Study of coronary artery disease in young population of Central India


  • Vikas A. Mishra Department of Cardiology, Superspeciality Hospital, NSCB Medical College, Jabalpur, Madhya Pradesh
  • Amit B. Kinare Department of Cardiology, Superspeciality Hospital, NSCB Medical College, Jabalpur, Madhya Pradesh
  • Jayanta Pal IQ City Medical College, Durgapur, West Bengal
  • Vishwa Deepak Tripathi Department of Cardiology, Superspeciality Hospital, SS Medical College, Rewa, Madhya Pradesh
  • Ravi Shankar Sharma Department of Cardiology, Superspeciality Hospital, NSCB Medical College, Jabalpur, Madhya Pradesh
  • Pradeep Kumar Jain Department of Cardiology, Superspeciality Hospital, NSCB Medical College, Jabalpur, Madhya Pradesh



Coronary artery disease, Indian population, Obstructive and non-obstructive coronary artery disease, Coronary microvascular disease


Background: Coronary heart disease is the most common indication among cardiovascular diseases (CVD) and a major cause of mortality and morbidity. According to global burden of disease study estimates, nearly 24.8% of all deaths in India are attributable to CVD. Objectives of the current research study were to establish a correlation between varied risk factors and coronary artery disease (CAD), to determine angiographic characteristics individually in patients with multiple risk factors and to evaluate number of vessels involved in CAD.

Methods: Present study was a prospective study conducted on 50 patients with acute coronary syndrome below 40 yrs of age admitted at the department of cardiology, Superspeciality hospital, NSCB medical college, Jabalpur. All patients included in the study were subjected to coronary angiography. The angiographic characteristics such as extent of CAD (characterized by the number of vessels with angiographic lesions) were determined.

Results: Current study findings depicted that most of CAD patients were in age group of 36-40 years. Proportion of males was higher than females. One-fifth of patients were diabetics and 34.0% were hypertensive. It was observed that 54.0% CAD patients had history of smoking and 32.0% had history of premature CAD. Most of patients exhibited single vessel disease in CAG and left anterior descending (LAD) was the most commonly involved artery.

Conclusions: Smoking was concluded as one of the major risk factor associated with CAD and most of patients exhibited single vessel disease, LAD being the most commonly involved artery. Significant number of patients with family history depicted high risk for CAD. Males were concluded to be more prone to CAD at younger age.


Mahmood SS, Levy D, Vasan RS, Wang TJ. The Framingham heart study and the epidemiology of cardiovascular disease: A historical perspective. Lancet. 2014;383:999-1008.

Allen J, Szanton S. Gender, ethnicity, and cardiovascular disease. J Cardiovasc Nurs. 2005;20(1):1-6.

Coronary heart disease. Available at: Accessed on 20 July 2020.

Hajar R. Risk Factors for Coronary Artery Disease: Historical Perspectives. Heart Views. 2017;18(3):109-14.

Anand SS, Yusuf S, Vuksan V, Devanesen S, Teo KK, Montague PA, et al. Differences in risk factors, atherosclerosis, and cardiovascular disease between ethnic groups in Canada: The Study of health assessment and risk in ethnic groups (SHARE). Lancet. 2000;356(9226):279-84.

Kandaswamy E, Zuo L. Recent Advances in Treatment of Coronary Artery Disease: Role of Science and Technology. Int J Mol Sci. 2018;19(2):424.

Anand SS, Islam S, Rosengren A, Franzosi MG, Steyn K, Yusufali AH, Keltai M, Diaz R, Rangarajan S, Yusuf S. Risk factors for myocardial infarction in women and men: Insights from the INTERHEART study. Eur Heart J. 2008;29(7):932-40.

Asia Pacific cohort studies collaboration. The effects of diabetes on the risks of major cardiovascular diseases and death in the Asia Pacific region. Diabetes Care. 2003;26(2):360-6.

Yusuf S, Rangarajan S, Teo K, Islam S, Li W, Liu L, et al. Cardiovascular risk and events in 17 low-, middle-, and high-income countries. N Engl J Med. 2014;371:818-27.

GBD 2013 mortality and causes of death certificates. global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the global burden of disease study 2013. Lancet. 2015;385:117-71.

Xavier D, Pais P, Devereaux PJ, Xie C, Prabhakaran D, Reddy KS, et al. Treatment and outcomes of acute coronary syndromes in India (CREATE): a prospective analysis of registry data. Lancet. 2008;371:1435-42.

Patel V, Chatterji S, Chisholm D, Ebrahim S, Gopalakrishna G, Mathers C, et al. Chronic diseases and injuries in India. Lancet. 2011;377:413-28.

Soman CR, Kutty VR, Safraj S, Vijayakumar K, Rajamohanan K, Ajayan K, et al. All-cause mortality and cardiovascular mortality in Kerala state of India: results from a 5-year follow-up of 161,942 rural community dwelling adults. Asia Pac J Public Health. 2011;23:896-903.

Huffman MD, Prabhakaran D, Osmond C, et al. Incidence of cardiovascular risk factors in an Indian urban cohort results from the New Delhi birth cohort. J Am Coll Cardiol. 2011;57(17):1765-74.

Gupta R, Joshi P, Mohan V, Reddy KS, Yusuf S. Epidemiology and causation of coronary heart disease and stroke in India. Heart. 2008;94:16-26.

Bodkhe S, Jajoo SU, Jajoo UN, Ingle S, Gupta SS, Taksande BA. Epidemiology of confirmed coronary heart disease among population older than 60 years in rural central India-A community-based cross-sectional study. Indian Heart J. 2019;71(1):39-44.

Goyal A, Yusuf S. The burden of cardiovascular disease in the Indian subcontinent. Indian J Med Res. 2006;124(3):235-44.

Ahmad N, Bhopal R. Is coronary heart disease rising in India? A systematic review based on ECG defined coronary heart disease. Heart. 2005;91(6):719-25.

Yusuf S, Hawken S, Ounpuu S, Dans T, Avezum A, Lanas F, et al. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries: case-control study. Lancet. 2004;364(9438):937-52.

Krishnaswami S, Prasad NK, Jose VJ. A study of lipid levels in Indian patients with coronary arterial disease. Int J Cardiol. 1989;24(3):337-45.

Sharma SN, Kaul U, Sharma S, Wasir HS, Manchanda SC, Bahl VK, et al. Coronary arteriographic profile in young and old Indian patients with ischaemic heart disease: a comparative study. Indian Heart J. 1990;42(5):365-9.

Matheus AS, Tannus LR, Cobas RA, Palma CC, Negrato CA, Gomes MB. Impact of diabetes on cardiovascular disease: an update. Int J Hypertens. 2013;2013:653789.

Leon BM, Maddox TM. Diabetes and cardiovascular disease: Epidemiology, biological mechanisms, treatment recommendations and future research. World J Diabetes. 2015;6(13):1246-58.

Rivellese AA, Riccardi G, Vaccaro O. Cardiovascular risk in women with diabetes. Nutr Metab Cardiovasc Dis. 2010;20:474-80.

Zimmerman FH, Cameron A, Fisher LD, Ng G. Myocardial infarction in young adults: angiographic characterization, risk factors and prognosis. J Am Coll Cardiol. 1995;26(3):654-61.




How to Cite

Mishra, V. A., Kinare, A. B., Pal, J., Tripathi, V. D., Sharma, R. S., & Jain, P. K. (2020). Study of coronary artery disease in young population of Central India. International Journal of Research in Medical Sciences, 9(1), 73–78.



Original Research Articles