Comparison of lipid profile in diabetic patients presenting with cardiac diseases

Authors

  • Nakul Johri Department of Medicine, Rohilkhand Medical College and Hospital, Bareilly, Uttar Pradesh, India
  • Darshan Mehra Department of Medicine, Rohilkhand Medical College and Hospital, Bareilly, Uttar Pradesh, India
  • Rajashree Kadam Department of Ophthalmology, Dr. Babasaheb Ambedkar Hospital, Andheri, Mumbai, Maharashtra, India
  • Rajib Ratna Chaudhary Department of Medicine, Rohilkhand Medical College and Hospital, Bareilly, Uttar Pradesh, India
  • Mukund Shyam Sarda Department of Medicine, Rohilkhand Medical College and Hospital, Bareilly, Uttar Pradesh, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20210874

Keywords:

Dyslipidemia, Diabetic, Cardiac disease

Abstract

Background: Diabetes mellitus (T2DM) is the most common metabolic disorder in human beings. It is a group of metabolic disorders which causes a decrease in the insulin secretion and /or resistance in its functions and/ or actions. It is the commonest prevalent metabolic disorder which is rapidly increasing all over the world. The purpose of this study was to evaluate the serum lipid levels in diabetic patients who presented to the OPD or the IPD with cardiac diseases.

Methods: It was a cross sectional observational study conducted for period of 18 months (June 2018-December 2019). Study was done in 111 patients diagnosed with T2 DM (diagnosed according to ADA criteria) attending OPD and in admitted in the Rohilkhand Medical College and Hospital (RMCH), Bareilly, Uttar Pradesh.

Results: A total of 111 patients were taken for this study and in the present study we found that 47.7% patients had Coronary artery disease (CAD), 21.6% had myocardial ischemia (SMI), 36% diastolic dysfunction (DF) and 28,8% had systolic dysfunction (SDF). About half of the patients were above 50 years (50.5%) followed by 40-50 (47.7%) and <40 years were in a small number (1.8%). More than half of the males (56.6%) and 28.6% of females were in 40-50 years of age.

Conclusions: We found in our study a significant association of high triglyceride levels with the silent myocardial ischemia (SMI) in diabetic patients but no significant relation with the high levels of cholesterol.

 

References

Bhattacharya S, Dey D, Roy SS. Molecular mechanism of insulin resistance. J Biosci. 2007;32:405-13.

Johansen JS, Harris AK, Rychly DJ, Ergul A. Oxidative stress and the use of antioxidants in diabetes: linking basic science to clinical practice. Cardiovasc Diabetol. 2005;4:5.

Kannel WB, McGee DL. Diabetes and cardiovascular risk factors: the Framingham study. Circulation. 1979;59:8-13.

Gibbons GF. Hyperlipidaemia of diabetes. Clin Sci. 1988;71:477-86.

Beckman JA, Creager MA, Libby P. Diabetes and atherosclerosis, epid, pathophysiology, and management: Review article. JAMA. 2002;287(19):2570-81.

Navab M, Berliner JA, Watson AD, Navab M, Berliner JA, Watson AD, et al. The yin and yang of oxidation in the development of the fatty streaks: a review based on the 1994 George Lyman Duff Memorial Lecture. Arterioscler Thromb Vasc Biol. 1996;16:831-42.

Krentz AJ. Lipoprotein abnormalities and their consequences for patients with type 2 diabetes. Diabetes Obes Metab. 2003;5(1):19-27.

West KM, Ahuja MM, Bennett PH, Czyczk A, de Acosta OM, Fuller JH, et al. The role of circulating glucose and triglyceride concentrations and their interactions with other "risk factors" as determinants of arterial disease in nine diabetic population samples from the WHO Multinational Study. Diabetes Care. 1983;6:361-9.

Fontbonne A, Eschwege E, Cambien F, Richard JL, Ducimetiere P, Thibult N, et al. Hypertriglyceridemia as a risk factor of coronary heart disease mortality in subjects with impaired glucose tolerance or diabetes: results from the 11-year follow-up of the Paris Prospective study. Diabetologia. 1989;32:300-4.

Wang TD, Lee CM, Wu CC, Lee TM, Chen WJ, Chen MF, et al. The effects of dyslipidemia on left ventricular systolic function in patients with stable angina pectoris. Atherosclerosis. 1999;146(1):117-24.

Downloads

Published

2021-02-25

How to Cite

Johri, N., Mehra, D., Kadam, R., Chaudhary, R. R., & Sarda, M. S. (2021). Comparison of lipid profile in diabetic patients presenting with cardiac diseases. International Journal of Research in Medical Sciences, 9(3), 761–764. https://doi.org/10.18203/2320-6012.ijrms20210874

Issue

Section

Original Research Articles