Blood urea nitrogen as an early predictor of severity in acute pancreatitis

Authors

  • Syed Mushtaq A. Shah Department of Surgery, GMC, Srinagar, Jammu and Kashmir, India
  • Syed Aadil S. Andrabi Department of Surgery, GMC, Srinagar, Jammu and Kashmir, India http://orcid.org/0000-0002-5986-5151
  • Azhar-un-Nisa Quraishi Department of Gynaecology and Obstetrics, SKIMS, Soura, Jammu and Kashmir, India
  • Ravi Kumar Department of Surgery, GMC, Srinagar, Jammu and Kashmir, India
  • Tahir S. Khan Department of Surgery, GMC, Srinagar, Jammu and Kashmir, India
  • Aadil P. Shah Department of Surgery, GMC, Srinagar, Jammu and Kashmir, India
  • Bilal A. Bhat Department of Surgery, GMC, Srinagar, Jammu and Kashmir, India
  • Tajdin Wani Department of Surgery, GMC, Srinagar, Jammu and Kashmir, India
  • Yaser H. Wani Department of Surgery, GMC, Srinagar, Jammu and Kashmir, India
  • Younis Bashir Department of Surgery, GMC, Srinagar, Jammu and Kashmir, India
  • Bilal A. Lone Department of Surgery, GMC, Srinagar, Jammu and Kashmir, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20211343

Keywords:

Acute pancreatitis, Blood urea nitrogen, Mortality, Resuscitation

Abstract

Background: Acute pancreatitis presents as acute abdominal pain and is usually associated with raised pancreatic enzyme levels in the blood or urine. Aims and objectives of the study was to evaluate the role of serial BUN measurement as an early prognostic marker of acute pancreatitis.

Methods: From each patient detailed history was taken, general and systemic examination were done and relevant investigations were conducted. BUN was repeated after 24 hours and the change in the level of BUN was noted. Imaging in the form of CT after 72 hours of admission were performed in each patient. The severity of acute pancreatitis was gauged by modified CTSI and the same was compared to the change in BUN values over first 24 hours of admission.

Results: Mean BUN values at ‘0’ hour in severe acute pancreatitis and non-severe acute pancreatitis were 31.91±6.79 and 15.44±5.95 mg/dl, respectively. The difference between the two groups was statistically significant with p value of <0.001. Similarly, the difference in BUN values at ‘24’ hours between the two groups was statistically significant. BUN value ≥23 mg/dl at ‘0’ hour was found to be the optimal cut off for determining the severity of pancreatitis with sensitivity of 91.3%. BUN ≥25 mg/dl at 24 hours was found to be the optimal cut-off for determining the severity of acute pancreatitis with sensitivity of 95.7%.

Conclusions: BUN as a single marker for acute pancreatitis can be useful as it is easy to perform and cheap marker to predict severity without the need for complex calculations.

 

Author Biographies

Syed Mushtaq A. Shah, Department of Surgery, GMC, Srinagar, Jammu and Kashmir, India

Professor, Department of Surgery

Syed Aadil S. Andrabi, Department of Surgery, GMC, Srinagar, Jammu and Kashmir, India

Postgraduate Scholar, Department of General Surgery Srinagar

Azhar-un-Nisa Quraishi, Department of Gynaecology and Obstetrics, SKIMS, Soura, Jammu and Kashmir, India

Senior Resident, Department of Obstetrics and Gynaecology

Ravi Kumar, Department of Surgery, GMC, Srinagar, Jammu and Kashmir, India

Postgraduate Scholar Department of General Surgery Srinagar

Tahir S. Khan, Department of Surgery, GMC, Srinagar, Jammu and Kashmir, India

Lecturer, Department of General Surgery

Aadil P. Shah, Department of Surgery, GMC, Srinagar, Jammu and Kashmir, India

Senior Resident, Department of Surgery

Bilal A. Bhat, Department of Surgery, GMC, Srinagar, Jammu and Kashmir, India

Senior Resident, Department of Surgery

Tajdin Wani, Department of Surgery, GMC, Srinagar, Jammu and Kashmir, India

Postgraduate Scholar, Department of General Surgery Srinagar

Yaser H. Wani, Department of Surgery, GMC, Srinagar, Jammu and Kashmir, India

Postgraduate Scholar, Department of General Surgery Srinagar

Younis Bashir, Department of Surgery, GMC, Srinagar, Jammu and Kashmir, India

Postgraduate Scholar, Department of General Surgery Srinagar

Bilal A. Lone, Department of Surgery, GMC, Srinagar, Jammu and Kashmir, India

Postgraduate Scholar, Department of General Surgery Srinagar

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Published

2021-03-26

How to Cite

Shah, S. M. A., Andrabi, S. A. S., Quraishi, A.- un-N., Kumar, R., Khan, T. S., Shah, A. P., Bhat, B. A., Wani, T., Wani, Y. H., Bashir, Y., & Lone, B. A. (2021). Blood urea nitrogen as an early predictor of severity in acute pancreatitis. International Journal of Research in Medical Sciences, 9(4), 1015–1019. https://doi.org/10.18203/2320-6012.ijrms20211343

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Section

Original Research Articles