Clinical outcome of muscle invasive carcinoma urinary bladder patients treated with bladder preservation protocol

John Joseph; Aswin Kumar; Susan Mathews; Jagathnath K. M. Krishna; Francis V. James

doi:10.18203/2320-6012.ijrms20205656

Authors

John Joseph Department of Radiation Oncology, Regional Cancer Centre Trivandrum, Thiruvananthapuram, Kerala, India http://orcid.org/0000-0001-6424-2613
Aswin Kumar Department of Radiation Oncology, Regional Cancer Centre Trivandrum, Thiruvananthapuram, Kerala, India
Susan Mathews Department of Radiation Oncology, Regional Cancer Centre Trivandrum, Thiruvananthapuram, Kerala, India
Jagathnath K. M. Krishna Department of Cancer Epidemiology and Biostatistics, Regional Cancer Centre Trivandrum, Thiruvananthapuram, Kerala, India
Francis V. James Department of Radiation Oncology, Regional Cancer Centre Trivandrum, Thiruvananthapuram, Kerala, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20205656

Keywords:

Muscle invasive bladder cancer, Bladder preservation, Radiotherapy

Abstract

Background: To evaluate the outcome in terms of bladder preservation in muscle invasive urinary bladder patients treated with radical radiotherapy.

Methods: A total of sixty patients with muscle invasive bladder cancer who were treated between 2011 and 2013 with bladder preservation protocol were identified. Thirty-two patients were stage T2 disease, rest were T3 and T4. Initial TURBT was reported complete in 24 of the total 60 patients. All patients received 60 to 64Gy to the whole bladder.

Results: The follow-up range was 3 to 72 months. One year follow-up proportion was 78%. The median progression free survival was 40months. Early stage (T2) and advanced stage (T3 and T4) had progression free survival of 87.8% and 48.5% respectively at one year follow-up with a p value of 0.001. Thirty-six patients who had an incomplete Transurethral resection of bladder tumor (TURBT) initially had a statistically significant lower PFS compared to those patients who had a complete TURBT with a p value of 0.029. Twenty-nine patients were disease free with an intact bladder during the follow-up period providing a bladder preservation rate of 48%.

Conclusions: A bladder-conserving protocol with radiotherapy provides encouraging results with nearly half of the patients able to retain a disease-free bladder. Proper patient selection with early stage disease and those with complete TURBT may further improve the bladder preservation rates.

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References

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