DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20210406

The duration of antiretrovirals administration and hearing impairment in HIV-infected patients

Bima Riantardo Hafni, Dian Ayu Ruspita, Muchlis Achsan Udji Sofro, Riece Hariyati, Zulfikar Naftali, Willy Yusmawan, Anna Mailasari K. D., Muyassaroh .

Abstract


Background: Antiretrovirals (ARV) treatment in HIV has a role in preventing HIV transmission, because ARV drugs have a mechanism of action to prevent viral replication which gradually reduces the amount of virus in the blood. Nucleoside analogue reverse transcriptase inhibitors (NRTIs) are a type of ARV that has side effects of hearing impairment. This research was purposed to determine the relationship between the duration of ARV administration with hearing impairment HIV-infected patients.

Methods: We used a cross-sectional design in HIV patients aged 19-59 years who were undergoing ARV treatment at Dr. Kariadi Semarang. We identified 91 patients whose complaints of hearing impairment (tinnitus and/or hearing loss) obtained from the history. We analyzed the data with the chi-square test, fisher's exact and yate correlation.

Results: There were 91 respondents who received ARVs. Male 62 people (68.1%) female 29 people (31.9%), the youngest was 19 years old, the oldest was 52 years old, mean age was 34.8 years+ 8,04. The duration of ARV administration was not associated with tinnitus (p=0.385), hearing loss (p=0.344), and hearing impairment (p=0.454).

Conclusions: The duration of ARV administration was not associated with tinitus, hearing loss, hearing impairment.


Keywords


Human immunodeficiency virus, Antiretroviral, Hearing impairment

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References


Powderly WG. Opportunistic infections. In: Hoffmann C, Rockstroh JK, eds. Current Opinion in Infectious Diseases.Vol 9. Hamburg: Medizin Fokus Verlag. 1996:23-7.

Obasikene G, Amadi IF, Ibekwe TS, Ezeanolue BC, Ogisi FO. The effect of cd4 count level on the middle ear dynamics of HIV infected patients. East Afr Med J. 2014;91(1):29-32.

Kemenkes RI. Laporan HIV/AIDS Triwulan 1 Tahun 2017. Jakarta: Depkes RI. 2017. Available at: http://siha.depkes.go.id/portal/files_upload/Laporan_HIV_AIDS_TW_4_Tahun_2017__1_.pdf. Accessed February 10, 2019.

Buriti AKL, Oliveira SH dos S, Muniz LF. Hearing loss in children with HIV/AIDS. CODAS. 2013;25(6):513-20.

Matas CG, Angrisani RG, Leite Magliaro FC, Segurado AAC. Audiological manifestations in HIV-positive adults. Clinics. 2014;69(7):469-75.

Fokouo JVF, Vokwely JEE, Noubiap JJN, Nouthe BE, Zafack J, Ngom ESM et al. Effect of HIV infection and highly active antiretroviral therapy on hearing function: A prospective case-control study from Cameroon. JAMA Otolaryngol-Head Neck Surg. 2015;141(5):436-41.

Minhas RS, Iyengar DA, Thakur JS, Azad RK. Effect of HIV and antiretroviral treatment on auditory functions. Int Arch Otorhinolaryngol. 2018;22(4):378-81.

Keppler H, Ingeborg D, Sofie D, Bart V. The effects of a hearing education program on recreational noise exposure, attitudes and beliefs toward noise, hearing loss, and hearing protector devices in young adults. Noise Heal. 2015;17(78):253-62.