Screening for hemoglobinopathies in a socially disadvantaged population from a rural district of West Bengal, India

Authors

  • Prakas Kumar Mandal Department of Hematology, NRS Medical College, Kolkata, West Bengal, India
  • Tuphan Kanti Dolai Department of Hematology, NRS Medical College, Kolkata, West Bengal, India
  • Soma Mandal School of Nursing, R. G. Kar Medical College and Hospital, Kolkata, West Bengal, India
  • Tamanash Mondal Department of Molecular Biology, Maulana Abul Kalam Azad University of Technology (MAKAUT), Kalyani, West Bengal, India
  • Suman Kumar Maji Department of Microbiology, Purulia Government Medical College and Hospital, Purulia, West Bengal, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20205319

Keywords:

West Bengal, Jhargram district, Socially challenged population, Thalassemia screening

Abstract

Background: Detection of traits/carriers plays an important role in preventing the birth of a thalassemic child. West Bengal, one of the eastern states in India is the home to a bulk of socially challenged population including scheduled castes and scheduled tribes among others. The present study aimed to detect the prevalence of different hemoglobinopathies in a socially challenged district of West Bengal.

Methods: In this retrospective cross sectional study thalassemia detection camps were organized at the community level over a period of four years. Venous blood samples were subjected to complete hemogram and high performance liquid chromatography (HPLC). In few difficult cases samples were sent to the reference laboratory for molecular characterization. The prevalence of heterozygous, homozygous or compound heterozygous states of different thalassemias and hemoglobinopathies across various respondent groups (e.g. children, premarital, postmarital and antenatal) and existing caste categories (scheduled tribes, scheduled caste and general) were analyzed.

Results: We analyzed a total of 114,606 HPLC reports; 18681 (16.30%), 15438 (13.47%) and 80487 (70.23%) cases belonged to scheduled tribes, scheduled castes and general category respectively. Out of 114,606 cases, 11,001 (9.6%) had revealed abnormal hemoglobins; beta thalassaemia trait was the most common (6.63%; n=7602) across all subgroup analysis. Among others, HbE trait, sickle cell trait and HbD trait were detected in 1788 (1.56%), 1362 (1.18%) and 126 (0.11%) cases respectively.

Conclusions: Beta thalassaemia trait and HbE trait are the common haemoglobin variants in this rural district of West Bengal. The prevalence of sickle gene revealed in the present study is much less than previous studies in the locality.

References

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Published

2020-11-27

How to Cite

Mandal, P. K., Dolai, T. K., Mandal, S., Mondal, T., & Maji, S. K. (2020). Screening for hemoglobinopathies in a socially disadvantaged population from a rural district of West Bengal, India. International Journal of Research in Medical Sciences, 8(12), 4430–4435. https://doi.org/10.18203/2320-6012.ijrms20205319

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Original Research Articles