DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20210890

Clinicobiochemical and pathological correlation in alcoholic liver disease among Indian patients

Atanu Roy Chowdhury, Ramkrishna Brahmachari, Soumyojit Saha

Abstract


Background: Alcohol is one of the leading causes of “preventable” morbidity and mortality worldwide. It is associated with liver damage. A gray area is temporal relation between clinico-biochemical severity and histological changes in liver, neither this issue has been widely studied.

Methods: A hospital based cross sectional clinico-pathological pilot study was undertaken in a tertiary care hospital in West Bengal in patients with a history of alcohol intake who had been admitted in the inpatient department of medicine. Assessment of patients with history of alcohol intake with respect to clinical, biochemical and histopathological examination was performed. The correlation between clinico-biochemical severity and histopathological stages in cases of alcoholic liver disease was evaluated.

Results: There was a significant correlation between clinico-biochemical severity and liver biopsy changes. The severity of histopathological changes of alcoholic liver disease was found to correlate significantly with the severity of abdominal parameters with Pearson correlation cofactor of 0.819.

Conclusions: Both the clinic-biochemical severity and histological changes had no correlation with the duration of alcohol intake in contrast to earlier studies which had demonstrated a definite correlation of alcoholic liver disease (ALD) with both the amount and duration of alcohol intake. Larger studies will be required to substantiate the findings of this study.

 


Keywords


ALD, Clinical, Biochemical and histopathological

Full Text:

PDF

References


Sachdeva A, Chandra M, Choudhary M , Dayal P, Anand KS. Alcohol-Related Dementia and Neurocognitive Impairment: A Review Study. Int J High Risk Behav Addict. 2016;5(3):27976.

Sivapuram MS, Nagarathna R, Anand A, Patil S, Singh A, Nagendra HR. Prevalence of Alcohol and Tobacco Use in India and Implications for COVID-19 - Niyantrita Madhumeha Bharata Study Projections. J Med Life. 2020;13(4):499-509.

Gopikrishnan SK, Ponraj DGS, Newtonraj A, Purty AJ, Manikandan M, Vincent A. Prevalence and determinants of Alcohol use in a remote rural area in South India: A community-based cross-sectional study. J Family Med Prim Care. 2020;9(8):4333-6.

WHO Alcohol fact sheet. Available at: https://www.who.int/health-topics/alcohol. Accessed on: 26 February 2021.

Rocco A, Compare D, Angrisani D, Zamparelli MS, Nardone G. Alcoholic disease: Liver and beyond. World J Gastroenterol. 2014;20(40):14652-9.

Crabb DW. Pathogenesis of alcoholic liver disease: newer mechanisms of injury. Keio J Med. 1999;48:184-8.

Crawford JM. Histologic findings in alcoholic liver disease. Clin Liver Dis. 2012;16:699-716.

Theise ND. Histopathology of Alcoholic Liver Disease. Clin Liver Dis. 2013;2:64-7.

World Health Organization. Burden and socio-economic impact of alcohol: The Bangalore study. WHO South East Asian Region Office Alcohol Control Series 1. 2006. Available at: http://www.searo.who.int/en/Section1174/Section1199/Section 2278_12017.htm. Accessed on: 29 January 2021.

Lieber CS. Medical and nutritional complication of alcoholism. New York: Plenum Press. 1992.

Chedid A, Mendenhall CL, Gartside P, French SW, Chen T. Prognostic factors in alcoholic liver disease. Am J Gastroenterol. 1991;86:210-6.

Mohan D, Chopra A. Ray R and Sethi H. Alcohol consumption patterns in India: a cross sectional study in Demers A, Room R, Bourgault C (Eds). Surveys of drinking patterns and problems in seven developing countries Geneva, World Health organization. 2001;103-14.

Worner TM, Leiber CS. Perivenular fibrosis as precursor lesion of cirrhosis. JAMA. 1985;254:627-30.

Hasumura Y,Minato Y, Nishimura M eatic fibrosis in alcoholics: morphologic characteristics, clinical diagnosis and natural course. Pathobiol Hepatic Fibrosis. 1985;7:13-24.

Mak KM, Leiber CS. Lipocytes and transitional cells in alcoholic liver disease: a morphometric study. Hepatology. 1988;8:1027-33.

Friedman SL. The cellular basis of hepatic fibrosis: Mechanisms and treatment strategies. N Engl J Med. 1993;328:1828-35.

Becker U, Deis A, Sorensen TI, Gronbaek M, Muller CF, et al. Prediction of risk of liver disease by alcohol intake, sex and age: a prospective population study. Hepatology. 1996;23:1025-9.

Kamper-Jorgensen M, Gronbaek M, Tolstrup J, Becker U. Alcohol and cirrhosis: dose-response or threshold effect. J Hepatol 2004;41:25-30.

Lu XL, Luo JY, Tao M, Gen Y, Zhao P, Zhao HL, et al. risk factors for alcoholic liver disease in China. World J Gastroenterol. 2004;10:2423-6.

Frezza M, di Padova C, Pozzoto G, Terpin M, Baraona E, Lieber CS. High blood alcohol levels in women. The role of decreased gastric alcohol dehydrogenase activity and first pass metabolism. N Eng J Med. 1990;322:95-9.

Naveau S, Giraud V, Borotto E, Aubert A, Capron F, Chaput JC. Excess weight risk factor for alcoholic liver disease. Hepatology. 1997;25:108-11.

McClain CJ, Song Z, Brave SS, Hill DB, Deacuic I. Recent advances in alcoholic liver disease. IV. Dysregulated cytokine metabolism in alcoholic liver disease. Am J Physiol Gastrointest Liver Physiol. 2004;287:497-502.

Menon KV, Goves GJ, Shah VH. Pathogenesis, diagnosis and treatment of alcoholic liver disease. Mayo Clin Proc. 2001;76:1021-9.

Cohen JA, Kaplan MM. The SGOT/SGPT ratio- an indicator of alcoholic liver disease. Dig Dis Sci. 1979;24:835-8.

Nyblom H, Berggren U, Balldin J, Olsson R. High AST/ALT ratio may indicate advanced alcoholic liver disease rather than heavy drinking. Alcohol. 2004;39:336-9.

Niemela O. Biomarker in alcoholism. Clin Chim Acta. 2007;377:39-49.

Talley NJ, Roth A, Woods J, Hench V. Diagnosoic value of liver biopsy in alcoholic liver disease. J Clin Gastroenterol. 1988;10:647.

Bellentani S, Saccoccio G, Costa G. Drinking Habits As Cofactors Of Risk For Alcohol Induced Liver Disease. Gut. 1997;41:845-50.

Narawane NM, Bhatia S, Abraham P, Sanghani S, Sawant SS. Consumption of ‘country liquor’ and its relation to alcoholic liver disease in Mumbai. JAPI. 1998;46:6.