The anti-synthetase syndrome in a type 1 diabetes


  • Kshithija Sajjan Department of Medicine, Dr. DY Patil Medical College and Vidyapeeth, Pune, Maharashtra, India
  • Anuj Pahuja Department of Medicine, Dr. DY Patil Medical College and Vidyapeeth, Pune, Maharashtra, India
  • Yadav Ponvijaya Department of Medicine, Dr. DY Patil Medical College and Vidyapeeth, Pune, Maharashtra, India
  • Manoj Prakash Jeyaseelan Department of Medicine, Dr. DY Patil Medical College and Vidyapeeth, Pune, Maharashtra, India



Anti synthetase syndrome, Anti Jo1 syndrome, Dermatomyositis


Anti-synthetase syndrome is an autoimmune disease associated with interstitial lung disease (ILD), dermatomyositis and polymyositis. It has been recognized as an important cause of autoimmune inflammatory myopathy in a subset of patients with dermatomyositis. 37-year-old male, known case of type 1 diabetes mellitus, came with complaints of: generalized anasarca, pain in both knees, ankles, wrist and small joints of fingers. He also had dyspnoea on exertion, chronic non-productive cough, and fever off and on, all for 1 month. Initially all involvement was attributed to diabetes. For joint pain an antinuclear antibodies (ANA) was sent. He turned out to be anti-Jo1, antibody positive. Rash on hands was diagnosed by dermatologist as, mechanic’s hand, hence diagnosed as an inflammatory myopathy with dermatomyositis anti-synthetase syndrome. Patient was successfully treated with immunosuppressants and supportive treatment and responded to tablet Prednisolone and Mycophenolate mofetil. The patient had one major and 2 minor criteria-ILD, arthritis and Mechanic’s hand and anti-Jo 1 antibody positive. Thus, diagnosed as anti-synthetase syndrome with type 1 diabetes mellitus.


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How to Cite

Sajjan, K., Pahuja, A., Ponvijaya, Y., & Jeyaseelan, M. P. (2020). The anti-synthetase syndrome in a type 1 diabetes. International Journal of Research in Medical Sciences, 8(10), 3749–3752.



Case Reports