Type 2 diabetes mellitus in glucose-6-phosphate dehydrogenase deficient individuals in a Ghanaian population

Perez Quartey; Bright Afriyie Owusu; Daniel Taylor; Eliza-Bertha Adomaka

doi:10.18203/2320-6012.ijrms20205303

Authors

Perez Quartey Department of Medical Laboratory Technology, Garden City University College, Kenyase, Ghana
Bright Afriyie Owusu Department of Medical Laboratory Technology, Garden City University College, Kenyase, Ghana
Daniel Taylor Department of Medical Laboratory Technology, Garden City University College, Kenyase, Ghana
Eliza-Bertha Adomaka Department of Medical Laboratory Technology, Garden City University College, Kenyase, Ghana

DOI:

https://doi.org/10.18203/2320-6012.ijrms20205303

Keywords:

G6PD deficiency, Ghanaians adults, Type 2 diabetes mellitus

Abstract

Background: Studies in different populations have shown an association between diabetes mellitus and G6PD deficiency. This association has not been investigated in the Ghanaian population. We conducted a cross-sectional study to investigate the relationship between G6PD deficiency and type 2 diabetes mellitus in a Ghanaian population.

Methods: The cross-sectional study involved 125 registered type 2 diabetes mellitus clients and 125 non-diabetic individuals. Chi-square analysis was used to assess the association between G6PD status and type 2 diabetes mellitus with statistical significance pegged at p-value<0.05.

Results: The prevalence of G6PD deficiency in the study population was 24.0% and 13.6% for the diabetics and non-diabetics respectively. In terms of gender, 29.5% of the diabetic males were G6PD deficient whiles G6PD deficiency was observed in 11.1% of the non-diabetic males. Additionally, 21.0% of the diabetic females were also G6PD deficient with 15.3% of the non-diabetic females being G6PD deficient. The results showed that the overall G6PD deficiency was significantly associated with type 2 diabetes mellitus as compared to the non-diabetics. In terms of gender differences, G6PD deficiency was significantly associated with type 2 diabetes in males but, there was no significant association in females.

Conclusions: The study reports the first findings of the relationship between G6PD deficiencies among type 2 diabetes patients in Ghana. The study revealed that G6PD deficiency is more prevalent among type 2 diabetics than non-diabetics. Type 2 diabetes mellitus is independently associated with G6PD deficiency in males but not females.

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References

Kletzien RF, Harris PK, Foellmi LA. Glucose-6-phosphate dehydrogenase: a “housekeeping” enzyme subject to tissue-specific regulation by hormones, nutrients, and oxidant stress. FASEB J. 1994;8:174-81.

Luzzatto L, Nannelli C, Notaro R. Glucose-6-Phosphate Dehydrogenase Deficiency. Hematol Oncol Clin North Am. 2016;30:373-93.

Nkhoma ET, Poole C, Vannappagari V, Hall SA, Beutler E. The global prevalence of glucose-6-phosphate dehydrogenase deficiency: a systematic review and meta-analysis. Blood Cells Mol Dis. 2009;42:267-78.

WHO Working Group. Glucose-6-phosphate dehydrogenase deficiency. Bull World Health Organ 1989;67:601-11.

Engwa GA, Nwalo FN, Chibuzor GE, Ejiagha EC, Abonyi MC, Ugwu TE, et al. Relationship between Type 2 Diabetes and Glucose-6Phosphate Dehydrogenase (G6PD) Deficiency and Their Effect on Oxidative Stress. J Diabetes Metab. 2018;9:800.

Gaskin RS, Estwick D, Pedi R. G6PD deficiency: its role in the high prevalence of diabetes mellitus. Ethn Dis. 2001;11:749-54.

Lai YK, Lai NM, Lee SWH. Glucose-6-phosphate dehydrogenase deficiency and risk of diabetes: a systematic review and meta-analysis. Annals Hematol. 2017;(96):839–45.

Santana MS, Monteiro WM, Costa MRF, Sampaio VS, Brito MAM, Marcus VG, et al. High Frequency of Diabetes and Impaired Fasting Glucose in Patients with Glucose-6-Phosphate Dehydrogenase Deficiency in the Western Brazilian Amazon. Am J Trop Med Hyg. 2014;91(1):74–6.

Heymann AD, Cohen Y, Chodick G. Glucose-6-Phosphate Dehydrogenase Deficiency and Type 2 Diabetes. Diabetes Care. 2012;35(8):e58-8.

Centers for Disease Control and Prevention. National diabetes fact sheet: general information and national estimates on diabetes in the United States, 2003. Rev ed. Atlanta (GA): U.S. Department of Health and Human Services, Centers for Disease Control and Prevention; 2004.

Bishop DB, Zimmerman BR, Roesler JS. Diabetes. In: Brownson RC, Remington PL, Davis JR, editors. Chronic disease epidemiology and control. 2nd edition. Washington (DC): Am Pub Heal Asso. 1998:421-64.

Lee ET, Welty TK, Cowan LD, Wang W, Rhoades DA, Devereux R, et al. Incidence of diabetes in American Indians of three geographic areas, the Strong Heart study. Diabetes Care. 2002;25(1):49-54.

Matsuda A, Kuzuya T. Relationship between obesity and concordance rate for type 2 (non-insulin-dependent) diabetes mellitus among twins. Diabetes Res Clin Pract 1994;26:137-43.

Busch CP, Hegele RA. Genetic determinants of type 2 diabetes mellitus. Clin Genet. 2001;60:243-54.

Klupa T, Malecki MT, Pezzolesi M, Ji L, Curtis S, Langefeld CD, et al. Further evidence for a susceptibility locus for type 2 diabetes on chromosome 20q13.1-q13.2. Diabetes 2000;49:2212-6.

Pes GM, Parodi G, Dore MP. Glucose-6-phosphate dehydrogenase deficiency and risk of cardiovascular disease: A propensity score-matched study. Atherosclerosis. 2019;282:148-53.