occur in the foot. They can cause a significant amount of pain and deformity due to their aggressive and recurrent nature whenever it occurs in foot. We present an unusual case of a giant cell tumor of proximal phalynx of middle toe of left foot. 26 year old male came with complaints of pain and swelling over the middle toe of left foot since 6 months. Clinical and radiological features showed features consistent with GCT. Foot Function Index revealed a) Pain scale: 29 / 50 = 58%, b) Disability scale: 56 / 90 = 62%, c) Activity limitation scale: 8 / 30 = 27%. Authors performed enbloc resection with ray amputation of 3rd toe. Histopathological examination of excised specimen revealed classic findings of mononuclear cells with interspersed fibro-collagenous strands and numerous multinucleated osteoclast-like giant cells which confirmed our diagnosis. Patient was serially followed up and at 6 months followup, there were no signs of recurrence with markedly improved foot function index.


Gaint cell tumour, Gaint cells, Osteoclastoma, Phalynx, Ray amputation

Full Text:



Arslan G, Karaali K, Çubuk M, Gelen T, Lüleci E. Giant cell tumor of the fourth metacarpal bone. Clinical Imaging. 2000 May 1;24(3):139-42.

Bahalaik V, Anand S, Anderton JM. Giant cell tumour of the cuboid: A case report. Foot. 2001;11: 94-6.

Unni K, Inwards CY. Dahlin's bone tumours: general aspects and data on 10165 cases. 6th ed Philadelphia, P A: Lippincott Williams and Wilkins; 2010.

Niu X, Zhang Q, Hao L, Ding Y, Li Y, Xu H, et al. Giant cell tumor of the extremity: Retrospective analysis of 621 Chinese patients from one institution. J Bone Joint Surg Am. 2012;94:461-7.

Flavin RA, Landers R, Kelly IM, Kelly IP. Calcaneal Osteosarcoma. SICOT Online Report E035.

Alvarez Ramos A, Valverde Garcia JA, Garcia Alonso MG. Giant cell tumor of thefoot phalanges in children: a case report. J Pediatr Orthop B 1999;8(2):132-5.

Bapat MR, Narlawar RS, Pimple MK, Bhosale PB. Giant cell tumor of talar body. J Postgrad Med. 2000;46:110-1.

Budiman-Mak E, Conrad KJ, Roach KE. The Foot Function Index: a measure of foot pain and disability. J Clini Epidemiol. 1991 Jan 1;44(6):561-70.

Venditto T, Tognolo L, Rizzo RS, Iannuccelli C, Di Sante L, Trevisan M, et al. 17-Italian Foot Function Index with numerical rating scale: development, reliability, and validity of a modified version of the original Foot Function Index. Foot. 2015 Mar 1;25(1):12-8.

Turcotte RE. Giant cell tumor of bone. Orthop Clin North Am. 2006;37:35-51.

Huvos AG, ed. Bone Tumors: Diagnosis, Treatment, and Prognosis. 2nd ed. Philadelphia, PA: WB Saunders; 1998:429-467.

Eckardt JJ, Grogan TJ. Giant cell tumor of bone. Clin Orthop Relat Res. 1986;(204):45-58.

Wülling M, Engels C, Jesse N, Werner M, Delling G, Kaiser E. The nature of giant cell tumor of bone. J Cancer Res Clin Oncol. 2001;127:467-74.

Manfrini M, Stagni C, Ceruso M, Mercuri M. Fibular autograft and silicone implant arthroplasty after resection of giant cell tumor of the metacarpal. A case report with 9 year follow-up. Acta Orthop Scand. 2004;75:779-81.

Dridi M, Annabi H, Ben Ghozlen R, Abdelkefi M, Trabelsi M. Giant cell tumour of a phalanx in the foot: a case report. Acta Orthopædica Belgica. 2008 Apr 1;74(2):273-5.

Wu KK. Giant cell tumor of the foot. J Foot Surg. 1992;31:414-9.

O'Keefe RJ, O'Donnell RJ, Temple HT, Scully SP, Mankin HJ. Giant cell tumor of bone in the foot and ankle. Foot Ankle Inter. 1995 Oct;16(10):617-23.

Puri A, Agarwal M. Treatment of giant cell tumor of bone: Current concepts. Ind J Orthopaedics. 2007 Apr;41(2):101-8.

Wong KL, Nather A, Lim J, Kuang SL. Clinical outcomes of diabetic foot patients following ray amputation. Poster. InSixth International Symposium on the Diabetic Foot in Noordwijkerhout. Netherlands. 2011;2011.