Premalignant lesions of the oral cavity: current perspectives

Authors

  • Santosh Kumar Swain Department of Otorhinolaryngology- Head and Neck Surgery, IMS and SUM hospital, Kalinganagar, Bhubaneswar, Odisha, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20212259

Keywords:

Premalignant lesions, Oral cavity, Leukoplakia, Erythroplakia

Abstract

Premalignant lesions of the oral cavity are also called as potentially malignant disorders. The common premalignant lesions of the oral cavity include leukoplakia, oral submucous fibrosis (OSMF) and oral erythroplakia. These lesions have a very high malignant transformation rate. The exact etiological factors for development of the premalignant lesions of the oral cavity are not fully understood till date. Use of tobacco, alcohol drinking, chewing betel quid containing areca nut and solar rays are important etiological factors for resulting the premalignant lesions of the oral cavity. Early diagnosis is an important step for preventing the malignant transformations of these lesions and can be also life-saving. There are several treatment options including conservative to surgical for eliminating the premalignant lesions of the oral cavity. The aim of this study was to discuss the details of epidemiology, etiopathology, clinical presentations, diagnosis and current treatment of the premalignant lesions of the oral cavity.  

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References

Wu JH, Zhou Y, Luo XY. Role of narrow band imaging in the diagnosis of premalignant and malignant lesions of oral cavity. Chinese J of Otorhinolaryngol head and neck surg. 2020;55(2):104-8.

Warnakulasuriya S, Johnson NW, Waal I. Nomenclature and classification of potentially malignant disorders of the oral mucosa. J Oral Pathol Med. 2007;36(10):575-80.

Swain SK, Debta P. Nonsurgical treatment of oral cavity leukoplakia. Matrix Sci Medica. 2020;4(4):91.

Swain SK, Behera IC, Mohanty JN. Laryngeal manifestation due to smoking among the pediatric age group-Our experiences at an Indian teaching hospital. Archives of Med and Health Sci. 2019;7(2):186.

Jemal A, Murray T, Ward E, Samuels A, Tiwari RC, Ghafoor A, et al. Cancer statistics, 2005. CA Cancer J Clin. 2005;55(1):10-30.

Kindly replace this reference with below one

Kao YH, Chen CN, Chiang JK, Chen SS, Huang WW. Predicting factors in the last week of survival in elderly patients with terminal cancer: a prospective study in southern Taiwan. Journal of the Formosan Medical Association. 2009;108(3):231-9.

Banoczy J, Gintner Z, Dombi C. Tobacco use and oral leukoplakia. J Dent Educ. 2001;65(4):322-7.

Duan SM, Liu TN, Zeng X. Research progress of oral erythroplakia. Chinese J of Stomatol. 2020;55(6):421-4.

Gupta PC, Warnakulasuriya S. Global epidemiology of areca nut usage. Addict Biol. 2002;7(1):77-83.

Reichart PA, Philipsen HP. Oral erythroplakia-a review. Oral Oncol. 2005;41(6):551-61.

Waal I. Potentially malignant disorders of the oral and oropharyngeal mucosa; terminology, classification and present concepts of management. Oral Oncol. 2009;45(4):317-23.

Kruk ZA, Wierzbicka M. The tongue and floor of the mouth cancer– diagnosis and advances in treatment. Contemp Oncol. 2003;7:264-74.

Kumar M, Singh M, Suwasini S. Epidemiological and clinicopathological analysis of oral leukoplakia in Patna. Indian J Dent Sci 2021;13:12-7.

Hashibe M, Sankaranarayanan R, Thomas G, Kuruvilla B, Mathew B, Somanathan T, et al. Body mass index, tobacco chewing, alcohol drinking and the risk of oral submucous fibrosis in Kerala, India. Cancer Causes Control. 2002;13(1):55-64.

Hashibe M, Mathew B, Kuruvilla B, Thomas G, Sankarnaryanan R, Parkin DM. Chewing tobacco, alcohol, and the risk of erythroplakia. Cancer Epidemiol Biomarkers Prev. 2000;9(7):639-45.

Greer RO. Pathology of malignant and premalignant oral epithelial lesions. Otolaryngol Clin North Am. 2006;39(2):249-75.

Dietrich T, Reichart PA, Scheifele C. Clinical risk factors of oral leukoplakia in a representative sample of the US population. Oral Oncol. 2004;40: 158-63.

Gupta PC, Warnakulasuriya S. Global epidemiology of areca nut usage. Addict Biol. 2002;7(1):77-83.

Papke RL, Horenstein NA, Stokes C. Nicotinic Activity of Arecoline, the Psychoactive Element of "Betel Nuts", Suggests a Basis for Habitual Use and Anti-Inflammatory Activity. PLoS One. 2015;10(10):140907.

Tilakaratne WM, Klinikowski MF, Saku T, Peters TJ, Warnakulasuriya S. Oral submucous fibrosis: review on aetiology and pathogenesis. Oral Oncol. 2006;42:561-8.

Dufresne RG, Curlin MU. Actinic cheilitis. A treatment review. Dermatol Surg. 1997;23:15-21.

Sciubba JJ. Oral leukoplakia. Crit Rev Oral Biol Med. 1995;6(2):147-60.

Qin GZ, Park JY, Chen SY, Lazarus P. A high prevalence of p53 mutations in pre-malignant oral erythroplakia. Int J Cancer. 1999;80:345-8.

Swain SK, Nahak B, Sahu MC. Fungal laryngitis in asthmatic boy treated with inhalatory corticosteroids:A case report. Pediatria polska. 2017;92(4):453-6.

Debta P, Swain SK, Sahu MC, Debta FM, Mohanty JN. A review on oral candida as commensals and opportunistic pathogen. Indian J of Forensic Med & Toxicol. 2020;14(4):8381.

Petti S. Pooled estimate of world leukoplakia prevalence: a systematic review. Oral Oncol. 2003;39:770-80.

Dhariwal R, Ray JG, Pattanayak SM, Swain N. Oral submucous fibrosis: a report of two pediatric cases and a brief review. J Indian Soc Pedod Prev Dent. 2012;30:85-8.

Waal I. Potentially malignant disorders of the oral and oropharyngeal mucosa; terminology, classification and present concepts of management. Oral Oncol. 2009;45:317-23.

Warnakulasuriya S, Johnson NW, Waal I. Nomenclature and classification of potentially malignant disorders of the oral mucosa. J Oral Pathol Med. 2007;36:575-80.

Reichart PA, Philipsen HP. Oral erythroplakia-a review. Oral Oncol. 2005 Jul;41(6):551-61.

Villa A, Villa C, Abati S. Oral cancer and oral erythroplakia: an update and implication for clinicians. Aust Dent J. 2011;56:253-6.

Farhi D, Dupin N. Pathophysiology, etiologic factors, and clinical management of oral lichen planus, part I: facts and controversies. Clin Dermatol. 2010;28:100-8.

Batra J. Arakeri G, Brennan PA. Oral submucous fibrosis: an overview of the aetiology, pathogenesis, classification, and principles of management. Br J Oral Maxillofac Surg. 2013;587-93.

Haider SM, Merchant AT, Fikree FF, Rahbar MH. Clinical and functional staging of oral submucous fibrosis. Br J Oral Maxillofac Surg. 2000;38(1):12-5.

Schwartz RA, Bridges TM, Butani AK, Ehrlich A. Actinic keratosis:an occupational and environmental disorder. Eur Acad Dermatol Venerol. 2008;22:606-15.

Gupta S, Shah JS, Parikh S, Limbdiwala P, Goel S. Clinical correlative study on early detection of oral cancer and precancerous lesions by modified oral brush biopsy and cytology followed by histopathology. J Cancer Res Ther. 2014;10(2):232-8.

Santana SDJ, Costa MMC, Queiroz LM, Godoy GP, Silveira EJ. Actinic cheilitis: clinicopathologic profile and association with degree of dysplasia. Int J Dermatol. 2014;53(4):466-72.

Jayanthi V, Probert CS, Sher KS, Mayberry JF. Oral submucosal fibrosis--a preventable disease. Gut. 1992;33(1):4-6.

Swain SK, Debta P. Aspergillosis of the palatine tonsil. Annals of Indian Acad of Otorhinolayngol Head and Neck Surg. 2020;4(2):50.

Alam S, Ali I, Giri KY, Gokkulakrishnan S, Natu SS, Faisal M, et al. Efficacy of aloe vera gel as an adjuvant treatment of oral submucous fibrosis. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;116:717-24.

Swain SK, Sahu MC. Isolated vocal cord aspergillosis in a professional flute player-A case report. Poilsh Annals of Medicine. 2016;23:161-4.

Dolmans DE, Fukumura D, Jain RK. Photodynamic therapy for cancer. Nat Rev Cancer. 2003;3(5):380-7.

Swain SK, Sahoo L, Panda S. Voice outcome after coblation assisted microlaryngeal surgery-Our experiences at a tertiary care teaching hospital. J of Laryngol and Voice. 2020;10(1):1.

Swain SK, Samal R, Pani SK. Effect of smoking on outcome of tympanoplasty. Indian J of Otolog. 2011;17(3):120.

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Published

2021-05-27

How to Cite

Swain, S. K. (2021). Premalignant lesions of the oral cavity: current perspectives. International Journal of Research in Medical Sciences, 9(6), 1816–1822. https://doi.org/10.18203/2320-6012.ijrms20212259

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Section

Review Articles