Prevalence of vitamin D deficiency in patients of hypertensive disorders of pregnancy and normal pregnant women

Asha Sharma, Jaya Choudhary, Piyush Joshi, Neha Bardhar


Background: The aim of this study was to compare vitamin D level in normal pregnant women and patients of hypertensive disorders of pregnancy and to study the prevalence of vitamin D deficiency in patients of hypertensive disorders of pregnancy and normal pregnant women.

Methods: 50 women affected by hypertensive disorders of pregnancy and 50 normal pregnant women more than 20 weeks of gestation, admitted to the ward or to labour room in the Obstetrics and Gynaecology Department, of Mahatma Gandhi Medical College and Hospital were enrolled in the study. Assessment of serum 25 hydroxy vitamin D was done by chemiluminescent immunoassay method.

Results: Serum vitamin D levels were low in women with hypertensive disorders of pregnancy with mean serum vitamin D level 13.66±7.358 ng/ml as compared to normal normotensive pregnant women 21.14±8.241ng/ml, which is statistically significant (p=0.001). Mean vitamin D level in study population was 17.40±8.634 ng/ml. The prevalence of vitamin D deficiency in hypertensive disorders of pregnancy group was very high 88% compared to 50% in normal normotensive pregnant women group. The difference was statistically significant (p=0.001). vitamin D deficiency was found among 69% in study population.  

Conclusions: Vitamin D levels are deficient in patients of hypertensive disorders of pregnancy as compared to normal pregnant women. There is increased prevalence of vitamin D deficiency with hypertensive disorders of pregnancy suggesting that vitamin D deficiency can be a risk factor for the development of hypertensive disorders of pregnancy.


Hypertensive disorders of pregnancy, Gestational hypertension, Pre-eclampsia, Eclampsia, Vitamin D

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Roberts JM, Hubel CA. The two-stage model of preeclampsia: variations on the theme. Placen. 2009;30:S32-7.

Kashyap MK, Saxena SV, Khullar M, Sawhney H, Vasishta K. Role of anion gap and different electrolytes in hypertension during pregnancy (preeclampsia). Mol Cell Biochem. 2006;282:157-67.

Atamer Y, Koçyigit Y, Yokus B, Atamer A, Erden AC. Lipid peroxidation, antioxidant defense, status of trace metals and leptin levels in preeclampsia. Eur J Obstet Gynecol Reprod Biol. 2005;119:60-6.

Wei S, Audibert F, Hidiroglou N, Sarafin K, Julien P, Wu Y, et al. Longitudinal vitamin D status in pregnancy and the risk of pre-eclampsia. Brit J Obstet Gynaecol. 2012;119:832-9.

Fischer D, Schroer A, Ludders D, Cordes T, Bücker B, Reichrath J, et al. Metabolism of vitamin D3 in the placental tissue of normal and preeclampsia complicated pregnancies and premature births. Clin Exp Obstet Gynecol. 2007;34:80-4.

Michael F. Holick Neil C. Binkley Heike A. Bischoff-Ferrari Catherine M. GordonDavid A. Hanley Robert P. Heaney M. Hassan Murad Connie M. Weaver, “Evaluation, Treatment, and Prevention of Vitamin D Deficiency: an Endocrine Society Clinical Practice Guideline”. J Clinic Endocrinol Metabol. 2011;96(7):1911-30.

Mulligan ML, Felton SK, Riek AE, Bernal-Mizrachi C. Implications of vitamin D deficiency in preg-nancy and lactation. Am J Obstet Gynecol. 2010;202:429.

Shin JS, Choi MY, Longtine MS, Nelson DM. Vit-amin D effects on pregnancy and the placenta. Pla-centa. 2010;31:1027-34.

Mehmood S, Karim SA. Vitamin D deficiency during pregnancy and its relationship with pre-eclampsia, eclampsia and gestational hypertension. Austin J Nutr Metab. 2016;3(2):1040.

Bakacak M, Serin S, Ercan O, Köstü B, Avci F, Kılınç M, et al. Comparison of Vitamin D levels in cases with preeclampsia, eclampsia and healthy pregnant women. Int J Clinic Experiment Medic. 2015;8(9):16280.

Tabesh M, Salehi-Abargouei A, Tabesh M, Esmaill-zadeh A. Maternal vitamin D status and risk of pre-eclampsia: a systematic review and meta-analysis. J Clin Endocrinol Metab. 2013;98:3165-73.

Aghajafari F, Nagulesapillai T, Ronksley PE, Tough SC, O'Beirne M, Rabi DM. Association between maternal serum 25-hydroxyvitamin D level and pregnancy and neonatal outcomes. Systematic re-view and meta-analysis of observational studies. Brit Med J. 2013;346:f1169.

Sadin B, Pourghassem Gargari B, Pourteymour Fard Tabrizi F. Vitamin D status in preeclamptic and non-preeclamptic pregnant women: a case-control study in the North West of Iran. Heal Promot Perspect. 2015;5(3):183-90.

Umar N, Tauseef A, Shahzad F, Sabir S, Kanwal S, Akmal A et al. Serum 25- Hydroxy Vitamin D level in preeclamptic and normotensive pregnancies. J Coll Physic Surg Pak. 2016;26(8):673-6.

Bodnar LM, Catov JM, Simhan HN, Holick MF, Powers RW, Roberts JM. Maternal vitamin D deficiency increases the risk of preeclampsia. J Clin Endocrinol Metab. 2007;92:3517-22.

Ullah MI, Koch CA, Tamanna S, Rouf S, Shamsuddin L. Vitamin D deficiency and the risk of preeclampsia and eclampsia in Bangladesh. Horm Metab Res. 2013;45:682-7.

Goel P, Garg G, Kaur J, Mehra R, Tandon R, Huria A. Association of vitamin D deficiency during pregnancy with preeclampsia and eclampsia. Int J Reprod Contracept Obstet Gynecol. 2016;5(9):3046-50.