Neurological manifestations in COVID-19 infection
DOI:
https://doi.org/10.18203/2320-6012.ijrms20204928Keywords:
Coronavirus disease, COVID-19, Neurological manifestation, NeurologyAbstract
The emerge of coronavirus disease 2019 (COVID-19), previously known as novel coronavirus (2019-nCoV), in Wuhan, China, in December 2019, has spread throughout the world. COVID-19 is known to cause respiratory disease. However, several scientific studies have shown nervous system involvement in COVID-19 infection. The potential mechanisms of this infectious disease transmission to the brain are through infected olfactory epithelium, hematogenous spread and immune-related pathway. Nervous system involvement in COVID-19 infection can be classified as central nervous system (CNS) involvement, peripheral nervous system involvement (PNS) and muscle. CNS involvement, including headache, cerebrovascular disease, impaired consciousness, meningitis, encephalitis, dizziness and seizure. PNS manifestations, such as anosmia, ageusia or dysgeusia, oculomotor nerve palsy and Guillain-Barre syndrome (GBS). Myalgia or arthralgia is the most common presentation of muscle involvement in COVID-19 infection. This review concludes that neurological disorders as COVID-19 clinical features must be recognized by medical professionals in order to have appropriate diagnosis and treatment so that COVID-19 patients can have better prognosis.
References
World Health Organization. Timeline: WHO’s COVID-19 response. 2020. Available at: https://www.who.int/emergencies/diseases/novel-coronavirus-2019/interactive-timeline#event-51. Accessed on: 02 September 2020.
Guo YR, Cao QD, Hong ZS, Tan YY, Chen SD, Jin HJ, et al. The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status. Mil Med Res. 2020;7:11.
World Health Organization. WHO coronavirus disease (COVID-19) dashboard. 2020. Available at: https://covid19.who.int. Accessed on: 02 September 2020.
Ahmed MU, Hanif M, Ali MJ, Haider MA, Kherani D, Memon GM, et al. Neurological manifestations of COVID-19 (SARS-CoV-2): A Review. Front Neurol. 2020;11.
Vellas C, Delobel P, Barreto PDS, Izopet J. COVID-19, virology and geroscience: a perspective. J Nutr Health Aging. 2020;24(7):685-91.
Shi Y, Wang G, Cai XP, Deng, JW, Zheng L, Zhu HH, et al. An overview of COVID-19. Journal of Zhejiang University-Science B (Biomed Biotech). 2020;21(5):343-60.
Kannan S, Ali PSS, Sheeza A, Hemalatha K. COVID-19 (novel coronavirus 2019)-recent trends. Eur Rev Med Pharmacol Sci. 2020;24:2006-11.
Kwong KCNK, Mehta PR, Shukla G, Mehta AR. COVID-19, SARS and MERS: a neurological perspective. J Clin Neurosci. 2020;77:13-6.
Chen X, Laurent S, Onur OA, Kleineberg NN, Fink GR, Schweitzer F, et al. A systematic review of neurological symptoms and complications of COVID-19. J Neurol. 2020;1-11.
Fan H, Tang X, Song Y, Liu P, Chen Y. Influence of COVID-19 on cerebrovascular disease and its possible mechanism. Neuropsychiatr Dis Treatment. 2020;16:1359-67.
Roman GC, Spencer PS, Reis J, Buguet A, Faris MEA, Katrak SM, et al. The neurology of COVID-19 revisited: a proposal from the environmental neurology specialty group of the world federation of neurology to implement international neurological registries. J Neurol Sci. 2020;414.
Mao L, Jin H, Wang M, Hu Y, Chen S, He Q, et al. Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. Jama Neurol. 2002;77(6):683-90.
Guan W, Ni Z, Hu Y, Liang W, Ou C, He J, et al. Clinical characteristics of coronavirus disease 2019 in China. New Engl J Med. 2020;382:1708-20.
Xu XW, Wu XX, Jiang XG, Xu KJ, Ying LJ, Ma CL, et al. Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series. BMJ. 2020;368.
Bhatraju PK, Ghassemieh BJ, Nichols M, Kim R, Jerome KR, Nalla AK, et al. Covid-19 in critically ill patients in the Seattle region - case series. New Engl J Med. 2020;382(21):2012-22.
Toptan T, Aktan C, Basari A, Bolay H. Case series of headache characteristics in COVID-19: headache can be an isolated symptom. Am Headache Soc. 2020:1788-92.
Gklinos P. Neurological manifestations of COVID-19: a review of what we know so far. J Neurol. 2020;267(9):2485-9.
Hess DC, Eldahshan W, Rutkowski E. COVID-19-related stroke. Translational Stroke Res. 2020;11:322-5.
Li Y, Li M, Wang M, Zhou Y, Chang J, Xian Y. Acute cerebrovascular disease following COVID-19: a single center, retrospective, observational study. 2020; Stroke Vasc Neurol. 2020;5(3):279-84.
Helms J, Kremer S, Merdji H, Clere-Jehl L, Schenck M, Kummerlen C, et al. Neurologic features in severe SARS-CoV-2 infection. New Engl J Med. 2020;382(23):2268-70.
Moriguchi T, Harii N, Goto J, Harada D, Sugawara H, Takamino J, et al. A first case of meningitis/encephalitis associated with SARS-coronavirus-2. Int J Infect Dis. 2020;94:55-8.
Gallacher SD, Seaton A. Meningococcal meningitis and COVID-19 co-infection. BMJ Case Rep. 2020;13(8).
Mardani M, Nadji SA, Sarhangipor KA, Sharifi-Razavi A, Baziboroun M. COVID-19 infection recurrence presenting with meningoencephalitis. New Microbe and New Infect. 2020;37:100732.
Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical Characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020;323(11):1061-9.
Correia AO, Feitosa PWG, Moreira JLDS, Nogueira SAR, Fonseca RB, Nobre MEP. Neurological manifestations of COVID-19 and other coronaviruses: a systematic review. Neurol Psychiatr Brain Res. 2020;37:27-32.
Lahiri D, Ardila A. COVID-19 pandemic: a neurological perspective. Cureus. 2020;12(4):7889.
Huang S, Wu C, Jia Y, Li G, Zhu Z, Lu K, et al. COVID-19 outbreak: the impact of stress on seizures in patients with epilepsy. Epilepsia. 2020.
Alkhotani A, Siddiqui MI, Almuntashri F, Baothman R. The effect of COVID-19 pandemic on seizure control and self-reported stress on patient with epilepsy. Epilepsy Behav. 2020;112:107323.
Anand P, Al-Faraj A, Sader E, Dashkoff J, Abdennadher M, Murugesan R, et al. Seizure as the presenting symptom of COVID-19: a retrospective case series. Epilepsy Behav. 2020;112:107335.
Meng X, Deng Y, Dai Z, Meng Z. COVID-19 and anosmia: a review based on up-to-date knowledge. Am J Otolaryngol. 2020;41(5):102581.
Sungnak W, Huang N, Becavin C, Berg M, Queen R, Litvinukova M, et al. SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes. Nature Med. 2020;26:681-7.
Fiani B, Covarrubias C, Desai A, Sekhon M, Jarrah R. A contemporary review of neurological sequelae of COVID-19. Front Neurol. 2020;11:640.
Macera M, Angelis GD, Sagnelli C, Coppola N. COVID-19 Group V. Clinical presentation of COVID-19: case series and review of literature. Int J Environ Res Public Health. 2020;17(4):5062.
Luers JC, Rokohl AC, Loreck N, Matos PAW, Augustin M, Dewald F, et al. Olfactory and gustatory dysfunction in coronavirus disease 19 (COVID-19). Clin Infect Dis. 2020;525.
Bagheri SHR, Asghari AM, Farhadi M, Shamshiri AR, Kabir A, Kamrava SK, et al. Coincidence of COVID-19 epidemic and olfactory dysfunction outbreak. Medical Journal of The Islamic Republic of Iran. 2020.
Xu H, Zhong L, Deng J, Peng J, Dan H, Zeng X, et al. High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa. Int J Oral Sci. 2020;12(8).
Vaira LA, Salzano G, Fois AG, Piombino P, Riu GD. Potential pathogenesis of ageusia and anosmia in COVID-19 patients. Int Forum Allergy Rhinol. 2020;10(9):1103-4.
Wei H, Yin H, Huang M, Guo Z. The 2019 novel coronavirus pneumonia with onset of oculomotor nerve palsy: a case study. J Neurol. 2020;267:1550-3.
Malek E, Salameh J. Guillain-barre syndrome. Semin Neurol. 2019;39(5):589-95.
Rahimi K. Guillain-barre syndrome during COVID-19 pandemic: an overview of the reports. Neurol Sci. 2020;1-8.
Caress JB, Castoro RJ, Simmons Z, Scelsa SN, Lewis RA, Ahlawat A, et al. COVID-19-associated guillain-barre syndrome: the early pandemic experience. Muscle & Nerve 2020;1-7.
Sanctis PD, Doneddu PE, Vigano L, Selmi C, Nobile-Orazio E. Guillain barre syndrome associated with SARS-CoV-2 infection. a systematic review. Eur J Neurol. 2020.
