Study of analgesic property of diacerein in rat

Rajlaxmi Upadhyay; Goutam Siddhartha; Manas Ranjan Upadhyay; Trupti Rekha Swain

doi:10.18203/2320-6012.ijrms20205011

Authors

Rajlaxmi Upadhyay Department of Pharmacology, SCB Medical College, Cuttack, Odisha
Goutam Siddhartha Department of Pharmacology, SCB Medical College, Cuttack, Odisha
Manas Ranjan Upadhyay Department of Paediatrics, FM Medical College, Balasore, Odisha
Trupti Rekha Swain SLN Medical College, Koraput, Odisha

DOI:

https://doi.org/10.18203/2320-6012.ijrms20205011

Keywords:

Diacerein, Analgesia, Tail-flick-latency

Abstract

Background: Diacerein has been known as an anti-osteoarthritic agent that is usually given along with other analgesic drugs. Still there is no evidence of the analgesic effect of diacerein alone. So this pilot study was undertaken to assess the analgesic property at supra-spinal level by using the tail-flick method.

Methods: Diacerein at doses of 50, 100 and 200 mg/kg was given to Albino wistar rats weighing approximately 100-200 grams along with distilled water as placebo. All drugs were given by oral routes and the analgesic effect was evaluated using analgesiometer at baseline, 15 min, 30 min, 60 min and 120 min. Analgesic activity was measured as change in tail flick latency from baseline in animals.

Results: Diacerein showed significant increase in tail flick latency and showed promising analgesic activity compared to placebo starting from 15 mins till 60 mins. However the effect persisted up to one hour only and after which it started decreasing.

Conclusions: Diacerein at all the three doses possess dose dependant analgesic activity that is maximally effective up to 60 minutes.

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Author Biographies

Rajlaxmi Upadhyay, Department of Pharmacology, SCB Medical College, Cuttack, Odisha

Assistant Professor, Department of Pharmacology, S.C.B Medical College, Cuttack, Odisha, India

Goutam Siddhartha, Department of Pharmacology, SCB Medical College, Cuttack, Odisha

Senior Resident, Dept of Pharmacology, S.C.B.Medical College, Cuttack, Odisha, India

Manas Ranjan Upadhyay, Department of Paediatrics, FM Medical College, Balasore, Odisha

Associate Professor, Dept. of Pediatrics, FM Medical College, Balasore, Odisha, India

Trupti Rekha Swain, SLN Medical College, Koraput, Odisha

Professor and Head,Department of Pharmacology, S.L.N Medical College, Koraput, Odisha, India

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