Multiple sclerosis: making the invisibles visible


  • Bhupendra Chaudhary Department of Neurology, Jaswant Rai Super Speciality Hospital, Meerut, Uttar Pradesh, India
  • Ansh Chaudhary Department of Medicine, Bharati Vidyapeeth Medical College & Research Centre, Pune, Maharashtra, India



Multiple sclerosis (MS), a chronic inflammatory autoimmune disease with its protean manifestations commonly present as motor weakness, diplopia, visual loss, sensory symptoms in limbs or face or even bladder and bowel dysfunction. Underneath the umbrella of these common symptoms many invisible, unpredictable and erratic symptoms persists which complicates both the clinical presentation and the treatment. As majority of these symptoms are subjective so their true assessment on objective ground is difficult. It is important to consider that patients with MS and their care-takers should have reasonable knowledge about these symptoms because if these symptoms go unidentified or untreated then they may lead to a difficult diagnostic dilemma hence complicates further management.  The frequency and severity of these unusual symptoms at times raise a suspicion of other neurological diseases. The occurrence of any of these symptoms at times may be a sign of active disease.


Yetimalar Y, Secil Y, Inceoglu AK, Eren S, Basoglu M. Unusual primary manifestation of multiple sclerosis. N Z Med J. 2008;121(1277):47-59.

Evlice A, Demir T, Kaleagasi C Ozcan F, Demirkiran M., Rare onset symptoms in multiple sclerosis. Acta Belg 2016;71(3)154-7.

Sokić DV, Stojsavljević N, Drulović J, Dujmović I, Mesaroš Š, Ercegovac M, et al. Seizures in multiple sclerosis. Epilepsia. 2001 Jan 23;42(1):72-9.

Syndulko K, Jafari M, Woldanski A, Baumhefner RW, Tourtellotte WW. Effects of temperature in multiple sclerosis: a review of the literature. J Neurol Rehabilitat. 1996 Mar;10(1):23-34.

Attarian HP, Brown KM, Duntley SP, Carter JD, Cross AH. The relationship of sleep disturbances and fatigue in multiple sclerosis. Archi Neurol. 2004 Apr 1;61(4):525-8.

Lew-Starowicz M, Gianotten WL. Sexual dysfunction in patients with multiple sclerosis. Handbook Clini Neurol. 2015 Jan 1;130:357-70.




How to Cite

Chaudhary, B., & Chaudhary, A. (2020). Multiple sclerosis: making the invisibles visible. International Journal of Research in Medical Sciences, 8(6), 2371–2372.



Letter to the Editor