Study of blood donor complications after whole blood donation in our center
Keywords:Blood donors, VVRs, Hematoma, Arterial puncture
Background: Despite the advent of many synthetic and semi-synthetic products, the importance of biological blood products cannot be undermined in the current era. The blood donors are the backbone of any health care delivery system that has a well-organized blood transfusion service.
Methods: A prospective study conducted for the period of 16 months aimed to find out various complications and their frequencies before, during or after the blood donations. The donors who developed any complications were followed up for at least three weeks to assess the late reactions if any. Blood donation was carried out with proper precautions and asepsis by experienced phlebotomists.
Results: Out of 10346 blood donations, 9887 were from replacement donors, while 459 were from voluntary donors. Total donation associated complications were 113, out of which the majority were VVRs (n=74), followed by venous hematomas (n=34) and arterial punctures (n=5). Of the 74 donors who had a VVR after blood donation, the incidence was higher in females (1.64% versus 0.69%). A higher incidence of VVRs was seen among the donors who had a history of previous blood donation.
Conclusions: This study strengthened the fact that though blood donation is relatively safe, it still has a complication rate of nearly 1%. To encourage for blood donation at a regular interval, all the possible steps should be taken to minimize the rate of complications. More medical attention should be given to the “at-risk” donors.
Sarkar S. Indian J Crit Care Med. 2008;12(3).
M.S. TJ. Complications Associated with Blood Donations in a Blood Bank at an Indian Tertiary Care Hospital. JCDR. 2014.
Weymouth W, Long B, Koyfman A, Winckler C. Whole Blood in Trauma: A Review for Emergency Clinicians. The Journal of Emergency Medicine. 2019;56:491-8.
Blood safety and availability. Who.int. https://www.who.int/news-room/fact-sheets/detail/blood-safety-and-availability. Accessed on 20 November 2020.
Newman BH, Waxman DA. Blood donation-related neurologic needle injury: evaluation of 2 years' worth of data from a large blood center. Transfusion 1996;36:213-5.
Eder AF, Dy BA, Kennedy JM. The American Red Cross donor hemovigilance program: complications of blood donation reported in 2006. Transfusion. 2008;48:1809-19.
Benjamin RJ, Dy BA, Kennedy JM. The relative safety of automated two-unit red blood cell procedures and manual whole-blood collection in young donors. Transfusion. 2009;49:1874-83.
France CR, Rader A, Carlson B. Donors who react may not come back: analysis of repeat donation as a function of phlebotomist ratings of vasovagal reactions. Transfus Apher Sci. 2005;33:99-106.
Newman BH. Vasovagal reactions in high school students: findings relative to race, risk factor synergism, female sex, and non-high school participants. Transfusion. 2002;42:1557-560.
Tondon R, Pandey P, Chaudhary R. Vasovagal reactions in ‘at risk’ donors: a univariate analysis of effect of age and weight on the grade of donor reactions. Transfus Apher Sci. 2008;39:95-99.
Crocco I, Franchini M, Garozzo G, Gandini AR, Gandini G, Bonomo P, et al. Adverse reactions in blood and apheresis donors: experience from two Italian transfusion centres. Blood Transfus. 2009;7:35-38.
Majlessi F, Ghafari S, Rahimi-Foroushani A, Maghsoodlou M. Systemic complications and their risk factors among Tehranian blood donor, 2005. Acta Medica Iranica. 2008;46:253-57.
Zervou EK, Ziciadis K, Karabini F, Xanthi E, Chrisostomou E, Tzolou A. Vasovagal reactions in blood donors during or immediately after blood donation. Transfus Med. 2005;15:389-94.
Sorensen BS, Johnsen SP, Jorgensen J. Complications related to blood donation: a population-based study. Vox Sang. 2008;94:132-37.
Newman BH. Arterial puncture phlebotomy in whole-blood donors. Transfusion. 2001;41:1390-2.
Newman BH. Blood donor complications after whole-blood donation. Curr Opin Hematol. 2004;11:339-45.