Pattern of serum lipid profile of type 2 diabetes patients in a tertiary hospital in Nigeria

Authors

  • Rifkatu S. Reng Department of Medicine, University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria
  • Gerald A. Onwuegbuzie Department of Medicine, University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria
  • Felicia Anumah Department of Medicine, University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria

DOI:

https://doi.org/10.18203/2320-6012.ijrms20212501

Keywords:

Diabetes mellitus, Dyslipidemia, Glycated haemoglobin

Abstract

Background: Diabetes mellitus is a metabolic disorder characterised by chronic hyperglycemia and disturbances of carbohydrate, lipid and protein metabolism. Diabetic patients have an increased risk of developing dyslipidemia with various lipid abnormalities which makes them prone to develop cardiovascular disease. The aim of the study is to determine the patterns of lipid profile in patients with Type 2 diabetes mellitus.

Methods: Lipid profile data for a total of 104 known type 2 DM patients from the medical outpatient clinic were collected. The profile of the study sample was analysed for dyslipidemia using the ATP III classification. Data obtained were analysed using Analyse-it v3.0 statistical software for Microsoft Excel.

Results: This study showed that there were more females 53.8% than males 46.2% with type 2 diabetes mellitus with the mean age of 52.5±11.9 years. The pattern of dyslipidaemia revealed elevated LDL 51.9%, TG 37.5%, TC 36.5% and low HDL 27.9%. We had more patients who were overweight 33.7% than obese 32.7%.

Conclusions: It was observed from the study that a significant number of diabetic patients have dyslipidaemia and most common lipid abnormalities are elevated LDL, triglyceride and low HDL.

References

Bennett HP, Knowler WC. Definition, Classification of Diabetes Mellitus and Glucose Homeostasis. In CR Kahn, GC Weir, GL King, AC Moses, RJ Smith and AM Jacobson editors. Joslin’s Diabetes Mellitus, Philadelphia: LWW. 2000;331.

International Diabetes Federation. IDF Diabetes Atlas 9th Edition. www.diabtesatlas.org. Accessed on 08 April, 2021.

Sultania S, Thakur D, Kulshreshtha M. Study of lipid profile in type 2 diabetes mellitus patients and its correlation with HbA1c. International Journal of Contemporary Medical Research. 2017;4(2):437-9.

Mukhopadhyay J, Kanjilal S, Biswas M. Diabetic dyslipideamia-priorites and targets in India. http://www. apiindia.org/content- mu-2010.html 2013. Accessed on 08 April, 2021.

Taskinen MR. Diabetic dyslipidemia. Atherosclerosis. 2002;3:47-51.

Folli F, Corradi D, Fanti P, Davalli A. The role of oxidative stress in the pathogenesis of type 2 diabetes mellitus micro- and macrovascular complications: avenues for a mechanistic- based therapeutic approach. Curr Diabetes Rev. 2011;7:313-324.

Maritim AC, Sanders RA, Watkins JB. Diabetes, oxidative stress, and antioxidants: A review. J Biochem Mol Toxicol. 2003;17:24-38.

Selvin E, Meta-analysis: Glycosylated hemoglobin and cardiovascular disease in diabetes mellitus. Annals of Internal Medicine. 2004;141:421.

Krauss RM. Lipids and lipoproteins in patients with type 2 diabetes. Diabetes Care. 2004;27(6):1496-504.

Ozder A. Lipid Profile abnormalities seen in T2DM patients in primary healthcare in Turkey: a cross-sectional study. Lipid Health Dis. 2014;13:183.

Bitzur R, Cohen H, kamari Y, Shaish A, Harats D. Triglycerides and HDL Cholesterol: Stars or second leads in diabetes? Diabetes Care. 2009;32(2):273-377.

Okafor CI, Fasanmade OA, Oke DA, Pattern of dyslipidaemia among Nigerians with Type 2 diabetes mellitus. Niger J Clin Pract. 2008;11(1):25-31.

Ogbera AO, Olufanmade OA, Chinenye S, Akindele A. Characterization of lipid parameters in diabetes mellitus-a Nigerian report. Int Arch Med. 2009;2:19.

Sattar N, Gill JMR. Type 2 diabetes as a disease of ectopic fat? BMC Med. 2014;12:123.

Nyasatu G, Shao ER, Sonda T, Lyaruu IA. Lipid profile of Type 2 Diabetic patients at a Tertiary Hospital in Tanzania: Cross Sectional Study. J Endocrinol Diab. 2017;4(1):1-6.

Chapman MJ, Ginsberg HN, Amarenco P. Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for mamagement. Eur Heart J. 2011;32:1345-61.

Stamler J, Vaccaro O, Neaton JD, Wentworth D. Diabetes, other risk factor, and 12 year cardiovascular mortality for men screened in Multiple Risk Factor Intervention Trial. Diabetes Care. 1993;16:434-44.

Goldberg I, J. Diabetic Dyslipidemia: Causes and Consequences. JCEM. 2001;86:965-71.

Li N, Fu J, Koonen DP, Kuivenhoven JA, Snieder H, Hofker MH. Are hypertiglyceridemia and low HDL causal factors in the development of insulin resistance? Atherosclerosis. 2014;233:130-8.

Badimon JJ, Santos-Gallego CG, Badimon L. Importance of HDL cholesterol in atherothrombsis: How did we get here? Where are we going? Rev Esp Cardiol. 210;63:20-35.

Santos-Gallego CG, Ibanez B, Badimon JJ. HDL –cholesterol: Is it really good? Difference between apoA-I and HDL. Biochem. Pharmacol. 2008;76:443-52.

Mooradian Ad. Dyslipidaemia in type 2 diabetes mellitus. Nat Clin Pract Endocr Metab. 2009;5:150-9.

Siraj ES, Seyoum B, Saenz C, Abdulkadir J. Lipid and lipoprotein Profile in Ethopian patients with mellitus. Metabolism. 2006;55(6):706-10.

Al-Habori M, Al-Mmari M, Al-Meeri A. Type 11 diabetes mellitus and impaired glucose tolerance in Yemen: frequency, associated metabolic changes and risk factors. Diabetes Res Clin Pract. 2004;65:275-81.

Mrgan M, Funck KL, Gaur S, Ovrehus KA, Dey D, Kusk MW. High burden of coronary atherosclerosis in patients with a new diagnosis of type 2 diabetes. Diabetes Vasc Dis Res. 2017;14:468-76.

Wu L, Parhofer KG. Diabetic dyslipidemia. Metabolism. 2014;63:1469-79.

Rema M, Srivastava BK, Anitha B, Deepa R, Mohan V. Association of serum lipids with diabetic retinopathy in urban South Indians—The Chennai Urban Rural Epidemiology Study (CURES) Eye Study-2. Diabetes Med. 2006;23:1029-36.

Rutledge JC, Ng KF, Aung HH, Wilson DW. Role of triglyceride-rich lipoproteins in diabetic nephropathy. Nat. Rev. Nephrol. 2010;6:361-70.

Al-Ani FS, Al-Nimer MS, Ali FS. Dyslipidemia as a contributory factor in etiopathogenesis of diabetic neuropathy. Indian J Endocrinol Metab. 2011;15:110-4.

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Published

2021-06-25

How to Cite

Reng, R. S., Onwuegbuzie, G. A., & Anumah, F. (2021). Pattern of serum lipid profile of type 2 diabetes patients in a tertiary hospital in Nigeria. International Journal of Research in Medical Sciences, 9(7), 1854–1858. https://doi.org/10.18203/2320-6012.ijrms20212501

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Original Research Articles