Morphological spectrum and epidemiological profile of ovarian tumours in black West African women at Lagos state university teaching hospital, Ikeja, Nigeria
Keywords:Age at diagnosis, Histological type, Ovarian tumour, World Health Organisation classification
Background: This study was done to evaluate the histological types, frequency and age distribution of ovarian tumours in Lagos State University Teaching Hospital (LASUTH), Ikeja, Lagos State. This study also aims to classify ovarian tumours in this centre according to the World Health Organisation (WHO).
Methods: A retrospective, descriptive hospital study of all ovarian specimens that were sent to the department of pathology and forensic medicine, LASUTH between 1st January, 2011 and 31st December, 2019 was done. Relevant data composed of the age distributions and histopathological types were extracted from the departmental information system and filed documents. The data was analysed using the IBM-SPSS version 25.0.
Results: There were 198 cases of ovarian tumours. The mean age at diagnosis of ovarian tumours was 34.6±15.3 years. Unilateral ovarian tumour was observed in 91.9%% of cases while bilateral disease was seen in 8.1%. Primary ovarian tumours constitute 97.0% of all diagnosed tumours of the ovary. Germ cell tumour was the most frequently diagnosed ovarian tumour; and teratoma was the most common, representing 91.2% of germ cell tumours and 47.0% of all ovarian tumours. Primary ovarian cancer peaked at the 6th decade of life and metastatic ovarian cancer was infrequently seen. Serous carcinoma is the most commonly diagnosed ovarian cancer.
Conclusions: Ovarian tumour presents most frequently at the 4th decade of life, and germ cell tumour is the most common.
Bray F, Ferlary J, Soerjomataram I, Siegel RL, Torre LA, Jermal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence mortality worldwide for 36 cancers in 185 countries. CA Cancer J Chin. 2018;68(6):394-424.
Kumbhakar D. Histopathological patterns of ovarian tumours: a hospital-based study. JMSCR. 2016;4:11215-9.
Patel AS, Patel JM, Shah KJ. Ovarian tumours- incidence and histopathological spectrum in tertiary care center, Valsad. IAIM. 2018;5(2):84-93.
Khan MA, Afzal S, Saeed H, Usman H, Ali R, Zain M, et al. Frequency of ovarian Tumours According to WHO Histological classification and their association to age at diagnosis. Annals KEMU. 2017;23(2):206-13.
Nishal AJ, Naik KS, Modi J. Analysis of spectrum of ovarian tumours: a study of 55 cases. Int J Res Med Sci. 2015;3(10):2714-7.
Ahmed M, Afroze N, Sabiha M. Morphological pattern of ovarian tumour: experience in a tertiary level hospital. J Bangladesh Coll Phys Surg. 2018;36:5-10.
Rabiu KA, Akinola OI, Adewunmi AA, Fabanwo AO, Adedeji MO, Popoola AO. Delays in presentation and management of ovarian cancer in Lagos, Nigeria. J Obstet Gynaecol. 2013;33(3):305-8.
Jarwani P, Babaria S, Suri SK, Patel SM, Doshi H. Analysis of distribution and patterns of ovarian lesions at a tertiary care hospital. Ann Pathol Lab Med. 2018;5(2):177-83.
Smith ER, XU XX. Ovarian ageing, follicle depletion, and cancer: a hypothesis for the aetiology of epithelial ovarian cancer involving follicle depletion. Lancet Oncol. 2008;9(11):1108-11.
Kuchenbecker KB, Hopper JL, Barnes, Phillips KA, Mooij TM, Roos-Blom MJ. Risks of breast, ovarian and contralateral breast cancer for BRCA1 AND BRCA 2 mutation carriers. JAMA. 2017;317(23):2402-16.
Sabageh D, Olaofe OO, Sabageh AO. An analysis of the clinicopathologic characteristics of ovarian tumours in Ile-Ife, Nigeria. Ann Trop Pathol. 2012;3(2):97-104.
Onyiaorah IV, Anunobi CC, Banjo AA, Fatima AA Nwankwo KC. Histopathological patterns of ovarian tumours seen in Lagos University teaching hospital: a ten-year retrospective study. Nig Q J Hosp Med. 2011;21(2):114-8.
Ajani MA, Aramide KO, Salami A, Okolo CA. Histopathological pattern of primary Ovarian neoplasms in South-Western Nigeria. Jos J Med. 2016;10(2):1-12.
Forae GD, Aligbe JU. Ovarian tumours among Nigerian females. A private practice experience in Benin-City, Nigeria. Adv Biomed Res. 2016;5:61.
Garg N, Anand AS, Annigeri C. Study of histomorphological spectrum of ovarian tumours. Int J of Med Health Res. 2017;3(10):12-20.
Iyokee CA, Ugwu GO, Ezugwu EC, Onah N, Ugwu O, Okafor O. Incidence, pattern and management of ovarian cancer at a tertiary medical center in Enugu. South East Nigeria. Ann Med Heath Sci Res. 2013;3(3):417-21.
Akakpo PK, Derkyi-Kwarteng L, Gyasi RK, Quayson SE, Anim JI. Ovarian cancer in ghana; a 10-year histopathological review of cases at korle bu teaching hospital. African J Reprod Health. 2015;19(4):102-6.
Yousif HM, Mohammed RA, Missawi HM, Elsawaf ZM, Albasri AM. Histopathological patterns of primary malignant ovarian neoplasms in different age group in Almadinah Almunawwarah region, KSA J Trubah Univer Med Sci. 2019;14(1):73-8.
Zayyam MS, Ahmed SA, Oguntayo AO, Kolawole AO, Olasinde TA. Epidemiology of ovarian cancers in Zaria, Northern Nigeria: a 10-year study. IJWH. 2017;9:855-60.
Ajani MA, Iyapo O, Salami A, Okolo CA. Secondary ovarian neoplasms in a tertiary hospital in South-Western Nigeria. Ann Ibd Pg Med. 2019;17(1):19-23.
Singh S, Saxena V, Khatri SL, Gupta S, Garewal J, Dubey K. Histopathological evaluation of ovarian tumours. Imperial J Interdisciplinary Res. 2016;2(4):435-9.
Tejeswini V, Reddy ES, Premarlatha P, Vahini G. Study of morphological patterns of ovarian neoplasms. J Dent Med Sci. 2013;10(6):11-6.