Histopathological study of epithelial ovarian tumors with special reference to human epidermal growth factor receptor-2/NEU and CA-125 expression

Authors

  • Shobnam Bahar Barbhuiya Department of Pathology, Silchar Medical College and Hospital, Silchar, Assam, India
  • Ananya Debnath Department of Pathology, Silchar Medical College and Hospital, Silchar, Assam, India
  • Monoj Kumar Deka Department of Pathology, Silchar Medical College and Hospital, Silchar, Assam, India
  • Shah Alam Sheikh Department of Pathology, Silchar Medical College and Hospital, Silchar, Assam, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20212228

Keywords:

Epithelial ovarian cancer, HER-2/NEU, CA-125

Abstract

Background: Ovarian cancer is the second most common gynecologic malignancy. The aim of the study was to evaluate the tissue expression of HER-2/NEU and CA-125 in various epithelial ovarian carcinoma and assess the prognostic significance.

Methods: A retrospective study was done in 76 cases of ovarian tumor. IHC was done in 16 cases of epithelial ovarian cancer with HER-2/NEU and CA-125.

Results: Total number of cases were 76. Out of these 76 cases, 22 cases were malignant. 16 cases were malignant epithelial ovarian cancer. The highest incidence of malignant tumor was seen in the 41-50 years age group with 9 cases (11.84%). Out of 11 serous adenocarcinoma, 9 cases (81.8%) showed tissue expression of CA-125 and rest 2 cases (18.18%) did not show expression. All the 5 cases (100%) of mucinous adenocarcinoma did not show any tissue expression of CA-125. HER-2/NEU expression was positive in 7 out of 16 cases that is 43.75% and negative expression was seen in 9 out of 16 cases that is 56.25% of cases. Maximum HER-2/NEU positivity is seen among grade 3 tumors, that is (62.5%) (5 out of 8 cases).  

Conclusions: The incidence of epithelial ovarian tumors are more common. The tissue expression of CA-125 on malignant epithelial ovarian tumors was studied, which showed positive expression in serous cystadenocarcinomas, but not in mucinous cystadenocarcinoma. HER-2/NEU expression was seen to be increasing with advanced grade of the tumors.

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Published

2021-05-27

How to Cite

Barbhuiya, S. B., Debnath, A., Deka, M. K., & Sheikh, S. A. (2021). Histopathological study of epithelial ovarian tumors with special reference to human epidermal growth factor receptor-2/NEU and CA-125 expression. International Journal of Research in Medical Sciences, 9(6), 1628–1632. https://doi.org/10.18203/2320-6012.ijrms20212228

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Original Research Articles