Published: 2020-07-24

Study various clinical manifestations and biochemical parameter for liver dysfunction in association with Plasmodium vivax malaria

Bajranglal Banthia, Saad Mohammad Shakir


Background: Malaria is a parasitic disease which is majorly caused by the bite of an infected Anopheles mosquito. It has been estimated that the most common type of malaria affecting the human race is known as Plasmodium vivax. Human malaria is a global burden with 3.4 billion people at risk over 91 endemic countries. According to the WHO, the involvement of liver dysfunction in Plasmodium vivax malaria is not an uncommon phenomenon. Aim of the research was to study various clinical manifestations and biochemical parameter for liver dysfunction in association with Plasmodium vivax malaria.

Methods: It was an observational study carried out at Teerthanker Mahaveer Medical College and Research Centre, a tertiary care hospital situated in Moradabad for a period of 1 year (March 2017-Feb 2018). Total of 200 patients aged above 15 years, with either sex were part of it. All the patients having mixed malaria with dengue, pregnant women and the patients who did not give written consent for being a part of the study were excluded from the study. A detailed clinical examination was done, including all the hematological and biochemical examinations.

Results: The results depicted that the number of male patients was 95, and the number of female patients was 105. The majority of the patients belonged to 15-30 years of age group. The major clinical features of the patients suffering from P. Vivax were fever and jaundice. The number of patients with serum bilirubin >3 mg/dl was 55.

Conclusions: In light of the above results, it was evident that Plasmodium vivax has the capability of producing jaundice, hepatic dysfunction and anemia. The doctors must be very vigilant while treating the patients with Plasmodium vivax for any symptoms of jaundice as they are often misunderstood as hepatitis.


Liver dysfunction, Malaria, Plasmodium vivax, Serum bilirubin

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Kasliwal P, Rao MS, Kujur R. Plasmodium vivax malaria: An unusual presentation. Indian J Crit Care Med. 2009;13(2):103-5.

Lacerda MV, MourĂ£o MP, Coelho HC, Santos JB. Thrombocytopenia in malaria: who cares?. Memorias do Instituto Oswaldo Cruz. 2011 Aug;106:52-63.

Song JY, Park CW, Jo MY, Kim JY, Kim JH, Yoon HJ, et al. Two cases of Plasmodium vivax Malaria with the clinical picture resembling septic shock. Am J Trop Med Hyg. 2007;77:609-11.

Khatib Y, Patel R, Sequeira K, Agrawal G, Chikhale N. Hematological and biochemical alterations in malaria and their correlation with Parasitic Index. IOSR J Pharm. 2015;5(9):53-6.

John GK, Douglas NM, Von Seidlein L, Nosten F, Baird JK, White NJ, et al. Primaquine radical cure of Plasmodium vivax: a critical review of the literature. Malaria J. 2012 Dec;11(1):1-1.

Saha AK, Maitra S, Hazra SC. Comparison of hematological parameters between Plasmodium falciparum, Plasmodium vivax and control group. IJMRHS. 2014;3(1):120-7.

White NJ. Determinants of relapse periodicity in Plasmodium vivax malaria. Malaria J. 2011 Dec 1;10(1):297.

World Health Organization. World Malaria Report 2010. Available at: eng.pdf. Accessed 22 March, 2020.

Dhariyal KK, Farooq U, Singh S, Shariq M, Kaur N, Bharti AK. Malaria Positive Cases with Reference to Liver Function Test among Patients Attending in Teerthanker Mahaveer Medical College and Research Centre, Moradabad, Uttar Pradesh, India. Inter J Scientific Study. 2016 Mar 1;3(12):59-63..

Nigam AK, Gautam A, Gautam BK, Singh S. Profile of liver dysfunction in plasmodium vivax malaria. Inter J Contemp Med Res. 2017;4(8):1775-8.

Kochar DK, Das A, Kochar SK, Saxena V, Sirohi P, Garg S. Severe Plasmodium Vivax malaria: A report on serial cases from Bikaner in northwestern India. Am J Trop Med Hyg. 2009;80;194-8.

Mohapatra MK, Padhiary KN, Mishra DP, Sethy G, Atypical manifestations of Plasmodium vivax malaria. Indian J Malariol. 2002;39:18-25.

Biradar SM, Holyachi R. Study of clinical presentation of malaria and the associated liver profile changes in various species of plasmodia. Int J Res Med Sci. 2016;4(12):5447-51.

Khuraiya P, Sharma SS, Thakur AS, Pandey VP, Verma S. The study of clinical, biochemical and hematological profile in malaria patients. Int J Adv Med. 2016;3(2):209-17.