Effect of omeprazole on patient-reported outcome measures in uninvestigated heartburn: a multi-country, multi-center observational study

Leonid B. Lazebnik; Sergey A. Alekseenko; Sergii M. Tkach; Yuriy M. Stepanov; Yury Marakhouski; Olga Zharskaya; Baurzhan I. Samikovich; Negreanu Lucian; Thein Myint; Amit Garg; Hardik Pathak; Nadezhda Pavlova

doi:10.18203/2320-6012.ijrms20211945

Authors

Leonid B. Lazebnik Moscow State University of Medicine, Russia Scientific Society Gastroenterologists of Russia
Sergey A. Alekseenko Department of Hospital Therapy, Far Eastern State Medical University, Khabarovsk, Russia
Sergii M. Tkach Ukrainian Scientific and Practical for Endocrine Surgery, Ukraine Transplantation of Endocrine Organs and Tissues of the Ministry of Health of Ukraine
Yuriy M. Stepanov Institute of Gastroenterology of the National Academy of Medical Sciences of Ukraine
Yury Marakhouski Department of Gastroenterology and Nutrition Belarus Medical Academy of Postgratuated Education (BelMAPE), Belarus
Olga Zharskaya Department of Gastroenterology and Nutrition, Belarusian Medical Academy of Post Diploma Studies (BelMAPO), Belarus
Baurzhan I. Samikovich Department of Internal Medicine, Kazakh National Medical University (KazNMU), Almaty, Kazakhstan Department of Health of Almaty, Kazakh National Medical University (KazNMU), Almaty, Kazakhstan
Negreanu Lucian Internal Medicine and Gastroenterology – Bucharest Emergency University Hospital, Romania
Thein Myint Department of Gastroenterology, Yangon General Hospital, Myanmar
Amit Garg Global Medical Affairs, Dr. Reddy’s Laboratories Ltd. Hyderabad, India
Hardik Pathak Global Medical Affairs, Dr. Reddy’s Laboratories Ltd. Hyderabad, India
Nadezhda Pavlova Dr. Reddy’s Laboratories Ltd, Moscow, Russia

DOI:

https://doi.org/10.18203/2320-6012.ijrms20211945

Keywords:

Heartburn, Gastroesophageal reflux disease, Gastritis, Omeprazole, Patient-reported outcome measures

Abstract

Background: Heartburn occurs predominantly in the upper gastrointestinal tract and is associated with gastroesophageal reflux disease (GERD) and gastritis. Omeprazole is the most prescribed proton pump inhibitor class of medication to treat heartburn related clinical conditions. To compare the efficacy of omeprazole 40 mg (as a total daily dose) and 20 mg using patient-reported outcome measures (PROMs) in patients with heartburn due to various aetiologies like non-erosive reflux disease, GERD, gastritis, dyspepsia, functional heartburn, gastro-duodenal ulcer.

Methods: Naïve patients presenting heartburn symptoms were treated with omeprazole. PROMs were assessed based on short-form-leeds dyspepsia questionnaires (SF-LDQ), work productivity activity impairment (WPAI), relief obtained using medication and, treatment satisfactory questionnaires (TSQ).

Results: A total of 18,724 patients with heartburn (GERD and gastritis; n=10,509) were treated with omeprazole (Dr. Reddy’s omeprazole [DO]/generic omeprazole [GO]/branded omeprazole [BO]) 40 mg (as a total daily dose) and 20 mg. Statistical comparative analysis showed significant improvement with omeprazole 40 mg (as a total daily dose) compared to omeprazole 20 mg in SF-LDQ, relief obtained using medication among patients with heartburn. DO 20 mg showed a greater improvement under the ‘a lot’ and ‘complete’ relief category.

Conclusions: Omeprazole 40 mg (as a total daily dose) presented better efficacy as compared to omeprazole 20 mg in patient reported outcomes. This study highlights omeprazole 40 mg as the preferred intervention for improving PROMs and quality of life in the treatment of heartburn related clinical conditions.

Author Biographies

Leonid B. Lazebnik, Moscow State University of Medicine, Russia Scientific Society Gastroenterologists of Russia

Professor of OPD of Moscow State University on Medicine, Vice-president of Russian Medical Scientific Society of Internal Medicine, President of Scientific Society Gastroenterologists of Russia

Sergey A. Alekseenko, Department of Hospital Therapy, Far Eastern State Medical University, Khabarovsk, Russia

Departmental Head, Department of Hospital Therapy, Far Eastern State Medical University, Khabarovsk, Russia.

Sergii M. Tkach, Ukrainian Scientific and Practical for Endocrine Surgery, Ukraine Transplantation of Endocrine Organs and Tissues of the Ministry of Health of Ukraine

Professor, Ukrainian Scientific and Practical Center for Endocrine Surgery, Transplantation of Endocrine Organs and Tissues of the Ministry of Health of Ukraine

Yuriy M. Stepanov, Institute of Gastroenterology of the National Academy of Medical Sciences of Ukraine

Professor, Institute of Gastroenterology of the National Academy of Medical Sciences of Ukraine

Yury Marakhouski, Department of Gastroenterology and Nutrition Belarus Medical Academy of Postgratuated Education (BelMAPE), Belarus

Head of the Department of Gastroenterology and Nutrition Belarus Medical Academy of Postgratuated Education (BelMAPE)

Olga Zharskaya, Department of Gastroenterology and Nutrition, Belarusian Medical Academy of Post Diploma Studies (BelMAPO), Belarus

Associate Professor, The Department of Gastroenterology and Nutrition, Belarusian Medical Academy of Post Diploma Studies (BelMAPO)

Baurzhan I. Samikovich, Department of Internal Medicine, Kazakh National Medical University (KazNMU), Almaty, Kazakhstan Department of Health of Almaty, Kazakh National Medical University (KazNMU), Almaty, Kazakhstan

Head of the Department of Internal Medicine, Kazakh National Medical University (KazNMU), Almaty & chief gastroenterologist of the Department of Health of Almaty

Negreanu Lucian, Internal Medicine and Gastroenterology – Bucharest Emergency University Hospital, Romania

Associate Professor, Internal Medicine and Gastroenterology – Bucharest Emergency University Hospital, University of Medicine and Pharmacy Carol Davila, Bucharest, Romania

Thein Myint, Department of Gastroenterology, Yangon General Hospital, Myanmar

Head of the department of Gastroenterology, Yangon General Hospital

Amit Garg, Global Medical Affairs, Dr. Reddy’s Laboratories Ltd. Hyderabad, India

Ex -Director - Global Medical Affairs, Dr. Reddy’s Laboratories Ltd. Hyderabad – India

Hardik Pathak, Global Medical Affairs, Dr. Reddy’s Laboratories Ltd. Hyderabad, India

Ex-Lead – Medical Advisor,

Global Medical Affairs, Dr. Reddy’s Laboratories Ltd.

Hyderabad – India

Nadezhda Pavlova, Dr. Reddy’s Laboratories Ltd, Moscow, Russia

Manager – Medico-marketing, Dr. Reddy’s Laboratories Ltd. Moscow - Russia

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