Effect of sitagliptine and vildagliptine on carotid intima/media thickness in patients with type 2 diabetes mellitus

Authors

  • Ganeswar Sethy Department of Internal Medicine, MKCG Medical College, Berhampur, Odisha, India
  • Geetanjali Sethy Department of Pediatrics, PRM Medical College, Baripada, Odisha, India
  • Ranjit Rout Department of Internal Medicine, MKCG Medical College, Berhampur, Odisha, India
  • Abinash Panda Department of Pharmacology, MKCG Medical College, Berhampur, Odisha, India
  • Adya Anwesha Vimsar, Odisha, India
  • Prasanta Purohit MRU, MKCG Medical College, Berhampur, Odisha, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20211874

Keywords:

Common carotid artery intima/media thickness, Dipeptidyl peptidase-4 inhibitors, Type -2 diabetes mellitus

Abstract

Background: Atherosclerosis is a known macro-vascular complication of diabetes mellitus. Gliptins, as a drug class have non-glycemic beneficial action on blood vessels and in addition to their anti-diabetic effects. This study was carried out to find out the effects of sitagliptin and vildagliptin on common carotid intima-media thickness in patients with type 2 diabetes mellitus.

Methods: The observational longitudinal study was carried out on 100 patients with 80 patients with confirmed clinical diagnosis of type 2 diabetes mellitus. They were divided in 3 groups. Group A and Group B received drugs, either sitagliptine or vildagliptin and Group C control group did not receive any drug. High resolution B-mode ultrasonography was carried out for the measurement of intima-media thickness (IMT) of both the common carotid arteries (CCA). Data analysis was done using Microsoft excel spreadsheet and GraphPad Prism version 7.0 (free trial version) software package. A p value of ≤ 0.05 was considered as statistically significant.

Results: The baseline value for the control group was 0.812±0.0748 mm for both the right and left CCA. At 52 weeks the CCA IMT for the right and left CCA were 1.0185± 0.272 mm and 0.936±0.149 mm respectively. At 104 weeks the CCA IMT for the right and left CCA were 0.923±0.243 mm and 0.859±0.123 mm respectively.

Conclusions: There was a significant decrease in carotid intima-media thickness in patients of type-2 diabetes mellitus treated with sitagliptin and vildagliptin.

Author Biographies

Ganeswar Sethy, Department of Internal Medicine, MKCG Medical College, Berhampur, Odisha, India

Internal medicine , Associate Professor

Geetanjali Sethy, Department of Pediatrics, PRM Medical College, Baripada, Odisha, India

Pediatrics, Professor

Ranjit Rout, Department of Internal Medicine, MKCG Medical College, Berhampur, Odisha, India

Internal medicine , Post graduate trainee

Adya Anwesha, Vimsar, Odisha, India

Medical student

Prasanta Purohit, MRU, MKCG Medical College, Berhampur, Odisha, India

Research Scientist , Multidisciplinary research unit

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Published

2021-04-28

How to Cite

Sethy, G., Sethy, G., Rout, R., Panda, A., Anwesha, A., & Purohit, P. (2021). Effect of sitagliptine and vildagliptine on carotid intima/media thickness in patients with type 2 diabetes mellitus. International Journal of Research in Medical Sciences, 9(5), 1388–1393. https://doi.org/10.18203/2320-6012.ijrms20211874

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Original Research Articles