Langerhans cell histiocytosis of liver
DOI:
https://doi.org/10.18203/2320-6012.ijrms20203467Keywords:
Corona, Histiocyte, Immunohistochemistry, Langerhans cell histiocytosis, TransplantationAbstract
Langerhans cell histiocytosis (LCH) is a rare disorder of unknown etiology caused by proliferation of Langerhans cells. It can involve single organ system to multi organ systems and clinical presentation is variable depending on the organ involved and have different prognosis. LCH is common in children when compared to adults. Hepatic involvement in adults is relatively rare. Liver involvement has considerable impact on survival rates. Histopathology and immunohistochemistry provide the definitive diagnosis. Authors report a case of Langerhans cell histiocytosis in a young adult with hepatic involvement.
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Mansour MJ, Mokbel E, Fares E, Maddah J, Nasr F. Adult Langerhans cell histiocytosis with pulmonary and colorectoanal involvement: a case report. J Med Case Reports. 2017;11(1):272.
Rao S, Hegde S, Thilak PG, Babu GS, Ajila V, Shetty U, et al. Langerhans cell histiocytosis in a 5-year-old girl: a case report and review of literature. Indian J Med Paediatr Oncol. 2019;40(5):176.
Gadner H, Minkov M, Grois N, Pötschger U, Thiem E, Arico M, et al. Therapy prolongation improves outcome in multisystem Langerhans cell histiocytosis. Blood, The J Am Society Hematol. 2013;121(25):5006-14.
Egeler RM, De Kraker J, Voǔte PA. Cytosine‐arabinoside, vincristine, and prednisolone in the treatment of children with disseminated Langerhans cell histiocytosis with organ dysfunction: experience at a single institution. Med Pediatr Oncol. 1993;21(4):265-70.
Araujo B, Costa F, Lopes J, Castro R. Adult langerhans cell histiocytosis with hepatic and pulmonary involvement. Case Rep Radiol. 2015;2015.
Willman CL, Busque L, Griffith BB, Favara BE, McClain KL, Duncan MH, et al. Langerhans'-cell histiocytosis (histiocytosis X): a clonal proliferative disease. New Engl J Med. 1994;331(3):154-60.
Abla O, Egeler RM, Weitzman S. Langerhans cell histiocytosis: current concepts and treatments. Cancer Treat Rev. 2010;36(4):354-9.
Yağcı B, Varan A, Çağlar M, Söylemezoğlu F, Sungur A, Orhan D, et al. Langerhans cell histiocytosis: retrospective analysis of 217 cases in a single center. Pediatr Hematol Oncol. 2008;25(5):399-408.
Abdallah M, Généreau T, Donadieu J, Emile JF, Chazouillères O, Gaujoux-Viala C, et al. Langerhans’ cell histiocytosis of the liver in adults. Clin Res Hepatol Gastroenterol. 2011;35(6-7):475-81.
Favara BE. Histopathology of the liver in histiocytosis syndromes. Pediatr Pathol Lab Med. 1996;16(3):413-33.
Harmon CM, Brown N. Langerhans cell histiocytosis: a clinicopathologic review and molecular pathogenetic update. Arch Pathol Lab Med. 2015;139(10):1211-4.
Ma J, Jiang Y, Chen X, Gong G. Langerhans cell histiocytosis misdiagnosed as liver cancer and pituitary tumor in an adult: a case report and brief review of the literature. Oncol Letters. 2014;7(5):1602-4.
Griffiths W, Davies S, Gibbs P, Thillainayagam A, Alexander G. Liver transplantation in an adult with sclerosing cholangitis due to Langerhans cell histiocytosis. J Hepatol. 2006;44(4):829-31.
Degar BA, Fleming MD, Rollins BJ, Rodriguez-Galindo C. Histiocytosis. In: Orkin SH, Fisher DE, Ginsburg D, Look AT, Lux SE, Nathan DG, eds. Nathan and Oski’s Hematology and Oncology of Infancy and Childhood. 8th ed. Philadelphia, PA: Elsevier Saunders; 2015:2100-2122.
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