Effect of Syzygium cumini (jamun) seed powder on dyslipidemia: a double blind randomized control trial

Shivani Sidana; Veer Bahadur Singh; Babu Lal Meena; Sanjay Beniwal; Subhash Chandra; Kulvinder Singh; Rahul Singla; Deepak Kumar

doi:10.18203/2320-6012.ijrms20161917

Authors

Shivani Sidana Department of Medicine, S.P.M.C., Bikaner, Rajasthan
Veer Bahadur Singh Department of Medicine, S.P.M.C., Bikaner, Rajasthan
Babu Lal Meena Department of Medicine, S.P.M.C., Bikaner, Rajasthan
Sanjay Beniwal Department of Medicine, S.P.M.C., Bikaner, Rajasthan
Subhash Chandra Department of Medicine, S.P.M.C., Bikaner, Rajasthan
Kulvinder Singh Department of Medicine, S.P.M.C., Bikaner, Rajasthan
Rahul Singla Department of Medicine, S.P.M.C., Bikaner, Rajasthan
Deepak Kumar Department of Medicine, S.P.M.C., Bikaner, Rajasthan

DOI:

https://doi.org/10.18203/2320-6012.ijrms20161917

Keywords:

Syzygium cumini, Dyslipidemia, Diabetes mellitus, Seed powder

Abstract

Background: Diabetes is a metabolic syndrome characterized by disturbance in carbohydrate, fat and protein metabolism. Dyslipidemia, commonly associated in diabetes, is major risk factor for macrovascular complications leading to CAD, major contributor to mortality associated with diabetes. Managing DM without side effects is challenge that attracts researchers toward plant based new products. Many studies have found anti-diabetic and anti-hyperlipidemic properties of seeds of Syzygium cumini, attributed to saponins, glycosides and flavonoids. So it should be further explored for its benefits. The aim was to study the effect of jamun seed powder on dyslipidemia in type 2 DM.

Methods: Patients with type 2 DM were randomly divided in two groups- group A was supplemented with 10 gms/day jamun seed powder and group B was given placebo powder. Patients and investigators were blinded about treatment allocated. Lipid profile was noted at baseline and 30^th, 60^th and 90^th day. All the data was collected and analyzed at the end of study.

Results: Improvement in dyslipidemia was seen after 60 days of supplementation with S. cumini seed powder. Statistically significant decrease in cholesterol levels by 10.55% and 15.79% in mean triglyceride levels by 8.28% and 13.66%, LDL-c levels by 10.29% and 14.50% was noticed at 60^th and 90^th day, respectively, reduction in VLDL-c levels by 9.38%, 12.90% and 20.69% was noted at 30^th, 60^th and 90^th day. HDL-c increased significantly by 11.11% and 13.89% in males and 10.81% and 16.21% in females after 60 and 90 days of supplementation with S. cumini seed powder.

Conclusions: A significant overall effect of S. cumini supplementation was found in improvement of lipid profile in type 2 diabetes subjects. However, above results are seen in small number subjects, further multicenter studies with larger sample size, supplementation dose and time should be planned and its effects in detail should be explored.

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