Published: 2020-10-28

Meibomian gland carcinoma of the lower eyelid: a rare case

Madhusmita Behera, Subhra Dhar


Meibomian gland carcinoma (MGC) is a rare but highly malignant slow growing tumor of the eyelid. MGC usually arises from meibomian gland located in the tarsal plate although rarely it can originates in the gland of zeis, sebaceous gland of caruncle, and periocular skin. MGC is more common in cases of elderly females. Upper eyelid is more commonly affected where the meibomian glands are more. Early diagnosis is very important but in most of the cases the diagnosis is delayed as it mimics chalazion or blepharo-conjunctivitis. This leads to inappropriate treatment and increase in morbidity and/or mortality. Special feature of this carcinoma is that it spread intra-epithelial and causes skipped lesions.


Eyelid, Meibomian gland carcinoma, Malignant

Full Text:



Ni C, Kou PA, meibomian gland carcinoma: A clinicopathological study of 156 cases with long period follow up 100 cases. Jpn J Ophthalmol. 1979;23:388-401.

Khan JA, Doane JF, Grove AS. Sebaceous and meibomian carcinoma of the eye lid. Recognition, diagnosis and management. Ophthal Plastic Reconstructive Surg. 1991;7(1);61-3.

Zurcher M, Hintscich CR, Garner A, Bunce C, Collin JRO. Sebaceous carcinoma of the eyelid: aclinico pathological study. Br J Opthalmol. 1998;82:1049-53.

Rao NA, Hidayat AA, Mc Lean IW, Zimmerman LE. Sebaceous carcinoma of the ocular adenexa: a clinicopathologic study of 104 cases with five years follow up date. Human Pathol. 1982;13:122.

Enomoto E, Kamure Y, Nohara M, Kanako A, Suji HT, Hasegawe H, Sugitani M. a case of giant sebaceous gland carcinoma with adequate treatment. Nippon Ganka Gakki Zasshi. 2000;104(10):740-5.

Foster CS, Allansmith MR, chronic unilateral blepharo conjunctivitis causes by sebaceous carcinoma Am J Ophthalmol. 1978;86:218-20.

Sweebe EC, Cogan DG. Adenocarcinoma of the meibomian gland, a pseudochalazion entity. AMA Arch Ophthalmol. 1959;61:282-90.

Condon GP, Brownstein S, Codere F. Sebaceous carcinoma of the eyelid masquerading. Ophthalmol. 1985;103:1525-9.

Muquit MM, Roberts F, Lee WR, Kemp E. Improved survival rates in sebaceous carcinoma of the eyelid. Eye (Lond). 2004;18:49-53.

Epstein GA, Putterman AM. Sebaceous adenocarcinoma of the eyelid. Ophthalmic Surg. 1983;14:935-40.