Published: 2021-02-25

Psychological impact among cancer patients undergoing chemotherapy in Bundelkhand region, Central India

Sushil Gour, Rajesh Kumar Maurya, Punya Pratap Singh, Vrashbhan Ahirwar, Mahendra Dhakar, Prashant Maravi


Background: A cancer diagnosis can have a significant impact on mental health and wellbeing. Cancer is the second most common cause of death after heart diseases and it accounted for 9.6 million deaths worldwide in 2018. Various individual psychosocial and contextual factors potentially contribute to the development of anxiety and depression among people with cancer. In comparison with general people, the prevalence of anxiety and depression is frequently found to be higher among cancer patient, but estimates vary due to various factors, such as the type of cancer, treatment setting, and prognosis of disease. The present study was conducted to find out the estimate of depression in cancer patients undergoing chemotherapy and determine the various factors associated with depression.

Methods: A cross-sectional study was conducted amongst cancer patients undergoing chemotherapy at Department of Oncology, Government Bundelkhand Medical College and Hospital, Sagar from January to April 2019. 150 participants were interviewed using predesigned questionnaire based on the Beck’s depression inventory.

Results: Out of 150 cancer patients, 83 (55.3%) were found to be depressed. Depression was comparatively higher in patients’ ≥50 years; in males. Among the study patients, 83 (55.33%) had depression of which 21 (25.3%) had borderline clinical depression, 54 (65.06%) had moderate depression and 08 (9.6%) had severe depression.

Conclusions: The study revealed depression in majority of patients receiving chemotherapy. Treatment of cancer patients need to be complemented by psychological support. Research is urgently needed into the possible impacts of long term effects of cancer treatment on mental health.


Mental health, Chemotherapy, Cancer patients, Depression

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Defining Cancer". National Cancer Institute.

Sarafino E. Health Psychology: Bio Psychosocial Interactions. 2nd ed. New York: John Wiley and Sons. 1994.

Friedenbergs I, Kaplan E. Cancer. In: Eisenberg M, Glueckauf R, Zaretsky H, editors. Medical Aspects of Disability: A Handbook for the Rehabilitation Professional. New York: Springer. 1993;105.

McLean LM, Jones JM. A review of distress and its management in couples facing end-of-life cancer. Psychooncol. 2007;16:603-16.

Burgess C, Cornelius V, Love S, Graham J, Richards M, Ramirez A. Depression and anxiety in women with early breast cancer: Five year observational cohort study. BMJ. 2005;330:702-5.

Shapiro SL, Lopez AM, Schwart GE, Bootzin R, Fiqueredo AJ, Braden CJ, et al. Quality of life and breast cancer relationships to psychosocial variables. J Clin Psychol. 2001;57:501-19.

Zhu J, Fang F, Sjölander A, Fall K, Adami HO, Valdimarsdóttir U. First-onset mental disorders after cancer diagnosis and cancer-specific mortality: a nationwide cohort study. Ann Oncol. 2017;28(8):1964-9.

Ball H, Moore S, Leary A. A systematic literature review comparing the psychological care needs of patients with mesothelioma and advanced lung cancer. Eur J Oncol Nurs. 2016;25:62-7.

Smith HR. Depression in cancer patients: pathogenesis, implications and treatment (review). Oncol Lett. 2015;9(4):1509-14.

Katon WJ. Epidemiology and treatment of depression in patients with chronic medical illness. Dialogues Clin Neurosci. 2011;13:7-23.

Williams S, Dale J. The effectiveness of treatment for depression/ depressive symptoms in adults with cancer: A systematic review. Br J Cancer. 2006;94:372-90. Last accessed on 01 November, 2020.

Walker J, Holm Hansen C, Martin P, Sawhney A, Thekkumpurath P, Beale C, et al. Prevalence of depression in adults with cancer: A systematic review. Ann Oncol. 2013;24:895-900.

Katon WJ. Epidemiology and treatment of depression in patients with chronic medical illness. Dialogues Clin Neurosci. 2011;13:7-23.

Haig RA. Management of depression in patients with advanced cancer. Med J Aust. 1992;156:499-503.

Anderson BL, Anderson B, de Prosse. Controlled prospective longitudinal study of women with cancer II. Psychological outcomes. J Consult Clin Psychol. 1989;57:692-97.

Vaidya SS, Sharma SK. Depression in cancer patients undergoing chemotherapy in a tertiary care hospital: a cross- sectional study. Int J Community Med Public Health. 2019;6:3102-6.

Bhattacharyya S, Bhattacharjee S, Mandal T, Das DK. Depression in cancer patients undergoing chemotherapy in a tertiary care hospital of North Bengal, India. Indian J Public Health. 2017;61:14-18.

Polikandrioti M, Evaggelou E, Zerva S, Zerdila M, Koukoularis D, Kyritsi E. Evaluation of depression in patients undergoing chemotherapy. Health Sci J. 2008;2:162-72.

Pandey M, Sarita GP, Devi N, Thomas BC, Hussain BM, Krishna R. Distress, anxiety, and depression in cancer patients undergoing chemotherapy. World J Surg Oncol. 2006;4:68.

Yusof S, Zakaria FN, Hashim NK, Dasiman R. Depressive symptoms among cancer patients undergoing chemotherapy. Procedia Soc Behav Sci. 2016;34:185-92.

Jang S, Ackler J, Braitman L, Tester W. Depression and quality of life in cancer undergoing chemotherapy: relation between Zung self-rating depression scale and functional assessment of cancer therapy-general. Commun Oncol. 2012;9:122-6.