Mediastinitis as a complication of Epstein-Barr virus infection: a rare entity

Shifa Younus, Hamza Maqsood, Amna Younas


Epstein-Barr virus (EBV) is a member of the herpes virus family that can infect humans. Common manifestations of Epstein-Barr virus infection include fever, lymphadenopathy and pharyngitis with some rare complications including mediastinitis, myocarditis, pancreatitis, acute kidney failure and neurological disorders. Clinical findings along with serological evidences are needed to diagnose the infection. Early investigation for EBV in febrile patients can expedite both diagnosis and treatment.


Mediastinitis, EBV, Emphysema, Peri-tonsillar abscess

Full Text:



Glynn FJ, Mackle T, Kinsella J. Upper airway obstruction in infectious mononucleosis. Eur J Emerg Med. 2007;14(1):41-2.

Bennett JE, Dolin R, Blaser MJ. Mandell, Douglas, and Bennett’s principles and practices of infectious diseases, 8th ed. Churchill Livingstone, Philadelphia, PA. 2015.

Andrianakis IA, Kotanidou AN, Pitaridis MT, Saroglou GJ, Exarhos DN, Roussos CS, Bellenis IP. Life-threatening bilateral empyema and mediastinitis complicating infectious mononucleosis. Intensive Care Med. 2002;28:663-4.

Kristensen LH, Prag J. Human necrobacillosis, with emphasis on Lemierre’s syndrome. Clin Infect Dis. 2000;31:524-32.