Single dose surfactant early rescue therapy in respiratory distress syndrome-experience and outcome at a tertiary care centre

Authors

  • Keerti Swarnkar Department of Pediatrics, Jawaharlal Nehru medical college, sawangi (m), wardha, Maharashtra
  • Manish Swarnkar Department of general surgery, Jawaharlal Nehru medical college, sawangi (m), wardha, Maharashtra

DOI:

https://doi.org/10.18203/2320-6012.ijrms20161769

Keywords:

Respiratory distress syndrome, Early rescue, Surfactant, Ventilatory parameters, Fraction of inspired oxygen

Abstract

Background: Neonatal respiratory distress syndrome (RDS) is a progressive respiratory failure that is caused primarily by a deficiency of pulmonary surfactants (PS). We undertook a prospective study to evaluate outcomes of neonatal respiratory distress syndrome (RDS) patients treated with early rescue pulmonary surfactant.

Methods: This was a prospective cross sectional study conducted at level III NICU. A total of 47 eligible  patients out of 142 diagnosed RDS on chest x-ray or FiO2 ≥40 was needed to reach SpO2 between 85 and 93%  received early recue surfactant therapy (within 2hrs of life) and  maternal ,neonatal and clinical data was analysed using SPSS software.

Results: In this study prevalence of RDS amongst neonates admitted in NICU was 16.4%, early rescue surfactant therapy could be given only to 47 cases. There was male predominance (2.62:1). Mean age of administration of surfactant was 1.30±0.8 hr and Antenatal steroid was given in only 21.3% of mothers. Fraction of inspired oxygen concentration (Fio2) requirement also significantly decreases before and after therapy (p value˂0.0001) at 6,12, and 24 hrs. PEEP also shows decreasing trend at 24 hrs (p value ˂0.05). Sepsis was the commonest complication leading to mortality.

Conclusion: Implementation of early rescue administration of surfactant in infants at high risk for developing RDS in neonatal ICU is a safe and effective modality of respiratory support which decreases ventilatory requirements, improves respiratory status, and causes early extubation.

 

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Published

2017-01-02

How to Cite

Swarnkar, K., & Swarnkar, M. (2017). Single dose surfactant early rescue therapy in respiratory distress syndrome-experience and outcome at a tertiary care centre. International Journal of Research in Medical Sciences, 4(6), 2107–2111. https://doi.org/10.18203/2320-6012.ijrms20161769

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Original Research Articles