Hypereosinophilia presented as thromboembolic event: a rare manifestation

Authors

  • Sudhir K. Atri Department of General Medicine, Pt B.D Sharma PGIMS, University of Health Sciences, Rohtak, Haryana, India
  • Homdutt . Department of General Medicine, Pt B.D Sharma PGIMS, University of Health Sciences, Rohtak, Haryana, India
  • Manjri Goel Department of General Medicine, Pt B.D Sharma PGIMS, University of Health Sciences, Rohtak, Haryana, India
  • Devender Yadav Department of General Medicine, Pt B.D Sharma PGIMS, University of Health Sciences, Rohtak, Haryana, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20204917

Keywords:

Eosinophilia, Deep vein thrombosis, Pulmonary embolism, Thromboembolism

Abstract

Eosinophilia refers to peripheral blood absolute eosinophil count above the ULN, normal range of AEC is 0.05-0.5× 109/l (1-6%). Hyper eosinophilia refers to AEC above 1.5×109/l. Hypereosinophilia can affect multiple organs and can cause cardiomyopathy, gastroenteritis, cutaneous lesions, pneumonitis, and neuritis. In addition, some patients develop thromboembolic complications. We are presenting a case who presented to us with thromboembolic complication later diagnosed as hypereosinophilia with Bone marrow showing myeloid associated eosinophilia (Primary eosinophilia).

Author Biographies

Sudhir K. Atri, Department of General Medicine, Pt B.D Sharma PGIMS, University of Health Sciences, Rohtak, Haryana, India

Senior professor

Department of General Medicine

Homdutt ., Department of General Medicine, Pt B.D Sharma PGIMS, University of Health Sciences, Rohtak, Haryana, India

Junior resident

Department of General Medicine

Manjri Goel, Department of General Medicine, Pt B.D Sharma PGIMS, University of Health Sciences, Rohtak, Haryana, India

Assitant Professor

Department of General Medicine

Devender Yadav, Department of General Medicine, Pt B.D Sharma PGIMS, University of Health Sciences, Rohtak, Haryana, India

Junior resident

Department of General Medicine

References

Lippi GI, Montagnana M, Salvagno GI, Franchini M, Targher G, Guidi GC, Eosinophilia and first-line coagulation testing, J. Thromb Haemost. 2013;11 (3):412–22.

Bain BJ. Chronic eosinophilic leukemia, not otherwise specified. World Health Organization Classification of Tumors of Haematopoietic and Lymphoid Tissues. 2008:51-3.

Sato Y, Fukunaga T, Hayashi T, Asada Y. Hypereosinophilic syndrome associated with occlusive coronary thrombosis and right ventricular thrombus. Pathol Int. 2008;58:138-41.

Uemura K, Nakajima M, Yamauchi N, Fukayama M, Yoshida K. Sudden death of a patient with primary hypereosinophilia, colon tumours, and pulmonary emboli. J Clin Pathol. 2004;57:541-3.

Sherer Y, Salomon O, Livneh A, Pras M, Langevitz P. Thromboembolism in a patient with transient eosinophilia and thrombocytopenia. Clin Lab Haematol. 2000;22:247-9.

Klion AD, Bochner BS, Gleich GJ, Nutman TB, Rothenberg ME, Simon HU, et al. Hypereosinophilic Syndromes Working Group. Approaches to the treatment of hypereosinophilic syndromes: a workshop summary report. J Aller Clinic Immunol. 2006;117(6):1292-302.

Roufosse F, Weller PF. Practical approach to the patient with hypereosinophilia. J Aller Clinic Immunol. 2010;126(1):39-44.

Mukai HY, Ninomiya H, Ohtani K, Nagasawa T, Abe T. Major basic protein binding to thrombomodulin potentially contributes to the thrombosis in patients with eosinophilia. Brit J Haematol. 1995;90(4):892-9.

Baccarani M, Cilloni D, Rondoni M, Ottaviani E, Messa F, Merante S, et al. The efficacy of imatinib mesylate in patients with FIP1L1-PDGFRα-positive hypereosinophilic syndrome. Results of a multicenter prospective study. Haematol. 2007;92(9):1173-9.

Walz C, Erben P, Ritter M, Bloor A, Metzgeroth G, Telford N, et al. Response of ETV6-FLT3–positive myeloid/lymphoid neoplasm with eosinophilia to inhibitors of FMS-like tyrosine kinase 3. Blood, The Journal of the American Society of Hematology. 2011;118(8):2239-42.

Downloads

Published

2020-10-28

How to Cite

Atri, S. K., ., H., Goel, M., & Yadav, D. (2020). Hypereosinophilia presented as thromboembolic event: a rare manifestation. International Journal of Research in Medical Sciences, 8(11), 4127–4129. https://doi.org/10.18203/2320-6012.ijrms20204917

Issue

Section

Case Reports