Published: 2021-06-25

Clinical and radiological profile of patients with cerebral venous and sinus thrombosis in a tertiary care hospital

Sudha Vidyasagar, Aasish Peddu, Nandakrishna Bolanthakodi, Cynthia Amrutha


Background: Cerebral venous and sinus thrombosis (CVT) is one of the common causes of stroke in young people. It is a relatively uncommon neurologic disorder that is potentially reversible with prompt diagnosis and appropriate medical care. The purpose of this study is to identify the clinical and radiological features aiding diagnosis of cortical vein thrombosis

Methods: A cross-sectional study was conducted from November 2015 to May 2017 in tertiary care centre in Manipal after institutional ethical clearance. A total of 46 patients diagnosed with CVT were included in the study. Clinical symptoms and signs at admission and radiological features were documented.

Results: A total of 46 subjects were included. Males (53.3%) were more affected than females (46.7%), mostly in the 3rd decade. The most common risk factors were polycythaemia (31.1%) and oral contraceptive pill intake (17.7%). Headache was the most common symptom followed by paralysis and seizures. Multiple sinuses were involved in two-thirds of the patients. Superior sagital sinus thrombosis was the most common sinus involved followed by transverse sinus thrombosis

Conclusions: The most common clinical feature is headache followed by paresis and seizures. Superior saggital sinus thrombosis is more common than transverse and sigmoid sinus thrombosis in Indian population. Normal CT scan of brain doesn’t rule out cerebral venous sinus thrombosis.


Cerebral venous sinus thrombosis, Stroke, CVT

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Ferro JM, Canhao P, Stam J. Prognosis of cerebral vein and dural sinus thrombosis: results of the International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT). Stroke. 2004;35:664.

Dash D, Prasad K, Joseph L. Cerebral venous thrombosis: An Indian perspective. Neurol India. 2015;63:318-28.

Ferro JM, Lopes MG, Rosas MJ, Ferro MA, Fontes J. Cerebral venous Thrombosis-Portuguese collaborative study group (VENOPORT): long-term prognosis of cerebral vein and dural sinus thrombosis: results of the VENOPORT study. Cerebrovasc Dis. 2002;13:272-8.

de Bruijn SFTM, de Haan RJ, J Stam. Clinical features and prognostic factors of cerebral venous sinus thrombosis in a prospective series of 59 patients. J Neurol Neurosurg Psychiatry. 2001;70:105-8.

Hameed B, Syed NA. Prognostic indicators in cerebral venous sinus thrombosis. J Pak Med Assoc. 2006;56(11):551-4.

Arber DA, Orazi A, Hasserjian R. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood. 2016;127:2391.

Bobba RS, Johnson SR, Davis AM. A review of the sapporo and revised Sapporo criteria for the classification of antiphospholipid syndrome. Where do the revised sapporo criteria add value? J Rheumatol. 2007;34:1522.

Ueland PM, Refsum H, Stabler SP, Malinow R, Andersson A, Allen RH. Total homocysteine in plasma or serum: Methods and clinical applications. Clin Chem. 1993;39:1764-79.

Pai N, Ghosh K, Shetty S. Hereditary thrombophilia in cerebral venous thrombosis: A study from India. Blood Coagul Fibrinolysis. 2013;24:540 3.

Narayan D, Kaul S, Ravishankar K, Suryaprabha T, Bandaru VC, Mridula KR, et al. Risk factors, clinical profile, and long term outcome of 428 patients of cerebral sinus venous thrombosis: Insights from Nizam’s Institute Venous Stroke Registry, Hyderabad (India). Neurol India. 2012;60:154 9.

Wassay M, Bakshi R, Bobustuc G, Kojan S, Sheikh Z, Dai A, et al. Cerebral venous thrombosis: Analysis of a multicenter cohort from the United States. J Stroke Cerebrovasc Dis. 2008;17:49 54.

Patil VC, Choraria K, Desai N, Agrawal S. Clinical profile and outcome of cerebral venous sinus thrombosis at tertiary care center. J Neurosci Rural Pract. 2014;5:218-24.

Naveen T, Krishna GR, Vengamma B, Dayakar D, Dushyanth J. Clinical Manifestations, Radiological Findings and Outcome in Cerebral Vein and Dural Sinus Thrombosis: A Prospective Study. J Evid based Med Healthc. 2015;2(39):6171-81.

Walecki J, Mruk B, Nawrocka-Laskus E. Neuroimaging of Cerebral Venous Thrombosis (CVT) Old Dilemma and the New Diagnostic Methods. Polish Journal of Radiology. 2015;80:368.

Alet M, Ciardi C, Alemán A, Bandeo L, Bonardo P, Cea C, Cirio J. Argentinian Stroke and Cerebrovascular Diseases Study Group - Argentine Neurological Society. Cerebral venous thrombosis in Argentina: clinical presentation, predisposing factors, outcomes and literature review. J Stroke Cerebrovasc Dis. 2020;29(10):105145.

Dhadke VN, Dhadke SV, Kulkarni A. Clinical Profile of Cerebral Venous Sinus Thrombosis. J Assoc Physicians India. 2020;68(3):33-5.