Study of inspiratory lung function parameters in Indian children

Sudeep H. Kale, Mangala Deshpande, Pandurang V. Thatkar, Sandip S. Chaudhari, Manisha S. Deshpande


Background: The inspiratory parameters of pulmonary function test commonly used for various purposes in clinical practice including diagnosing airway obstruction. Expiratory portion of the flow volume loop of the pulmonary function test is studied in detail. The prediction equations for expiratory parameters are available for different population. However, the reference equation for inspiratory parameters is not available in Indian context. The current study derived the prediction equation for inspiratory parameters of pulmonary function test.

Methods: The current study was carried out in school going 732 healthy girls and 1377 boys aged 6-15 years in India.  The children who meet the inclusion criteria were recruited in the study after detailed medical examination by registered medical practitioner. The lung function parameters were recorded by spirometry. The multivariate regression analysis was done to develop the prediction model.

Results: The prediction equation for predicting inspiratory parameter were developed. This study revealed gender-wise and geographical variation in the inspiratory parameters. Hence this study recommends to derive gender wise prediction equations. The reference equations derived in this study can be used in population with similar background.

Conclusions: Use of these equations for population having similar backgrounds will help for early and accurate diagnosis of the airway abnormalities in children. The inspiratory parameter assessment shall be included in the routine assessment of respiratory patient.


Peak inspiratory flow rate, Pulmonary function, Inspiratory volume, Prediction equation, Flow volume loop

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