Chapare mammarenavirus - a new deadly virus outbreak: a review

Authors

  • Dnyaneshwari Gujar Department of Periodontology, Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Pune, Maharashtra, India
  • N. Sriram Choudary Deptartment of Dentistry, Dhanalakshmi Srinivasan Medical College and Hospital, Perambalur, Chennai, Trichy national highway, Tamil Nadu, India
  • Chaitrali Joshi Department of Periodontology, Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Pune, Maharashtra, India
  • Nikhitha Raigir Intern, Bachelor of Dental Surgery, Sri Sai College of Dental Surgery, Vikarabad, Telangana, India
  • Shreshth Sharma Consultant Oral and Maxillofacial Surgeon, Bhopal, Madhya Pradesh, India
  • Kommuri Baji Babu Oral and Maxillofacial Surgery, Government Dental College and Hospital, Vijayawada, Andhra Pradesh, India
  • Rahul V. C. Tiwari 6Department of OMFS, Narsinbhai Patel Dental College and Hospital, Sankalchand Patel University, Visnagar, Gujarat, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20205657

Keywords:

Chapare virus, Mammarenavirus, New world epidemiology

Abstract

In 2003 an emerging mammarenavirus (formerly arenaviruses) was discovered in Bolivia and named Chapare (CHAPV). It was related to severe and fatal haemorrhagic fever, being similar in clinical features to Machupo (MACV). In mid-2019, CHAPV was the explanation for a cluster of 5 cases, two of them laboratory confirmed, three of them fatal. Reverse transcription polymerase chain reaction (RT-PCR) analysis and subsequent analysis of the entire virus S and L ribonucleic acid (RNA) segment sequences identified the virus as a member of the New World Clade B arenaviruses, which includes all the pathogenic South American arenaviruses. The virus was shown to be most closely associated with Sabia´ virus, but with 26% and 30% nucleotide difference within the S and L segments, and 26%, 28%, 15% and 22% aminoalkanoic acid differences for the L, Z, N, and GP proteins. LUJV, CHAPV, GTOV, and SABV, which are geographically restricted, have been associated with only a few to a few dozen cases. They are, therefore, relatively unimportant to clinicians compared to many other viruses that are usually co-endemic. However, MACV, JUNV, and especially LASV have caused large outbreaks (LASV has caused hundreds of thousands of infections per year). Visitors to countries in which these viruses are endemic, or war-fighters that are deployed to these countries, need to be aware of how to prevent and suspect a mammarenavirus infection.

Author Biographies

Dnyaneshwari Gujar, Department of Periodontology, Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Pune, Maharashtra, India

Associate professor, Department of periodontology, Dr.D.Y.Patil dental college and hospital, Dr.DY Patil Vidyapeeth Pune.

N. Sriram Choudary, Deptartment of Dentistry, Dhanalakshmi Srinivasan Medical College and Hospital, Perambalur, Chennai, Trichy national highway, Tamil Nadu, India

MDS-OMFS, Assistant Professor- Dept of Dentistry, Dhanalakshmi Srinivasan Medical College & Hospital, Perambalur, Chennai-Trichy national highway, Tamilnadu

Chaitrali Joshi, Department of Periodontology, Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Pune, Maharashtra, India

PG Student, Department of periodontology, Dr.D.Y.Patil dental college and hospital, Dr.DY Patil Vidyapeeth Pune

Nikhitha Raigir, Intern, Bachelor of Dental Surgery, Sri Sai College of Dental Surgery, Vikarabad, Telangana, India

Intern, Sri Sai College of Dental Surgery, Vikarabad.

Shreshth Sharma, Consultant Oral and Maxillofacial Surgeon, Bhopal, Madhya Pradesh, India

B.D.S, M.D.S, Consultant Oral and Maxillofacial Surgeon, Bhopal, Madhya Pradesh

Kommuri Baji Babu, Oral and Maxillofacial Surgery, Government Dental College and Hospital, Vijayawada, Andhra Pradesh, India

M.D.S, Oral and Maxillofacial Surgery, Government Dental College and Hospital, Vijayawada, Andhra Predesh

Rahul V. C. Tiwari, 6Department of OMFS, Narsinbhai Patel Dental College and Hospital, Sankalchand Patel University, Visnagar, Gujarat, India

OMFS, FOGS, PhD Scholar, Dept of OMFS, Narsinbhai Patel Dental College and Hospital, Sankalchand Patel University, Visnagar, Gujarat

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Published

2020-12-28

How to Cite

Gujar, D., Choudary, N. S., Joshi, C., Raigir, N., Sharma, S., Babu, K. B., & Tiwari, R. V. C. (2020). Chapare mammarenavirus - a new deadly virus outbreak: a review. International Journal of Research in Medical Sciences, 9(1), 300–302. https://doi.org/10.18203/2320-6012.ijrms20205657

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Section

Review Articles