Published: 2021-04-28

Evaluation of anti-ulcer activity of 4-hydrooxy benzalydehide against NSAIDs induced ulcers in rats

Rupali V. Jadhav, V. K. Redasani, Shankar B. Kalbhare, Karishma Yadav, Aryan Langeh, Amuruta Tidke


Background: The aim of this study was to evaluate antiulcer activity of 4-hydroxybenzaldehyde against NSAIDs induced ulcer in rats based differences in its morphology, distance with other external landmarks and also to sigmoid and transverse sinuses.

Methods: The antiulcer activity of 4-HBD was evaluated using pylorus ligation-aspirin induced ulcer method. Animals of this models were treated with 4-HBD (50mg/kg, 100mg/kg and 150mg/kg).

Results: It has been observed that 4-HBD at low dose (50mg/kg), intermediate dose (100mg/kg) and high dose (150mg/kg) showed significant increase in pH, significant decrease in gastric volume, significant decrease in ulcer index and significant decrease in total acidity.

Conclusions: The impact of 4-HBD therapy with intermediate (100mg/kg, p.o.) dose was observed to be similar with the positive control group.




Anti-inflammatory, Antioxidant, NSAIDs, Peptic ulcers, Pylorus ligation, Wound healing

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Kang CW, Han YE, Kim J, Oh JH, Cho YH, Lee EJ. Accelerates acute wound healing through activation of focal adhesion signalling in keratinocytes. Sci Rep. 2017;7:1-11.

Reddy PS, Begum N, Mutha S, Bakshi V. Beneficial effect of curcumin in letrozole induced polycystic ovary syndrome. Asian Pacific J Reprod. 2016;5(2):116-22.

Kalbhare SB, Bhandwalkar MJ, Pawar RK, Sagre AR. Sodium alginate cross-linked polymeric microbeads for oral sustained drug delivery in hypertension : formulation and evaluation. Curr Sci. 2020;10(3):153-7.

Yi W, Cao R, Peng W. Synthesis and biological evaluation of novel 4-hydroxybenzaldehyde derivatives as tyrosinase inhibitors. Int J Pharm Pharm Sci. 2010;45:639-46.

Cavalcante Y, Goulart F, Sela VR. Evaluation of gastric anti-ulcer activity in a hydro- ethanolic extract from kielmeyera coriacea. Curr Sci. 2005;48:211-6.

Sahoo SK, Sahoo HB, Priyadarshini D, Soundarya G, Rani KU. Antiulcer activity of ethanolic extract of Salvadora indica leaves on albino rats. Biochem. 2016:7-10.

Bruder EA, Ball IM, Ridi S, Pickett W, Hohl C. Single induction dose of etomidate versus other induction agents for endotracheal intubation in critically ill patients. Cochrane Database Syst Rev. 2015;10:222-5.

Muniappan M, Sundararaj T. Antiinflammatory and antiulcer activities of Bambusa arundinacea. Biochem. 2003;88:161-7.

Pal S, Chaudhuri AKN. Studies on the anti-ulcer activity of a Bryophyllum pinnatum leaf extract in experimental animals. J Ethnopharmacol. 1991;33(1-2):97-102.

Thomas LM. Formulation and evaluation of floating oral in-situ gel of metronidazole. Int J Pharm Pharm Sci. 2014;6(10):265-9.

Ahmad AA, Kasim KF, Ma’Radzi AH, Gopinath SCB. Peptic ulcer: current prospects of diagnostic and nanobiotechnological trends on pathogenicity. Process Biochem. 2019;85:51-9.

Rajkapoor B, Anandan R, Jayakar B. Anti-ulcer effect of Nigella sativa Linn. against gastric ulcers in rats. Curr Sci. 2002;82(2):177-9.