Evaluating the relationship between serum uric acid levels with Killip classification suggestive of left heart failure in acute myocardial infarction


  • Piyush Gosar Department of Medicine, GRMC, Gwalior, Madhya Pradesh, India
  • Sutakshee Sonwani Department of Medicine, GRMC, Gwalior, Madhya Pradesh, India
  • Pravi Gosar Ex-Resident, Sri Aurobindo Institute of Medical Sciences, Indore, Madhya Pradesh, India
  • Bhawana Rani Department of Medicine, GRMC, Gwalior, Madhya Pradesh, India




Complications, Heart failure, Risk factors, Serum uric acid level


Background: Present evidence shows that increased uric acid level is a negative prognostic factor in patients with moderate to severe heart failure. A study has highlighted a correlation between serum uric acid levels and Killip class in patients of acute myocardial infarction (AMI). Aim of this study the relationship between serum uric acid level and Killip classification in patients with AMI.

Methods: Sixty patients with AMI were studied prospectively in Department of Medicine/ Department of Cardiology, JA Group of Hospitals between 2016-2018. Patients were grouped based on the Killip class. Age, sex, history of smoking, alcohol consumption, hypertension and diabetes were recorded. Serum uric acid level were measured on Day 1, 3 and 5, which was compared with Killip class.

Results: Majority of the patients were males (65%) and had age between (28.3%) 51-60 years. No significant association was obtained between any risk factors of AMI and Killip’s class (p>0.05). Serum uric acid levels were significantly higher in Killip grade III (7.80±3.57) as compared to Killip’s grade II (6.64±2.88) and I (6.30±2.33) (p=0.014). Majority of the patients with Killip’s grades I and II, had uric acid level ≤7.0 mg/dl (n=18 and n=9 respectively) (p=0.040). Serum uric acid was equally distributed among different types of killip’s grades between patients who expired and survived. (p>0.05).

Conclusions: Serum uric acid levels has been found to be well correlated with Killip classification in patients with AMI. Combination of Killip class and serum uric acid level after AMI is a good predictor of mortality after AMI.


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How to Cite

Gosar, P., Sonwani, S., Gosar, P., & Rani, B. (2020). Evaluating the relationship between serum uric acid levels with Killip classification suggestive of left heart failure in acute myocardial infarction. International Journal of Research in Medical Sciences, 8(8), 2892–2896. https://doi.org/10.18203/2320-6012.ijrms20203433



Original Research Articles