Study of thyroid function in patients with metabolic syndrome


  • Prema Ram Choudhary Department of Physiology, C.U. Shah Medical College, Surendranagar, Gujarat
  • Ramesh Chandra D. Jani Department of Physiology, C.U. Shah Medical College, Surendranagar, Gujarat



Metabolic syndrome, Thyroid stimulating hormone, Hypothyroidism, Central obesity


Background: Thyroid disease and the metabolic syndrome are both associated with cardiovascular disease. The aim of this study was to explore the study of thyroid function in patients with metabolic syndrome.

Methods: This cross-sectional study was conducted at department of physiology, M P shah medical college Jamnagar, Gujarat. It included 200 patients with metabolic syndrome (MetS) (National Cholesterol Education Program’s-Adult Treatment Panel III Criteria) in the study group and 100 subjects without metabolic syndrome in the control group. Anthropometric variables and blood pressure were taken using standardized technique and body mass index was calculated. Fasting blood sample was analyzed for total cholesterol (TC), triglycerides (TG), high density lipoproteins cholesterol (HDL-C), blood glucose (FBG) and TSH, T4 and T3 were measured using electro-chemiluminescence immuno assay. Statistical analysis was performed using SPSS windows version 20.0 software (SPSS Inc., Chicago, Illinois).

Results: The overall prevalence of thyroid dysfunction in patients with MetS was 41.5% with high prevalence of sub clinical hypothyroidism (27%). TSH (P<0.001) was significantly higher in the study group than in control group (P <0.01) but T3 and T4 values of study group were significantly lower than those of control group (P< 0.01). Metabolic components waist circumference, blood pressure, fasting blood glucose and triglycerides were significantly higher in metabolic subject (P<0.001), while HDL-C was significantly lower in study group (P<0.001) then control group. Conclusion:  Hypothyroidism brawny associated with components of metabolic syndrome, therefore increased multifaceted risk of cardiovascular disorders with elevate TSH levels.


Pandey S, Baral N, Majhi S, Acharya P, Karki P, Shrestha S, et al. Prevalence of the metabolic syndrome in acute myocardial infarction and its impact on hospital outcomes. Int J Diab Dev Ctries. 2009;29(2):52-5.

Shrestha S, Das BKL, Baral N, Chandra L. Association of metabolic syndrome and its components with thyroid dysfunction in females. Int J Diab DeV Ctries. 2007;(27):24-6.

Roos A, Bakker Stephan JL, Links Thera P, Gans Rijk OB, Wolffenbuttel Bruce HR. Thyroid Function Is Associated with Components of the Metabolic Syndrome in Euthyroid Subjects. J Clin Endocrinol Metab. 2007;92(2):491-6.

Ghanshyam P, Subash S, Anita A, Kumar V. Association between primary hypothyroidism and metabolic syndrome and the role of C reactive protein: a cross–sectional study from South India. Thyroid Research. 2009;2(2):1-7.

Executive summary of the third report of the national cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA. 2001;285:2486.

MacKay NJ. Scaling of human body weight with height; the Body Mass Index revisited, J. of Biomechanics. 2009;43:764-66.

Friendewald WT, Levy RI and Fredricksin DS. Estimation of the concentration of low density lipoprotein in plasma, without use of the preparative ultra-centrfugation. Clin. Chem. 1972;18:499-502.

Bahn Chair RS, Burch HB, Cooper DS, Garber JR, Greenlee MC, Klein I, et al. Hyperthyroidism and other causes of thyrotoxicosis: management guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists. Thyroid. 2011;21(6):593-646.

Meher LK, Raveendranathan SK, Kota SK, Sarangi J, Jali SN. Prevalence of hypothyroidism in patients of metabolic syn¬drome. Thyroid Res Pract. 2013;10:60-4.

Shantha GP, Kumar AA, Jeyachandran V, Rajamanickam D, Rajkumar K, Salim S, et al. Association between primary hypothyroidism and metabolic syndrome and the role of C reactive protein: a cross-sectional study from South India. Thyroid Res. 2009;2:2.

Wang JY, Wang CY, Pei D, Lai CC, Chen YL, Wu CZ, et al. Association between thyroid function and metabolic syndrome in elderly subjects. J Am Geriatr Soc. 2010;58:1613-4.

Gyawali P, Takanche JS, Shrestha RK, Bhattarai P, Khanal K, Risal P, et al. Pattern of Thyroid Dysfunction in Patients with Metabolic Syndrome and Its Relationship with Components of Metabolic Syndrome, Diabetes Metabolism J. 2015;39:66-73

Garcia GJ, Alvirde-Garcia U, Lopez-Carrasco G, Padilla Mendoza ME, Mehta R, Arellano-Campos O, et al. TSH and free thyroxine concentrations are associated with differing metabolic markers in euthyroid subjects. Eur J Endocrinol. 2010;163:273-8.

McLaughlin T, Abbasi F, Cheal K, Chu J, Lamendola C, Reaven G. Use of metabolic markers to identify overweight individuals who are insulin resistant. Ann Intern Med. 2003;139:802-9.

Reaven G. Metabolic syndrome: pathophysiology and implications for management of cardiovascular disease. Circulation. 2002;106:286-8.

Oh JY, Sung YA, Lee HJ. Elevated thyroid stimulating hormone levels are associated with metabolic syndrome in euthyroid young women. Korean J Intern Med. 2013;28:180-6.




How to Cite

Choudhary, P. R., & Jani, R. C. D. (2017). Study of thyroid function in patients with metabolic syndrome. International Journal of Research in Medical Sciences, 4(6), 2024–2029.



Original Research Articles