Clinicopathological study of patients with pancytopenia
DOI:
https://doi.org/10.18203/2320-6012.ijrms20205837Keywords:
Pancytopenia, Megaloblastic anemia, Pallar, HemoglobinAbstract
Background: Pancytopenia is due to bone marrow failure characterized by anemia, leukopenia, and thrombocytopenia. It a common hematological disorder. Low blood counts in the bone marrow failure disease result from deficient hematopoiesis. Marrow damage and dysfunction also may be secondary to infection, inflammation, or cancer. Pancytopenia has an extensive differential diagnosis and it can result from damage to bone marrow destruction of preformed blood cells peripherally with increased reticulocyte count. Aim of the study were to study the different etiological conditions and clinical features of pancytopenia in rural medical college.
Methods: This study has been conducted in the department of general medicine in association with the pathology department and between March 2019 to February 2020, 45 patients were included in this study. males were 27 and females were 18. The age group is between 20 years and 60 years. 2 ml of anticoagulant blood send for HB% total count, platelet count, packed cell volume, and RBC indices.
Results: The total no. of patients included in this study were 45 among these 45 patients, males were 27, and females were 18. The common age group is between 20 and 60 years and the common causes of aplastic anemia in our study are megaloblastic anemia.
Conclusions: Pancytopenia is a common hematological problem in India. In our study megaloblastic anemia is the most common cause of pancytopenia females are affected during pregnancy. So, periodical clinically examined and investigations may reduce the incidence. of further research with a large sample size and meticulous investigations required to replicate the finding of the study.
References
Mohler DN, Leavell BS. Aplastic anemia an analysis of 50 cases. Ann Int Med. 1958:49:326-62.
Lec FS, Percy. The MF pathology and erythrocytosis. Ann Rev Pathol. 6:165:2011.
Al Khalisi, Rhaima AS. Pancytopenia in adult patients at Baghdad teaching hospital. Iraq postgrad med j. 2011;10:441-8.
Rauff B, Idrees M, Shah SA, Butt S, Butt AM, Ali L et al. Hepatitis associated aplastic anemia a review. Virol J. 2011;8:87-92.
Raja S, Suman FR, Scott JX, Latha MS, Rajenderan A, Ethican A. Pancytopenia: An obstacle in the diagnosis of the outcome of pediatric all. South Asian j can. 2015;4(2):68-71.
Karma R, Kalesa SP, Anand A, Madan M. Pancytopenia-A six years study. JAPI. 2001;49;1079-84.
Tasiq M, Khan N, Basri R, Amin S. Etiology of pancytopenia. Prof med J. 2010;17:814.
Mussarath N, Fayal R, Mohamad TK. Clinical and hematological features of megaloblastic anemia alone or in combined with is the deficiency of anemia. An analysis of 349 patients. J Med Sci. 2009;17:81-4.
Klunger JM, Sharma Ranga S, Tahb VH. Pancytopenia-A clinical hematological study of 200 cases. Indies J Pathol microbiome. 2002;45:375-9.
Papadakis MA, McPhee SJ, Rabow MW. Current medical diagnosis and treatment in ch. 13, McGraw-Hill Education/Medical; 55th edition. 2016;510-13.
Tilak V, Jain R. Pancytopenia A clinical hematological analysis of 77 cases. Indian J pantho Microbiol. 1999;42:399-404.
Swamy RM, Nandini P. Bone marrow examination in pancytopenia. J Med Asso. 2012;110;560-2-566.
Khanduri U, Sharma A. Megaloblastic Anemia: prevalence and causative factors: nati. Med J India. 2007;20:172-5.
Sayami G, Adhikari RC. Bone marrow examination in case of pancytopenia JNMA. J Nepal Med Asso. 2008;47-12-7.
