Susceptibility of blood group ABO and Rh for COVID-19

Sonu Suman


Background: The ABO and Rh blood group systems are part of the innate immune system and it has been shown that individuals with different ABO and Rh blood groups differ in their susceptibility or resistance to viral and bacterial infections and diseases. With the discovery of blood groups and subsequent great advancement in its study, many workers have tried to find out a possible relationship between the incidence of these blood groups and the incidence of various diseases. Aim of the study was determine the association between COVID-19 virus infection and blood groups.

Methods: This retrospective Case- control observational study was performed among subjects reported to hospital situated at central India for RT PCR-COVID-19 sampling during the period between March to September 2020. Total subjects enrolled were 1682.

Results: The individuals with blood group Rh factor positive are found to be more susceptible in acquiring COVID-19 disease. Likelihood of getting COVID-19 is more with factor Rh positive in comparison to Rh negative counterparts. The association is observed statistically between Rh factor and status of COVID-19.

Conclusions: In conclusion our results implicate that blood group are found to be associated with the status of COVID-19 disease. It is observed that the Rh positive individuals are more susceptible when compared to their Rh negative counterparts in acquiring COVID-19 disease.


Blood group, COVID-19, Disease association

Full Text:



Richman DD, Whitley RJ, Hayden FG. Clinical Virology, 4th ed. Washington: ASM Press; 2016.

Rothe C, Schunk M, Sothmann P, Bretzel G, Froeschl G, Wallrauch, et al. Transmission of 2019-nCoV infection from an asymptomatic contact in Germany. N Engl J Med. 2020;382(10):970-1.

Sayal SK, Das AL, Nema SK. Study of blood groups in HIV seropositive patients. Ind J Derm Ven Lepr. 1996;62(5):295-7.

Greenwell P. Blood group antigens: Molecules seeking a function? Glycoconj J. 1997;14:159-73.

Skripal IG. ABO system of blood groups in people and their resistance to certain infectious diseases (prognosis). Mikrobiol Z. 1996;58:102-8.

Kaipainen WJ, Vuorinen YV. ABO blood groups in pernicious anaemia and pernicious tapeworm anaemia. Ann Med Exp Biol Fenn. 1960;38:212-3.

Roberts F. Blood groups and susceptibility to disease: a review. Br J Prev Soc Med. 1957;11:107–25.

Qiang Li CY, Jin-Hong Y, Li Liu, Shuang-Shuang X, Wen-Wen L, Xia Y, et al. ABO blood group and the risk of hepatocellular carcinoma: a case-control study in patients with chronic hepatitis B. PLoS One. 2012;7(1):e29928.

Alo MN, Eze UA, Yaro SA, Jubril B, Nwanoke NN. Relationship between ABO and Rhesus blood groups and susceptibility to asthma within Sokoto Metropolis, Nigeria. Int J Immunol. 2015;3(3):37-41.

Garratty G. Relationship of blood groups to disease: do blood group antigens have a biological role? Rev Med Inst Mex Seguro Soc. 2005;43(S1):113-21.

Behal R, Jain R, Behal KK, Dhole TN. Variation in the host ABO blood group may be associated with susceptibility to hepatitis C virus infection. Epidemiol Infect. 2010;138(8):1096-9.