Evaluation of serum ferritin as a prognostic marker in acute ischemic stroke: a prospective observational study
Keywords:Ferritin, Prognostic marker, Acute ischemic stroke, Prognostic factor, Brain ischemia
Background: Stroke is an important health problem causing of morbidity and mortality globally. Serum ferritin has gained clinical significance as a prognostic factor that can aggravate the cytotoxicity of brain ischemia. The present study investigated the prognostic significance of serum ferritin levels with the severity of stroke using NIHSS scale.
Methods: It was a prospective observational study conducted on 60 patients with acute ischemic stroke admitted in the general medicine department of a tertiary care teaching hospital. Serum ferritin levels were assessed on all participants using the instrument “immulite”. National institute of health stroke scale scoring was applied at the time of admission and on the seventh day to assess the impairment caused by a stroke. IBM SPSS version 22 was used for statistical analysis.
Results: The mean serum ferritin levels at admission in patients with severe stroke, moderate stroke and mild and less stroke were 337.41±58.76, 285.56±49.37, and 197.91±111.01 ng/mL, respectively. The mean serum ferritin levels at admission were 178.76±114.70 ng/mL and 341.91±62.292 ng/mL in subjects who did not deteriorate and those who deteriorated, respectively. Whereas the mean serum ferritin levels on the sixth day were 198.34±106.88 and 348.10±57.34 ng/mL in subjects who did not deteriorate and those who deteriorated, respectively.
Conclusions: Serum ferritin has a significant positive correlation with the severity of acute ischemic stroke severity on admission (p<0.001) and negative correlation with the severity of acute ischemic stroke severity on seventh day of admission (p<0.001). Thus, serum ferritin can be used as a prognostic marker in acute ischemic stroke.
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