A case control study of serum vitamin D levels in alopecia areata

Bobbili Tarun Kesava Naidu; Kavya Baddireddy

doi:10.18203/2320-6012.ijrms20204227

Authors

Bobbili Tarun Kesava Naidu Department of General Medicine, GVP Institute of Health Care and Medical Technology, Visakhapatnam, Andhra Pradesh, India.
Kavya Baddireddy Department of Dermatology, Venereology and Leprology, GVP Institute of Health Care and Medical Technology, Visakhapatnam, Andhra Pradesh, India.

DOI:

https://doi.org/10.18203/2320-6012.ijrms20204227

Keywords:

Alopecia areata, Vitamin D, 25-Hydroxyvitamin D, Severity of alopecia tool score

Abstract

Background: Alopecia areata is an autoimmune disorder of anagen hair follicle leading to distressing and relapsing non-scarring hair loss. Vitamin D is an immunomodulator and plays a role in regulating normal hair cycle. Recent evidence suggests inconsistent association between vitamin D deficiency and alopecia areata.

Methods: This case control study included 70 newly diagnosed cases of alopecia areata and 70 healthy controls. Competitive chemiluminescence immunoassay was used to determine and compare the serum vitamin D (25‑hydroxyvitamin D) levels between these groups. Also, the serum vitamin D levels correlation with severity of the disease was studied. ANOVA test and student t test were used for the statistical analysis.

Results: Serum Vitamin D levels were significantly decreased in alopecia areata patients than in controls (p<0.05). There was no stastically significant relationship between serum 25-OH Vitamin D levels and severity of the disease (p=0.06).

Conclusions: Prevalence of serum 25 (OH) deficiency was significantly higher in alopecia areata group. However no significant relation was found with disease severity.

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