Assessment of clinical efficacy of nefopam hydrochloride in lumbar disc prolapse patients in secondary care hospital
DOI:
https://doi.org/10.18203/2320-6012.ijrms20212513Keywords:
Visual analogue scale, Patient counselling, Patient Document formAbstract
Background: In this study assessing the efficacy of 30 mg of nefopam hydrochloride in lumbar disc prolapse patients.
Methods: This was a prospective observational study. This study was carried out about 6 months in secondary care hospital. 100 patients are involved in this study. Patient documentation forms, visual analogue scale, patient counselling forms are the materials for this study. In this study patients visiting the Hospital with low back pain patients are included in the study. Pregnancy patients and failed back syndrome are excluded in the study.
Results: In this study different age groups of patients as follows 21 patients in 20-30 years of age, 31 patients in 30-40 years of age, 37 patients in 40-60 years of age, 11 patients in 60-80 years of age.
Percentage of pain relief of Nefopam hydrochloride drug therapy as follows, 23 patients in 10-20%, 16 patients in 20-40%, 38 patients in 40-60%, 16 patients in 60-80%, 7 patients in 80-100%. Assessing pain intensity in no. of patients after nefopam hydrochloride drug therapy are as follows 10patients has no pain, 28patients has mild pain, 34patients moderate pain, 15 patients has severe pain, 13 patients are worst pain.
Conclusions: In current study demonstrated that the analgesic efficacies of nefopam hydrochloride in low back pain patients. Nefopam shows better action in mild, moderate, severe and worst pain. Nefopam shows high efficacy.
References
Rosland JH, Hole K. The effect of nefopam and its enantiomers on the uptake of 5-hydroxytryptamine, noradrenaline and dopamine in crude rat brain synaptosomal preparations. J Pharm Pharmacol. 1990;42:437-8.
Mimoz O, Incagnoli P, Josse C. Analgesic efficacy and safety of nefopam vs. propacetamol following hepaticre section. Anaesthesia. 2001;56:520-5.
Rosland JH, Hole K. The effect of nefopam and its enantiomers on the uptake of 5-hydroxytryptamine, noradrenaline and dopamine in crude rat brain synaptosomal preparations. Journal of Pharmacy and Pharmacology 1990.42:437-43.
Gasser JC, Belleville JW. Respiratory effects of nefopam. Clinical Pharmacology & Therapeutics. 1975;18:175-9.
Shirai Y. Low back pain- clinical comprehension and prevention of the high incidence occupational disease. Asian Med J. 1998;41:610-8.
Du Manoir B. Randomized prospective study of the analgesic effect of nefopam after orthopaedic surgery. British Journal of Anaesthesia. 2003;91(6):836-41.
Ok YM, Cheon JH, Nefopam Reduces Dysesthesia after Percutaneous Endoscopic Lumbar Discectomy. Korean J Pain 2016;29:40-7.
Tlgersted T, Comparison Of Nefopam And Pethidine In Postoperative Pain Br J Anaesth. 1976;49:1133.
Evans MS. Nefopam for the prevention of postoperative pain: quantitative systematic review. British Journal of Anaesthesia. 2008;101(5):610-17.
Kakkar M. Single dose oral nefopam for acute postoperative pain in adults. Cochrane Database Syst Rev. 2009;(3):CD007442.
Aymard G, Warot D, Demolis P. Comparative pharmacokinetics and pharmacodynamics of intravenous and oral nefopam in healthy volunteers. Pharmacol Toxicol. 2003;92:279-86.
Lee HG, Kim WM, Kim JM. Intrathecal nefopam-induced antinociception through activation of descending serotonergic projections involving spinal 5-HT7 but not 5-HT3 receptors. Neurosci Lett. 2015;587:120-5.
Dordoni PL, Della Ventura M, Stefanelli A. Effect of ketorolac, ketoprofen and nefopam on platelet function. Anaesthesia 1994;49:1046-49.
Merle JC, Vandroux D, Odin I. Analgesic effect of continuous intravenous nefopam after urological surgery. Ann Fr Anesth Reanim. 2005;24:13-8.
Ottmar K, Lepelletier D. Continuous intravenous nefopam for analgesia in non-lactating women after cesarean section. Anesthesiology. 2007;107:A1781.
Meucci RD. Increase of chronic low back pain prevalence in a medium- sized city of southern Brazil. BMC Musculoskelet Disord. 2013;14:155.
Chanques G, Sebbane M, Constantin JM, Ramillon N, Jung B, Cissé M, et al. Analgesic efficacy and haemodynamic effects of nefopam in critically ill patients. Br J Anaesth 2011; 106: 336-43.
Aluja-Deu JR, Garcia VJA, Carrion JS. Investigación clinica sobre el analgésico no narcótico R-738. Investigación Medica International. 1976;3:37-42.
