Histopathological spectrum of salivary gland lesions - in a tertiary care centre

Gomathi Srinivasan, Francis Asir Joseph J., Shanmugam Kaliyaperumal, Arunalatha Ponnaiah




Background: Histopathology is the most important means in diagnosis of salivary gland lesions. The objective of this study is, to study occurrence of salivary lesions during a period of one year from January 2019 to December 2019, to study age, sex and site distribution of various salivary gland lesions, to study histo-morphological aspect of these lesions.

Methods: Surgically resected salivary gland specimens received at Department of Pathology, Government Stanley Medical College, Chennai were subjected to histopathological examination. Specimens were fixed in 10% neutral buffered formalin, processed, embedded, sections cut and stained with hematoxylin and eosin stain.

Results: There were a total of 30 salivary gland specimens. Out of thirty, 25 were neoplastic and 5 were non-neoplastic. Pleomorphic adenoma was the commonest of all benign tumors. Mucoepidermoid carcinoma was the most common malignant tumor. Among the 21 benign tumors, 16 cases of pleomorphic adenoma and a case each of myoepithelioma, benign metastasising pleomorphic adenoma, basal cell adenoma, warthins tumor and schwannoma were found. Among the 4 malignant tumors, 2 cases of mucoepidermoid carcinoma, a case of carcinoma ex pleomorphic adenoma and a case of myoepithelial carcinoma were found. Among the 5 non neoplastic lesions a case each of chronic sialadenitis, Sjogren’s syndrome, inflammatory myofibroblastioc tumor, parotid abscess and lymphoepithelial cyst were found.

Conclusions: The diagnosis of salivary gland lesions by histopathological examination is the most important method in diagnosis and differentiating benign and malignant lesions and to predict prognosis by typing, staging and grading of malignant neoplasms.


Salivary gland, Benign tumors, Malignant tumors

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Barnes L, Eveson JW, Reichart P. World Health Organization Classification of Tumours: Head and Neck Tumours. IARCPress, Lyon. 2005. Accessed on 09 November, 2020.

Cheuk W, John KC. Salivary gland tumors. In: Flecther C.D.M ed Diagnostic Histopathology of Tumors, 3rd ed. 2007;1.

Arey LB. Developmental Anatomy. WB Saunders, Philadelphia. 1974.

Dardick I, Thomas MJ, Van Nostrand AW. Myoepithelioma new concepts of histology and classification: A light and electron microscopic study. Ultrastruct Pathol. 1989;13:187-224.

Denny PC, Ball WD, Redman RS. Salivary glands: A paradigm for diversity of gland development. Crit Rev Oral Biol Med. 1997;8:51-75.

Kumar AA, Rakshitha HB, Alva NK, Reginald SR. Histopathological spectrum of salivary gland neoplasms in a tertiary care center. 2019;2(1):243-46.

Dandapat MC, Rath BK, Patnaik BK, Dash SN. Tumors of salivary glands. Indian J Surg. 1991;53:200.

Rewsuwan S, Settakorn J, Mahanupab P. Salivary gland tumors in Maharaj Nakorn Chiang Mai Hospital: a retrospective study of 198 cases. Chiang Mai Med Bull. 2006;45(2):45-3.

Joshi RR, Nepal A, Chettri ST, Bhattarai M, Ghimire A, Karki S. Primary salivary gland tumors in eastern Nepal tertiary care hospital. Journal of Nepal Health Research Council. 2010;8(1).

Ali NS, Nawaz A, Rajput S, Ikram M. Parotidectomy: a review of 112 patients treated at a teaching hospital in Pakistan. Asian Pacific journal of cancer prevention. APJCP. 2010;11(4):1111.

Moghadam SA, Moghadam FA, Dadfar M. Epithelial salivary gland tumors in Ahvaz, Southwest of Iran. Journal of dental research, dental clinics, dental prospects. 2010;4(4):120.

Vargas PA, Gerhard R, Araújo Filho VJ, Castro IV. Salivary gland tumors in a Brazilian population: a retrospective study of 124 cases. Revista do Hospital das Clinicas. 2002;57(6):271-6.

Fonseca FP, de Vasconcelos Carvalho M, de Almeida OP, Rangel AL, Takizawa MC, Bueno AG, Vargas PA. Clinicopathologic analysis of 493 cases of salivary gland tumors in a Southern Brazilian population. Oral surgery, oral medicine, oral pathology and oral radiology. 2012;114(2):230-9.

Venugopal M, Devi CP, Deepthi K, Mutte K. The dynamics of diagnosis of salivary gland tumours: histopathology matters. International Journal of Research in Medical Sciences. 2016;4(6):1855.

Ahrnad S, Lateef M, Ahmad R. Clinicopathological study of primary salivary-gland tumors in Kashmir. JK-practitioner. 2002;9(4):231-3.

Bashir S, Mustafa F, Malla HA, Khan AH, Rasool M, Sharma S. Histopathological spectrum of salivary gland tumors: A 10 year experience. Sch J App Med Sci. 2013;1(6):1070-4.

Shrestha S, Pandey GK, Pun CB, Bhatta R, Shahi R. Histopathological pattern of salivary gland tumors. Journal of Pathology of Nepal. 2014;4(7):520-4.

Richardson GS, Dickason WL, Gaisford JC, Hanna DC. Tumors of salivary glands: An analysis of 752 cases. Plastic and Reconstructive Surgery.1975;55(2):131-8.

Dave PN, Parikh UR, Goswami HM, Jobanputra GP, Panchal NV, Shah AM. Histopathological study of salivary gland lesions. International Journal of Current Research and Review. 2015;7(17):45.

Soni D, Mathur K, Yadav A, Kumar V. Histopathological spectrum of salivary gland lesions in tertiary care center at SMS Medical College Jaipur Rajasthan. Int J Med Res Pro. 2016;2:209-15.

Laishram RS, Kumar KA, Pukhrambam GD, Laishram S, Debnath K. Pattern of salivary gland tumors in Manipur, India: A 10 year study. South Asian journal of cancer. 2013;2(4):250.

Frable MA, Frable WJ. Fine-needle aspiration biopsy of salivary glands. The Laryngoscope. 1991;101(3):245-9.

Cristallini EG, Ascani S, Farabi R, Liberati F, Macciò T, Peciarolo A, Bolis GB. Fine needle aspiration biopsy of salivary gland, 1985-1995. Acta cytologica. 1997;41(5):1421-5.

Boccato P, Altavilla G, Blandamura S. Fine needle aspiration biopsy of salivary gland lesions. A reappraisal of pitfalls and problems. Acta cytologica. 1998;42(4):888-98.

Stewart CJ, MacKenzie K, McGarry GW, Mowat A. Fine‐needle aspiration cytology of salivary gland: a review of 341 cases. Diagnostic cytopathology. 2000;22(3):139-46.

Rajwanshi A, Gupta K, Gupta N, Shukla R, Srinivasan R, Nijhawan R, Vasishta R. Fine‐needle aspiration cytology of salivary glands: diagnostic pitfalls—revisited. Diagnostic cytopathology. 2006;34(8):580-4.